Báo cáo y học: "Gene expression-based screening for inhibitors of PDGFR signaling" potx

... increasingly of interest to modulate the activity of particular signal transduc- tion pathways, but the components of such pathways are in many cases only partially known. It would therefore be of interest ... proof -of- concept efforts to approach the discovery of inhibitors of signal transduction using a novel chemical genomic approach. We discovered a previously unknown prope...

Ngày tải lên: 14/08/2014, 08:20

... FC, Verweij CL: Discovery of distinctive gene expression profiles in rheumatoid synovium using cDNA microarray technology: evidence for the existence of multiple pathways of tissue destruction ... reasonably obtained. Surprisingly, information about the amount of blood needed to produce an analyzable sample has not been uniformly reported; one group used lymphocytopheresis, suggesti...

Ngày tải lên: 09/08/2014, 01:23

... genetic synovectomy, and it is the latest development in the tradition of synovectomy, as performed surgically, chemically or by radiation therapy. In RA the fibroblast-like type B synoviocyte is ... the synovium can transform into an invasive tissue (pannus) that destroys cartilage and bone. Synovectomy of a joint, performed surgically, chemically or by radiation therapy, immediately sto...

Ngày tải lên: 09/08/2014, 01:24

... cate- gory testing on GO analysis. The techniques developed here apply more generally, however, to any analysis that looks for over-representation of some category of interest amongst differentially ... analysis for microarray data, the null proba- bility distribution does not conform to a standard distri- bution, precluding an analytical solution for determining the probability of...

Ngày tải lên: 09/08/2014, 20:21

... calculated by analysis of variance of the log-transformed, normalized expression. In the interests of speed, age and sex of animals were not included as cofactors in the analysis of variance. ... imply anything about their suitability for other purposes. In addi- tion, modifications of any of those methods might make them more suitable for QTL mapping. It is not clear why pr...

Ngày tải lên: 14/08/2014, 14:21

... overall efficiency of transgenesis (taking into account embryo loss in vitro and in vivo) is typically ca. 2% [9, 10, 11]. This level of efficiency is perfectly practicable for animal transgenesis, ... simply by the physical injection of a solution of cloned DNA into zygote pronulei [4]. Subsequently, Int. J. Med. Sci. 2004 1(2): 76-91 79 pronuclear microinjection is simply...

Ngày tải lên: 03/11/2012, 10:01

... Impact of remission definition and symptom type. Am J Psychiatry 2000, 157:816-818. 25. Biederman J, Petty C, Fried R, Fontanella J, Doyle AE, Seidman L, Faraone SV: Impact of Psychometrically-Defined ... diagnosis of adult ADHD, the subject must have (1) met full DSM-IV criteria (at least 6 of 9 symptoms) for inattentive or hyperactive/impulsive subtypes, with the onset of multip...

Ngày tải lên: 08/08/2014, 21:20

... In vitro data were analyzed by one-way analysis of variance followed by Tukey post hoc analysis or nonparametric Wilcoxon for paired sam- ples when appropriate. P values of less than 0.05 were ... hGR may vary considerably between different types of cells [20]. Thus, the local proinflam- matory milieu in an inflamed joint might contribute to the cell type-specific effect of locally...

Ngày tải lên: 09/08/2014, 01:22

... Apoptosis and cell phenotype were evaluated by immunohistochemistry and dual-immunofluorescence in synovial biopsy sections from 12 RA patients before and after a mean of 11 days of an intra-articular ... In vitro data were analyzed by one-way analysis of variance followed by Tukey post hoc analysis or nonparametric Wilcoxon for paired sam- ples when appropriate. P values of less th...

Ngày tải lên: 09/08/2014, 13:22

... of PLGA, thus the function of the intracellular drug delivery system can be modified. Therefore, this NPs-mediated drug delivery system works as an excellent ex vivo delivery of rapamy- cin for ... morphology were determined by dynamic light scattering methodology and electron microscopy. In vitro cytotoxicity of blank, rapamycin-loaded PLGA (RPLGA) NPs was studied using MTT Assay....

Ngày tải lên: 10/08/2014, 09:21