Báo cáo y học: "Innate recognition of non-self nucleic acids" ppsx

... secretion of type I interferons by pDCs and the differentiation of B cells into plasma cells. Such a mechanism is likely to be the cause of pDC secretion of type I interferons in systemic lupus erythematosus ... underlying the sensing of cytosolic DNA by DAI and other possible factors have not yet been established and await further investigation. Eventually, research on innate reco...

Ngày tải lên: 14/08/2014, 08:20

... mg/kg/day 6.4 mg/kg/day 3 mg/kg/day Start Onset of symptoms Onset of symptoms Onset of symptoms Duration 7 days 35 days 5 days Effect on inflammation No No No Effect on cartilage damage Yes No ... DK, Marks SC Jr, Choi Y: Diverse roles of the tumor necrosis factor family member TRANCE in skele- tal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed...

Ngày tải lên: 09/08/2014, 01:23

... lung parenchyma of emphysema patients [13]. More recently, our laboratory demonstrated the presence of MMP-1 mRNA, protein and collagenase activity within the lung parenchyma of patients with emphysema ... the lung in emphysema. Conclusion Our scope of understanding of the basic pathophysiol- ogy of emphysema has advanced significantly in the past decade. It is becoming increasing...

Ngày tải lên: 12/08/2014, 18:20

... airways, such as asthma, has only recently been addressed [3]. Asthma is characterized by chronic inflammation of the airways with eosinophils and T helper lymphocytes associated with bronchial hyper-responsiveness, ... a reversible form of airway obstruction after inhalation of a variety of stimuli. Airway obstruction with increased airway resistance in asthma, which is commonly thou...

Ngày tải lên: 12/08/2014, 18:20

Ngày tải lên: 13/08/2014, 11:22

... similarly to the motif at the 3¢-OH primer end of the dsDNA bound to DNA polymerase. What could be the role of this transition in the DNA ligase catalysis? DYNAMIC MECHANISM OF NICK RECOGNITION BY ... (2000) Crystallization and preliminary X-ray crystallographic analysis of NAD + -dependent DNA ligase from Thermus filiformis. Acta Crystallogr. D Biol Crystallogr. 56, 357–358. 21. Lee...

Ngày tải lên: 21/02/2014, 01:21

... is translocated by an insertion–deinsertion cycle of SecA into the SecYEG translocon [8]. Energy for the translocation process is provided by ATP hydrolysis by SecA [8,9] and by the proton-motive ... cleavable signal sequences prevents recognition by SRP and is thereby, together with the hydrophobicity of the signal sequence, a determinant of the targeting pathway. Keywords: outer-mem...

Ngày tải lên: 08/03/2014, 09:20

... inflammatory challenge by altering production of proinflammatory and anti-inflammatory cytokines and may also affect cytokine signaling by a variety of mechanisms, including induction of SOCS-3 [33]. In ... University Hospital, Geneva, Switzerland 3 Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, Switzerland Corresponding author: Cem Gabay,...

Ngày tải lên: 09/08/2014, 08:22

... study of the efficiency of routine elective lymphadenectomy in management of malig- nant melanoma. Cancer 1978, 41:948-956. 43. Santin A: Routine Lymph Node Dissection in the Treatment of Early ... Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species. FASEB J 1997, 11(5):388-95. 32. Kasahara Y, Iwai K, Yachie A, Ohta K, Konno A, Seki H, Miy...

Ngày tải lên: 11/08/2014, 10:23

... Commentary Shock is a syndrome, which is characterized by inadequate tissue perfusion. Shock can have a variety of underlying causes, including hypovolemia, sepsis, cardiac pump dysfunction, ... study in favor of the intervention. Importantly, the unadjusted p-value (p=0.035) for the study’s primary outcome, hospital mortality, was one-sided. The authors explain that a one-sided a...

Ngày tải lên: 12/08/2014, 23:23