Báo cáo y học: " Correction of technical bias in clinical microarray data improves concordance with known biological information" pptx
Báo cáo y học: " Correction of technical bias in clinical microarray data improves concordance with known biological information" pptx
... counted. Bias correction increases consistency of correlation with ER status within five clinical breast cancer studiesFigure 6 Bias correction increases consistency of correlation with ER status within ... onconsideration of the processes involved in the generation of microarray data, but other variables, such as those used tojustify the exclusion of outlying arrays, may also quantify technical bias [24]. ... when seeking information about apredetermined set of genes with known biological function)such extreme filtering may eliminate valuable information, in which case correction of noisy data would...
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Báo cáo y học: " Improvement of platelet dysfunction in chronic myelogenous leukemia following treatment with imatinib: a case report" pps
... the atypical micromegakaryocytes that areprevalent in Ph+CML were significantly reduced afterimatin ib therapy with a further reappearance of normal-sized megakaryocytes.The study by Nolte ... Bergwelt-Baildon*AbstractIntroduction: In patients with chronic myeloid leukemia, tyrosine kinase inhibitors suppress the BCR-ABL+cloneand often induce complete molecular remissions. Megakaryocytes in such ... BCR-ABL protein with constitutive tyrosinekinase activity. Tyrosine kinase inhibitors such as imati-nib are able to suppress the BCR-ABL+clone and inducemolecular remission. Megakaryocytes are...
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Báo cáo y học: "Inhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptides" pptx
... conical polystyreneComparative analysis of inhibition of lentiviral and retroviral vector infectivityFigure 5Comparative analysis of inhibition of lentiviral and retroviral vector infectivity. Percent ... gastrointestinal tract,lung and skin play a key role in protecting the body froma hostile environment [1]. The low incidence of infectionat normal epithelial surfaces reflects the presence of innate, ... HDPsrepresenting different classes for inhibition of early, Env-independent steps in the HIV replicationcycle. A lentiviral vector-based screening assay was used to determine the inhibitory effect of...
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Báo cáo y học: "Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy" ppsx
... 70-merValidation of DNA microarray expression data by qRT-PCRFigure 3Validation of DNA microarray expression data by qRT-PCR. The mean log10 ratios of selected genes from microarray expression data (grey bars) ... the microarray hybridizations performed in this study, partici-pated in the bioinformatic analyses of microarray data anddrafted the manuscript. AHO helped in the design of qRT-PCR assays. ... of cDNA microarray data. Methods 2003, 31:265-273.85. Smyth GK, Michaud J, Scott HS: Use of within-array replicatespots for assessing differential expression in microarray experiments. Bioinformatics...
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Báo cáo y học: "Correction: End-expiratory lung volume during mechanical ventilation: a comparison with reference values and the effect of positive end-expiratory pressure in intensive care unit patients with different lung conditions" pdf
... 2008, 12:R145. Correction Correction: End-expiratory lung volume during mechanicalventilation: a comparison with reference values and the effect of positive end-expiratory pressure in intensive care ... GommersD: End-expiratory lung volume during mechanical ventilation:a comparison with reference values and the effect of positiveend-expiratory pressure in intensive care unit patients with different ... online http://ccforum.com/content/13/6/430Page 1 of 2(page number not for citation purposes)Following the publication of our article [1] we noticed thatthree of the figures were incorrectly...
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Báo cáo y học: "Delta inflation: a bias in the design of randomized controlled trials in critical care medicine" ppsx
... efficacy in trials in critical caremedicine, a finding the authors attributed to the use of mortality as an endpoint [1]. We extend this work byidentifying a key feature of such trials, namely that ... Shu V, Zwingelstein C, Tobias J, Poole L, Stolzenbach JC, Creasey AA, OPTIMIST Trial Study Group: Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: ... be chosen by investigators in the design of a trial of mortality in order to determine therequired sample size, including the significance levelrequired for rejection of the null hypothesis;...
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Báo cáo y học: " Predictors of hepatic steatosis in HBeAg-negative chronic hepatitis B patients and their diagnostic values in hepatic fibrosis"
... patients with clinically and pathologically proven steatosis and 98 patients without steatosis were recruited into this study. The levels of fasting blood glucose (FBG), fasting insulin (FINS), ... fixed in buffered formalin, embedded in paraffin, and stained with hematoxylin-eosin-safran and Masson's trichrome. Hepatic steatosis, stage of fibrosis and grade of disease activity were ... levels of serum alanine aminotransferase (ALT). The higher prevalence of hepatic steatosis in Hispanics was mainly due to the higher prevalence of obesity and insulin resistance in this ethnic...
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Báo cáo y học: "Management of HBV Infection in Liver Transplantation Patients"
... efficacy of combination LAM and HBIG remain poorly defined. Postulated mechanisms include the synergy of: 1) LAM reducing HBV replication and altering synthesis of HBsAg necessary for generation of ... finding of circulating HBV DNA by PCR in 2 of 11 receiving HBIG and 5 of 10 receiving LAM suggests that reinfection would be likely in additional patients with longer observation. Discontinuation of ... deaths occurred within 6 months of initiating therapy [52]. Bilirubin, creatinine and detectable serum HBV DNA were independent predictors of death within the 6 month period. In contrast, the...
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Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc
... MU-meta-bolites in the inhibition of HA synthesis by MU in FM100cells. These above results indicate that something requiredfor a fully functional HA synthesis system is down-regulatedor inhibited in intact ... level of the hasoperon containing the hyaluronan synthase gene or theprotein level of hyaluronan synthase. Solubilization of theenzyme from membranes of MU-treated cells and addition of the ... immunoblotting,proteins were transferred to a polyvinylidene fluoridefilter (Millipore Japan, Tokyo, Japan), and stained with anti-spHAS antibody according to the method of Towbinet al.[35]using3,3¢-diaminobenzidine...
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Báo cáo Y học: Role of tyrosine 238 in the active site of Rhodotorula gracilis D-amino acid oxidase A site-directed mutagenesis study docx
... half-reaction of Y2 38 mutants with D-alaninewas measured by mixing anaerobically a solution of eachmutant enzyme with solutions containing varying concen-trations of D-alanine, such that ... Biology, University of Insubria, Varese, Italy Y2 38, one of the very few conserved residues in the active site of D-amino acid oxidases (DAAO), was mutated to phe-nylalanine and serine in the ... kinetics with D-alanineThe ability of the Y2 38 mutants to catalyseD-alanine/oxygen catalysis was measured by enzyme-monitoredturnover [21]. Air-saturated solutions of Y2 38 mutantenzymes and of D-alanine...
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