Báo cáo y học: "Computational identification of obligatorily autocatalytic replicators embedded in metabolic networks" docx

... 9:R51 Autocatalytic synthesis of coenzymes in Synechocystis spFigure 2 Autocatalytic synthesis of coenzymes in Synechocystis sp. (a) Coenzyme A. (b) NAD + . (c) Tetrahydrofolate. Autocatalytic ... autocatalysts since they are intermediates of the same autocatalytic cycle [11]. However, analysis of autocatalytic coenzyme synthesis in general is a challenge. Following th...

Ngày tải lên: 14/08/2014, 08:20

... specificity and selectivity of CRM searches based on binding-site clusteringFigure 5 Inclusion of evolutionary information greatly increases the specificity and selectivity of CRM searches based on binding-site ... single-species binding-site cluster search, a number of interesting pdm2 regions were discovered in our eCIS-ANA- LYST search (two are listed in Table 4). Inclusion o...

Ngày tải lên: 14/08/2014, 14:21

... binding in plant coding regions. We next examined microRNA binding in animal coding regions. While animal untranslated regions have been studied extensively for microRNA binding, animal coding ... the past few years, coding nucleotide sequences have been shown to contain a myriad of functions independent of their encoded protein sequences [1]. Synonymous sites (sites in coding seque...

Ngày tải lên: 09/08/2014, 20:21

... Blocking it severely restrained and often eliminated for- mation of INTRALUMINAL CELL CLUSTERS. Dynamic phenotype Figure 9 presents dynamic phenotype: the normalized fre- quency of axiom use by ... tightly must ISEA adhere to its operating principles before aspects of phenotype become measurably abnormal? We gained insight into plausible answers by systematically relaxing two, key ISEA...

Ngày tải lên: 13/08/2014, 16:21

... a patient who likely has a lymphocytic variant of hypereosinophilic syndrome that resulted in eosinophilic infiltration of the gastroin- testinal tract, sinuses, and airway that contributed to variable ... identify eosinophilic inflammation. Introduction Eosinophilic gastrointestinal disease (EGID) is character- ized by identification of abnormal eosinophilic infiltra- tion on morph...

Ngày tải lên: 08/08/2014, 21:20

... production of miRNAs in the RNA interference pathway. Interestingly, heterochro- matin protein 1, or HP1 is a member of the chromatin remodeling family of proteins, which can bind histones at methylated ... tumor-suppressor pathway which acts to arrest the cell-cycle at G1/S by inhibiting the binding of cdk4/6 to Cyclin D1 and subse- quently inhibiting the phosphorylation of Rb....

Ngày tải lên: 10/08/2014, 05:21

... cystadenocarcinoma mimicking advanced colorectal cancer in a 68 yr-old African American female. Radiology, endoscopy and cytology yielded only inconclusive findings. Immunohistochemical analysis of percutaneously obtained ... for accurately diagnosing patients with inconclusive findings in the setting of peritoneal carcinomatosis and primary peritoneal cystadenocarcinoma. Introduction...

Ngày tải lên: 11/08/2014, 10:23

... an 88% risk of infection. Introduction Nosocomial infections are an increasingly common cause of morbidity and mortality [1], particularly among critically ill patients [2,3]. In intensive care ... is characterized by a number of signs such as fever, tachycardia, tachypnea and leukocytosis [4,5]. These signs are very sensi- tive but are poorly specific of infection, can occur in a...

Ngày tải lên: 12/08/2014, 23:23

... profilins [26] bind to and modulate actin microfilament assembly, and also bind phosphati- dylinositol-4,5-bisphosphate and poly-proline, thus being important in signalling pathways. Profilins ... determination of protein concentration; typically the extracts contained ~1 mg protein/ml. Determination of the protein concentration Protein concentration was determined according to Brad- fo...

Ngày tải lên: 13/08/2014, 13:22

... DMSO: Dimethyl sulfoxide; EDTA: Ethylenediaminetetraacetic acid; NCBI: National Center for Biotechnology Information; PCR: polymerase chain reaction; PRK: phosphoribulokinase; PVP: polyvinylpolypyrrolidone. Acknowledgements The ... products in the amplification of PRK gene. Lodoicea maldivica yielded only one single PCR product in the analysis of PRK gene. The sample should be conside...

Ngày tải lên: 13/08/2014, 14:20