Báo cáo y học: "Molecular basis of telaprevir resistance due

Báo cáo y học: "Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus" pdf

... in the ligand binding pocket, similar to the placement of the cyclopropyl group of CPX in 1RTL . The cyclopropyl group is buried in the surface cavity and faces towards the aromatic ring of F43. ... displacement of the side chain of this residue, thereby changing the shape of the cavity. Thus, the V36 mutants affect only the shape of the cyc...

Ngày tải lên : 14/08/2014, 08:20

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Báo cáo y học: " Theoretical basis for reducing time-lines to the determination of positive Mycobacterium tuberculosis cultures using thymidylate kinase (TMK) assays" ppt

... shorten the time-lines to positive identification of microbial cultures (and possibly of other cell lines including cancers). Specifically: if variations in TMKmyc during the S phase of the tubercle ... tubercle bacillus cell cycle are independent of the time taken by the tubercle in other stages of the cycle, then TMKmyc assays are a potential Predicted pattern...

Ngày tải lên : 13/08/2014, 16:21

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Báo cáo y học: "Hypoxic conditions increase hypoxia-inducible transcription factor 2α and enhance chondrogenesis in stem cells from the infrapatellar fat pad of osteoarthritis patients" pps

... β-actin, 5'- AAGCCACCCCACTTCTCTCTAA-3' (forward) and 5'-AAT- GCTATCACCTCCCCTGTGT-3' (reverse); COL1A2, 5'- TTGCCCAAAGTTGTCCTCTTCT-3' (forward) and 5'-AGCT- TCTGTGGAACCATGGAA-3' ... 0.05. Results Isolation, culture and cell surface epitope characterisation of IPFP cells The cells isolated from the IPFP proliferated in culture and reached...

Ngày tải lên : 09/08/2014, 10:20

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Báo cáo y học: " Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects" pptx

... formed by cyclins (regulatory subunits) associated with cyclin-dependent kinases (catalytic subunits; Figure 1). The effect of seliciclib (CYC202; Table 1 and Additional File 1), a cyclin-dependent ... made with the use of a cell cycle peptide inhibitor, the p21 Waf/Cip1 mimic [40]. As the expression of the cyclin-dependent kinase inhibitor p21 Waf/Cip1 is decreased in lym...

Ngày tải lên : 09/08/2014, 14:21

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Báo cáo y học: "Effects on heart pumping function when using foam and gauze for negative pressure wound therapy of sternotomy wounds" pptx

... pumping function. Hitherto, the effect of NPWT on the pumping function of the heart has only been examined using foam [7-10]. The aim of the present study was therefore to compare the haemodynamic ... out- wards to a greater extent when using foam than when using gauze. NPWT using foam may relieve tension on the caval and lung veins in the bottom of the thora...

Ngày tải lên : 10/08/2014, 09:23

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Báo cáo y học: " Candida soluble cell wall β-glucan facilitates ovalbumin-induced allergic airway inflammation in mice: Possible role of antigen-presenting cells" ppt

... may lead to the scenario that CSBG can synergisti- cally increase the number of APCs recruited into the lung in asthmatic mice, and, in turn, can amplify the functional activation of APCs including ... cells was Protein levels of cytokines and chemokines in the lung homogenatesFigure 4 Protein levels of cytokines and chemokines in the lung homogenates. Th...

Ngày tải lên : 12/08/2014, 14:20

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Báo cáo y học: "Human meniscus cells express hypoxia inducible factor-1α and increased SOX9 in response to low oxygen tension in cell aggregate culture" ppsx

... 5'-3' AAGCCACCCCACTTCT-CTCTAA Reverse 5'-3' AATGCTATCACCTCCCCTGTGT COL1A2 Forward 5'-3'TTGCCCAAAGTT-GTCCTCTTCT Reverse 5'-3' AGCTTCTGTGGAACCATGGAA COL2A1 Forward ... inhibition of hypoxic induction of P4H in meniscus cell aggregatesYC-1 mediated inhibition of hypoxic induction of P4H in meniscus cell aggregates. Ratio of hypoxia (5% oxyge...

Ngày tải lên : 09/08/2014, 10:20

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Báo cáo y học: "T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis" docx

... significantly induces the synthesis of IL-6 by synoviocytes and macrophages. A positive feedback loop initiates and accelerates the progression of CIA. Modula- tion of inflammatory cytokines and IL-17 by ... 5'-ACCAGAGGCATAC AGGGACAA-3' IFN-γ 5'-GAAAGACAACCAGGCCATCAG-3' 5'-TCATGAATGCATCCTTTTTTGC-3' IL-4 5'-CCACGGAGAACGAG CTCATC-3' 5&apos...

Ngày tải lên : 09/08/2014, 13:22

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Báo cáo y học: "Class-switched B cells display response to therapeutic B-cell depletion in rheumatoid arthritis" docx

... patients. Discussion Convincing clinical success of therapeutic depletion brought the B cells back into the research focus of RA pathogenesis. The present data indicate that concentrations of one of their products, ... well as the repletion kinetics of switched MemB in the blood and their migration into joints are linked to inflammatory activity. In the following...

Ngày tải lên : 09/08/2014, 14:20

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Báo cáo y học: "Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells" doc

... model system with standardised concentrations of specific AGEs such as CML and pentosidine. AGE-BSA is actively incorporated into cultured FLS and induced to cell cycle arrest, decreased cell ... on cell cultures of human FLS as an accepted in vitro model. We investigated the capacity of AGE-BSA to modulate cell cycle, proinflammatory changes and osteoclastogenesis in...

Ngày tải lên : 09/08/2014, 14:22

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