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Báo cáo y học: " Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients" ppsx

Báo cáo y học:

Báo cáo y học: " Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients" ppsx

... Access Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patientsCaroline Guignant1, Alain Lepape2, Xin Huang3, Hakim ... not only may play a role in immune dysfunction but also may be an indicator of septic mor-tality and subsequent infectious episodes in septic patients. Increased expressions of co-inhibitory as ... anti-inflammatory cytokines(mainly interleukin-10 (IL-10) and transforming growthfactor-beta) [7], increased lymphocyte apoptosis [8], increased proportion of circulating regulatory T cells* Correspondence:...
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Báo cáo y học: "Different effect of exercise on left ventricular diastolic time and interventricular dyssynchrony in heart failure patients with and without left bundle branch block"

... mechanical dyssynchrony during pacing–induced tachycardia in patients with normal QRS duration (21). A remarkable increase in intra-LV dyssynchrony was also demonstrated during pharmacological ... of LV systolic duration is increased in pa-tients with dilated cardiomyopathy. A disturbed elec-tromechanical activation leading to intraventricular dyssynchrony is typically present in patients ... during stress (22). Further-more, exercise LV dyssynchrony may play a more important role in the pathophysiology of left ven-tricular remodelling than baseline LV dyssynchrony (23). Probably...
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Báo cáo y học:

Báo cáo y học: "Analysis of N-terminal pro-B-type natriuretic peptide and cardiac index in multiple injured patients: a prospective cohort study" docx

... kin or a legal representative. Patients dying within 24hours after the incident or with initial myocardial injury wereexcluded. Patients with traumatic brain injury, identified bysigns of intracranial ... study is that patients with increased clinical signs of organ dysfunction following multipleinjury had significantly increased NT-proBNP levels of greaterthan 200 pg/mL on admission, increasing ... function in multipleinjured patients by analyzing NT-proBNP serum levels along with an invasive hemodynamic monitoring and to correlate theresults to clinical signs of MODS.Materials and methodsStudy...
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báo cáo hóa học: " Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer''''s disease" potx

... on asmall number of cytokines within the same sample. It isnot clear which cytokines are key in promoting and main-taining the inflammatory environment in the AD brain.Furthermore, it is ... sub-units; IL-12p40 and IL-12p35. It is produced mainly bymonocytes and macrophages and is a crucial factor in directing the T-cell response to infection, by inducing aTh1-type cytokine response. ... established and multiple cytokine levels were analyzed using the Bio-plexmultiple cytokine assay system. Soluble and insoluble forms of Aβ were quantified and Aβ-cytokinerelationships were analyzed.Results:...
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Báo cáo y học: " Myeloid dendritic cells correlate with clinical response whereas plasmacytoid dendritic cells impact autoantibody development in rheumatoid arthritis patients treated with infliximab" pdf

... patients with active disease were characterized bya baseline decrease in both circulating pDCs and mDCs.Disease activity markers inversely correlated only with mDClevel. This level increased in ... longitudinalfollow-up in patients receiving infliximab.Methods Circulating mDC and pDC levels were evaluated byflow cytometry in RA patients (n = 61) and healthy volunteers (n= 30). In RA patients, these levels ... to infliximabtherapy, to reach the level observed in controls. Conversely, anti-nuclear antibody appearance during infliximab therapycorrelated inversely with pDC level and was associated with increased...
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Báo cáo y học:

Báo cáo y học: "A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes"

... 8underlying physiology, there is a combination of physio-logical factors predisposing a patient for hyperglycaemia in acute illness, during which hyperglycaemic mecha-nisms in stress and inflammatory ... tohyperglycaemia are a subject of speculation, but almostcertainly include pre-existing increased insulin resistance and dysfunction of beta cells. Insulin resistance is present in the acutely ... [13,15,18,28] in different intensity, butthe factors determining the extent of insulin resistanceare not known. Our observation that body mass index,which is certainly associated with insulin resistance...
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Báo cáo y học:

Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"

... activity of nitric oxide synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in ... findings of NO involvement in pathophysiol-ogy of hypobaric hypoxia in brain (42-43). In this study the increased activity of NOS in anoxia may represent predominantly the nNOS form. In inflam-matory ... nNOS and increased activity may be mainly by iNOS due to expected inflammation after anoxia. The Figure 2 shows activities of AS, AL and arginase in the study. AS and AL activities increased in...
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Báo cáo y học: "Assessment of epicutaneous testing of a monovalent Influenza A (H1N1) 2009 vaccine in egg allergic patients" potx

... ntent of the vaccine. Influenza vaccines aredeveloped by inoculating embryonated chicken eggs with virus and thus contain ovalbumin. A recent reviewof ovalbumin content in H1N1 vaccines found a ... negativeskin prick test and challenge are highly predictive ofsafely tolerating vaccine administration. In the past, influ-enza vaccines have been contraindicated in patients with egg allergy due ... thatalmost all skin tests to the H1N1 vaccine were negativemaking the role of skin testing questionable. Administer-ing the vaccine in a 1 or 2 dose protocol without skin test-ing is a reasonable...
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Báo cáo y học: "Intra-articular injection of recombinant TRAIL induces synovial apoptosis and reduces inflammation in a rabbit knee model of arthri" pdf

... corresponding to the microscopic findings in hematoxylin and eosin staining. In addition, leukocyte infiltrationinto the synovial fluid of the inflamed knee joints following rTRAILtreatment was reduced ... degree of TUNEL staining in synovial tissue sections. Investigators blindly reviewed primarily two areas: synovial lining and subsynovial regions. The extent of staining in these areas was ... into the inflamed joints, indicating that TRAILmay inhibit joint inflammation. The mechanism through whichTRAIL functions to reduce leukocytosis in inflamed joints isunclear. Interestingly,...
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Báo cáo y học: "Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection" ppt

... such as cyclosporin-A, and Th2-type cytokines including interleukin-4 and -10 coun-teract the production of neopterin [21]. The same is truefor anti-inflammatory compounds including certainHMG-CoA ... compartmental-ized HIV infection within CNS macrophages [46],whereas infection in the non-ADC patients may belargely transitory, non-compartmentalized and supportedwithin lymphocytes with less robust ... considering what these findingsindicate and how neopterin might be used in the future.While CSF neopterin has been known to be elevated in HIV infection and further increased in ADC/HIVE and CNS...
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