Báo cáo y học: " Indirect genomic effects on survival from gene expression data" doc

... detection, separation, quantification and comparison of possible direct and indirect effects on survival that are mediated by transcription factors. We consider a data set with genes, the expression ... the targeted therapy. Conclusion Dynamic path analysis of large scale gene expression data provides reliable quantification of indirect effects of transcription factors on...

Ngày tải lên: 14/08/2014, 08:20

... NFκB also contained genes either not previously associated with or only tentatively associated with NFκB activity in subsets of B-cell lymphomas. The gene- expression profiles from this consensus ... membership derived from external validation with gene function annotations, it was possible to accurately and rapidly identify specific transcriptionally co-regulated genes from microa...

Ngày tải lên: 14/08/2014, 14:21

... by the systemic inflammatory response syndrome and then by the compensatory anti-inflammatory response syndrome, which is defined by low human leukocyte antigen (HLA)-DR expression on monocytes, ... patients: Key messages • Increased TREM-1 expression on blood monocytes is an indicator of inflammation but not of infection in patients with AP. • Low HLA-DR expression and high IL-6...

Ngày tải lên: 13/08/2014, 16:20

... analysis not only to the ratio of evolutionary rates, but also to individual synonymous and non-synonymous evolutionary rates. More- over, we carefully screened rearranged and colinear regions together ... coding regions would rule out this explanation, as coding sequences are, on average, under stronger functional constraints than non-coding regions. But why should non-synonymous and non-c...

Ngày tải lên: 14/08/2014, 08:20

... and Sjögren’s syndrome In contrast to the focal sialadenitis of the minor (labial) sali- vary glands, the lymphocytic lesions of the major salivary glands often contain secondary lymph follicles. ... autoimmune inflammatory disorder. Keywords: autoimmunity, B cells, IgV gene usage, lymphocytes, Sjögren’s syndrome Review Abnormalities of B cell phenotype, immunoglobulin gene expression a...

Ngày tải lên: 09/08/2014, 01:21

... study reactivation of those few– if any–latent proviruses. We conclude that stimulation of viral integration by the INS and INrs peptides, combined with the preven- tion of virion production by ... pro- duction (Fig. 1a) and in viral cDNA integration (Fig. 1d II ) was observed only during the first 2-4 days PI. On the other hand a drastic reduction in both virus produc- tion and cDNA integr...

Ngày tải lên: 10/08/2014, 05:21

... hemophagocytic lymphohistiocytosis and severe sepsis/systemic inflammatory response syndrome/multiorgan dysfunction syndrome/macrophage activation syndrome share common intermediate phenotypes on a ... upregulation of an erythropoiesis gene- expression signature occurred predominantly in individuals with sJIA and anemia. Strikingly, a discrepancy was noted with strong erythro- poiesis-re...

Ngày tải lên: 12/08/2014, 14:22

... after ROSC. Post- resuscitation myocardial dysfunction is now recognised as a separate entity from myocardial stunning secondary to coronary artery occlusion and may lead to a worse prognosis [54]. ... disability. Conscious. Moderate cerebral disability alone (CPC 2) or moderate disability from non-cerebral system dysfunction alone or both. Performs independent activities of daily life....

Ngày tải lên: 13/08/2014, 08:20

... identified alterations in gene expression profiles unique to cell cycle regulation, apoptosis, and T lymphocyte signaling/activa- tion. Although p30 II expression, as might be expected from earlier reports, ... and ultimately repressing viral gene expression. This interac- tion may be directly linked to splicing factors and splicing and/or the juxtaposition of specific exon/exon j...

Ngày tải lên: 13/08/2014, 13:20

... human genome. His results confirm that trimethylation on H3 K4 correlates with transcription initiation, whereas trimethylation on H3 K27 correlates with transcript elongation. He also identified multiple ... regulating gene expression, as well as the extent of post-transcriptional regulation. Epigenetic modifications, the dynamic nature of chromatin and its role in regulating gene...

Ngày tải lên: 14/08/2014, 07:21