Báo cáo y học: "Cross-kingdom patterns of alternative splicing and splice recognition" docx

... employed and the frequencies of splicing vary among organisms. Bacteria and archaea lack the spliceosomal pathway and splice infrequently via self -splicing introns. Among unicellular eukaryotes, ... demonstrated experimentally in the yeasts Saccharomyces and Schizosac- charomyces [17,27], and in plants [42]. Our analysis extends this result to all ascomycetes, as well as bas...

Ngày tải lên: 14/08/2014, 08:20

... mRNA isoforms induced by insulin and winglessFigure 2 Numerous changes in alternatively spliced mRNA isoforms induced by insulin and wingless. (a) Features of microarray design. The array contains ... global impact of signaling cascades on alternative splicing (reviewed in [24- 26]). Only a handful of examples of signal-induced alternative splicing have been identified an...

Ngày tải lên: 14/08/2014, 21:20

... classical and alternative pathways of NF-κB activation regulate survival and activation of T and B lymphocytes at their sites of development in thymus, bone marrow and spleen, and in the periphery. ... many inflammatory conditions may be partly or largely driven by Th17 and not by Th1, as was erroneously concluded previously [88,93-96]. Th17 and/ or IL-17 have been report...

Ngày tải lên: 09/08/2014, 10:23

... (2,218 and 2,598 genes, respectively). Lists of spliced/un spliced genes were then ranked in descending order and split into 10 equal groups (approximately 220 and 260 genes per group for spliced and ... Differential patterns of intronic and exonic DNA regions with respect to RNA polymerase II occupancy, nucleosome density and H3K36me3 marking in fission yeast. Genome Biolog...

Ngày tải lên: 09/08/2014, 23:20

... global loss of acetylation lysine16 and trimethylation of lysine 20 of histone 4 is a com- mon hallmark of human tumour cells [23]. Here, we investigate the pattern of histone 4 acetylation and its localization ... difference in acetylation. Peyer’s patches showed the highest levels of K5 and K16 acetylation. Finally, in biopsies of inflamed bowel and in Peyer’ s patches...

Ngày tải lên: 11/08/2014, 03:20

... global loss of acetylation lysine16 and trimethylation of lysine 20 of histone 4 is a com- mon hallmark of human tumour cells [23]. Here, we investigate the pattern of histone 4 acetylation and its localization ... difference in acetylation. Peyer’s patches showed the highest levels of K5 and K16 acetylation. Finally, in biopsies of inflamed bowel and in Peyer’ s patches...

Ngày tải lên: 11/08/2014, 06:22

... Developmental and Psychiatry Centre, Institute of Psychiatry, London, UK. 4 Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, J 5, Mannheim, Germany. 5 Department ... Psychology, University of Southampton, Southampton, UK. 15 Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, S...

Ngày tải lên: 11/08/2014, 15:22

... 3,5,7-trihydroxy-2-(4- hydroxyphenyl)-4h-chromen-4-one, 5-hydroxy-2-(4-hydrox- yphenyl)-1-benzofuran-7-carbonitrile, 3,3',5,5'-tetraiodothy- roacetic acid, 3,5,7,3',4'-pentahydroxyflavone ... bio-ligands An early bio-ligand is defined as that owned by both prokary- otic (E. coli) and eukaryotic (yeast or higher) species, while a late bio-ligand is defined as that owned o...

Ngày tải lên: 14/08/2014, 08:20

... 1 and 6 base- pairs (bp)) in DNA sequences. They can be found in any genome (both eukaryote and prokaryote) and in any region (protein coding regions and non-coding regions). Histori- cally, ... (repeat type), N(M t ) is the expected number of times that, in a DNA segment of length N, we find t consecutive Ms, L is the length of M, and p(M) is the probability of M (obtained...

Ngày tải lên: 14/08/2014, 16:21

... divided it by the total number of synonymous and non-synonymous positions analyzed (Figure 2 and Additional data file 1). In the two types of regions, the frequency of non- synonymous substitutions ... frequency of syn- onymous and non-synonymous substitutions inside repeats and in repeat adjacent regions. We identified all the synony- mous and non-synonymous nucleotide chan...

Ngày tải lên: 14/08/2014, 16:21