... Coordinated inhibition of squalene synthetase and induction of enzymes of sesquiterpe-noid phytoalexin biosynthesis in cultures of Nicotiana tabacum.Phytochemistry 27, 2567–2580.18.Mercke,P.,Crock,J.,Croteau,R.&Brodelius,P.E.(1999)Cloning, ... activity of squalene synthase (SS), an enzymecatalysing the formation of squalene from two molecules of FPP, is observed. Obviously, a shift in flow of metabolites,i.e. FPP, is achieved by these ... diphosphate/dimethylallyldiphosphate by farnesyl diphosphate synthase (FPPS).Thus, fusion of the two enzymes, FPPS and eAS, wouldgive a bifunctional enzyme that catalyses the conversion of the C5-substrate isopentenyl diphosphate...