Báo cáo y học: "Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis" doc
Báo cáo y học: "Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis" doc
... work is properly cited.
Histone deacetylase inhibition in stem cell differentiation<p>A gene profiling study of mouse embryonic stem cells treated with the histone deacetylase inhibitor ... inhibitor trichostatin A shows that inhibition of histone deacetylases accelerates the early events of differentiation, by regulating the expression of pluripotency-...
Báo cáo y học: "Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice" docx
... Kumagai
1,2
Abstract
Introduction: The purpose of this study was to elucidate the effects of histone deacetylase inhibition on the
phenotype and function of dendritic cells and on arthritis in SKG mice.
Methods: ... proliferation
in the synovium, leading to the progressive destruction
of the jo ints. Dendritic cells, monocytes, T cells, B cells,
and neutrophils i...
Báo cáo y học: "Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock" potx
... their results
to other populations of critically ill patients. The number
of patients was also limited and analyses concerned only
the steady-state of the disease. Finally, some of these
studies ... renal failure
requiring dialysis; or allergy to any of the investigated
antibiotics. The study period was limited to the first 24
hours of antibiotherapy.
Administration...
Báo cáo y học: "Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption" ppt
... family of 23
enzymes in man that facilitate turnover and breakdown of the
ECM in both physiology and pathology. The MMP family con-
tains the only mammalian proteinases that can specifically
degrade ... collagenolytic enzymes in
explant-conditioned culture medium and also the activation of
these enzymes. In cell culture, these effects are explained by the
ability of...
Báo cáo y học: " Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils" docx
... analysis of 3-(4-benzoyl-1-
methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic
histone deacetylase inhibitor inducing histone hyperacetylation, growth
inhibition, and terminal cell ... warranted.
HDACinhibitorsareuniqueinthesensethatthey
antagonize cytoki ne-afforde d survival of eosinophils and
neutrophils despite the vast amount of literature that
indicates that...
Báo cáo y học: "Histone deacetylase inhibitor, butyrate, attenuates lipopolysaccharide-induced acute lung injury in mice" pptx
... suggested
that the anti-inflammatory effects of butyrate in ALI
may primarily rely on inhibition of IB degradation, and
consequently inhibiting the nuclear translocation of NF-
B and the production of cytokines ... (MIP-1a), they
have earned a position of prominence at the head of the
inflammatory cytokine cascade [27]. Therefore, the inhi-
bition of TNF-a a...
Báo cáo y học: " Histone deacetylases — a new target for suppression of cartilage degradation" pdf
... project beyond the
surrounding DNA. In the case of H3 and H4, specific lysine
sidechains undergo acetylation, through the action of histone
acetyltransferases, by way of acetyl coenzyme A, a step
which ... degradation of aggrecan
and collagen. The histone deacetylase inhibitors trichostatin A and
butyrate were shown to drastically reduce expression of these
enzymes r...
Báo cáo y học: "Src kinase inhibition promotes the chondrocyte phenotype" ppsx
... are
involved in glycosaminoglycan synthesis. Transcripts for the
xylosyltransferases were significantly increased at days 1 and
2 (Xylt1) or days 2 and 3(Xylt2) in response to Src family inhi-
bition ... proteoglycans such as aggrecan by
xylosyltransferases 1 and 2 (encoded by the Xylt1 and Xylt2
genes, respectively) [8-10]. Glycosaminoglycans require sul-
phation for function, a...
Báo cáo y học: "Histone tales: echoes from the past, prospects for the future" ppt
...
Although these chromatin marks seem to be central to
the formation of a kind of rudimentary memory, they do
not suffice to control the overall transcriptome. However,
Figure 1. The life cycle of C. ... eukaryotes and could underpin
processes in cellular memory of profound socioeconomic
and medical implications [7,8]. In any case, the availa-
bility of powerful tools su...
Báo cáo y học: "BACE-1 inhibition prevents the g-secretase inhibitor evoked Ab rise in human neuroblastoma SH-SY5Y cells" ppsx
... responsible for the synthesis
of the inhibitors used in the study. ME designed the plasmids used for
transfection of the cells. EL organized the study, participated in the study
design and revised the manuscript. ... APPswe-transfected SH-SY 5Y
cells. The three bands detected with 6E10 antibody in the cell lysates are most likely isoforms of full-length APP or m...