Báo cáo y học: " Genetic determinants of phenotypic diversity in humans" pot

... p53 may play more important role in esophageal cancer risk. In the present meta-analysis on the association between p53 Arg72Pro, GSTP1 Ile105Val polymor- phisms and risk of esophageal cancer, ... Prior to this, SCC comprised more than 95% of esophageal malignancies [48]. In our meta-analysis, we had wanted to analysis the associa- tion between these two gene polymo...

Ngày tải lên: 25/10/2012, 11:40

... alignment of the interdomain and autolysis loops of mammalian chymotrypsins and trypsins. The enzyme that was used in this study, rat chymotrypsin B, is highlighted by bold type. The loops are boxed and ... 2). Finally it is of interest regarding the in vivo mechanism of inactivation, that chymotrypsin and trypsin, mixed in concentration ratios close to thos...

Ngày tải lên: 22/02/2014, 07:20

... the pathogenesis of a variety of autoimmune diseases, including Sjögren’s syndrome. Numerous investigators have attempted to analyze the association of primary Sjögren’s syndrome with cytokine polymorphisms, ... HLA Review Genetic aspects of Sjögren’s syndrome Anne Isine Bolstad 1,2 and Roland Jonsson 1 1 Broegelmann Research Laboratory, Department of Microbiology and Immuno...

Ngày tải lên: 09/08/2014, 01:21

... recombinant inbred strains with over- Editorial Genetic control of disease in an experimental model for Sjögren’s syndrome Åsa Andersson Department of Pharmacology and Pharmacotherapy, Faculty of ... exocrino- pathy in the NOD mouse and by reducing one of these regions considerably, Nguyen et al. in a recent issue of Arthritis Research and Therapy propose can...

Ngày tải lên: 09/08/2014, 01:22

... and investigation of pathways that lead to disease, well into the future. Introduction The history of genome-wide mapping of disease-causing genes began in 1980, when linkage analysis by use of ... complex diseases. In light of this success, we must consider how best to use animal models in the future; is there still value in identifying the genes that affect s...

Ngày tải lên: 09/08/2014, 01:22

... men and women in the change in lateral tibial plateau bone area. Table 2 Annual change and rate in tibial plateau bone area Crude analysis Adjusted analysis Annual change Total P Men Women P a Men ... Principal outcome meas- ures in analyses were annual change and annual percentage change of tibial plateau bone area. Change in this area was o...

Ngày tải lên: 09/08/2014, 06:22

... functionally distinct with regards to production of cytokines and extracellular matrix [16,17] and it was recently demonstrated that only Thy-1 +ve fibroblasts are capable of differentiating into myofibroblasts after ... of myofibroblasts in dcSSc skinDetection of myofibroblasts in dcSSc skin. Cryosections from (a) nor- mal and (b-f) dcSSc skin were stained with an antib...

Ngày tải lên: 09/08/2014, 07:20

... knee osteoarthritis and age- and sex-matched controls with no family history of knee osteoarthritis, a population-based longitudinal study of 163 matched pairs (mean age 45 years, range 26 to 61) was ... graded as described previously [11] on two occasions of MRI sagittal scans at medial tibial, lateral tibial and patellar sites as follows: grade 0, normal cartilage; grade 1,...

Ngày tải lên: 09/08/2014, 07:20

... Family study of affective spectrum disorder. Arch Gene Psychiatry 2003, 60: 170-177. 30. Walsh CM, Zainal NZ, Middleton SJ, Paykele ES: A family history study of chronic fatigue syndrome. Psychiatr ... aggregated strongly in families: the odds ratio measuring the odds of fibromyalgia in a relative of a proband with fibromyalgia versus the odds of fibromyalgia in a relative of...

Ngày tải lên: 09/08/2014, 08:22

... recombinant inbred strains with over- Editorial Genetic control of disease in an experimental model for Sjögren’s syndrome Åsa Andersson Department of Pharmacology and Pharmacotherapy, Faculty of ... exocrino- pathy in the NOD mouse and by reducing one of these regions considerably, Nguyen et al. in a recent issue of Arthritis Research and Therapy propose candida...

Ngày tải lên: 09/08/2014, 13:22

... cells to undergo a Th1 to T-helper type 2 shift and increase the secretion of anti-inflammatory cytokines IL-10 and IL-4, while decreasing the secretion of proinflammatory cytokines TNFα and IL-1 ... most of the available information regarding the temporal cytokine profiles in arthritic LEW rats pertained to antigen nonspecific ex vivo cytokine secretion or to cytokine mRNA le...

Ngày tải lên: 09/08/2014, 14:22

... of < /b> HIV-1 < /b> Circulating < /b> Recombinant < /b> Form < /b> 02_AG, < /b> B and C subtype-specific envelope sequences from Northern India and their predicted co-receptor usage Ujjwal Neogi 1 , Vikas Sood 1 , Arpita Chowdhury 1 , ... purposes) Phylogenetic analysis < /b> of < /b> the HIV-1 < /b> envelope sequences from North IndiaFigure 2 Phyloge...

Ngày tải lên: 10/08/2014, 05:21

... The ACE presented in the serum catalyzes the hydrolysis of the FAGG; forming furyl acryloyl phenylalanine (FAP). The decrease of the absorbance in the unit time at 340 nm is proportional to the ... Genetic polymorphism of ACE and the angiotensin II type1 receptor genes in children with chronic kidne y disease. Journal of Inflammation 2...

Ngày tải lên: 11/08/2014, 03:20

... Elshamaa et al.: Genetic polymorphism of ACE and the angiotensin II type1 receptor genes in children with chronic kidne y disease. Journal of Inflammation 2011 8:20. Submit your next manuscript ... either through reducing the production of angiotensin II with ACEI or by blocking the action of angiotensin II at the AT1R receptor level wi...

Ngày tải lên: 11/08/2014, 06:23

... [4-6]. The study of inheritance of genetic variation depends on two key concepts: genetic linkage and linkage disequilibrium (Figure 2). Two loci are in genetic linkage if they are physi- cally close ... Science in 2007, reflecting the marked advances in understanding the genetic basis of normal human phenotypic diversity and susceptibility to a wide range of disease...

Ngày tải lên: 14/08/2014, 08:21