Báo cáo y học: " Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity" pot

... sketch of the hypothetical map of pathophysiological interactions taking place in obese WATFigure 15 A sketch of the hypothetical map of pathophysiological interactions taking place in obese ... observed in the cell culture study that a panel of inflammatory cytokines, including interleukins and their inducers (members of the interferon family), acute phase proteins...

Ngày tải lên: 14/08/2014, 08:20

... cell motility. We have previously shown that increasing the levels of CLDN-1 increases the invasion of melanoma cells (4). To determine if the increase in claudin-1 needs to be cytoplasmic ... expression of claudin-1 in the cytoplasm, with some nuclear expression of claudin-1. B) Treatment of these cells with PKA inhibitor results in nuclear translocation of cl...

Ngày tải lên: 03/11/2012, 11:17

... determined by flow cytometry after surface stain- ing or intracellular staining with anti -human- specific Abs conjugated with either phycoerythrin or fluor escein isothiocyanate. These human Abs included ... mAbs in the presence of the indicated cytokines, either alone or in various combinations for 7 d. * p < 0.01 compared with their corresponding controls with no cytokines....

Ngày tải lên: 12/08/2014, 13:22

... essential role in the activity of the enzyme, most likely as the residue phosphorylated by ATP. Phosphorylation of Cl -ACL In order to investigate the reaction mechanism of prokary- otic ACL, we examined ... phosphorylated. The phosphory- lation of the AclA protein may lead to a slight decrease in stability of the protein. As no signals were detected in the c...

Ngày tải lên: 08/03/2014, 22:20

... sequences of the naturally occurring cyclic MccJ25 anditslinearvariants.MccJ25-L 1)21 is the thermolysin-linearized MccJ25, previously named MccJ25-L in [19]. MccJ25-L 12)11 displays the sequence of the ... crab pincer-like regions described in the MccJ25 structure [20] are not maintained in the linear form. Thermolysin cleaves the Phe21–Val1 bond, thus the loss of...

Ngày tải lên: 23/03/2014, 21:20

... (1999) Site- directed spin labeling study of subunit interactions in the a-crys- tallin domain of small heat-shock proteins – comparison of the oligomer symmetry in aA-crystallin, HSP 27, and HSP ... doi:10.1046/j.1432-1033.2002.03049.x consisting of the a-crystallin domain alone [HspH(a)], the a-crystallin domain plus the N-terminal region [HspH(Na)], or the a-crystal...

Ngày tải lên: 31/03/2014, 21:21

... participated in the stage of designing the study and recruitment of the study subjects. NT supervised the study and refined the analyses. YY, GS, and NT wrote the manu- script. All the authors read the ... Chowdhury M, Nastasi L: Preliminary test- reset reliability of the KID-SCID. In Scientific Proceedings of the 44th Meeting of the American Academy of C...

Ngày tải lên: 08/08/2014, 23:21

... cells in pathogen-induced chronic inflammatory joint diseases. Any inflammation will cause the induction of chemokine and cytokine production in several tissue- associated cells in the joint, including ... elusive. Relevance of the findings The question of whether our findings are of any significance for the understanding of CIJD is justified and needs answering....

Ngày tải lên: 09/08/2014, 01:23

... boundary, while the other end is within the intron sequence [37]. These so- called half mirtrons may be processed by a combination of the splicing machinery and the microprocessor com- plex. There ... hairpin sequences conserved in C. savignyi so that both miR and miR* products are conserved. Interestingly, only 11 of these correspond to the 41 known C. intestinalis family mem...

Ngày tải lên: 09/08/2014, 20:21

... in DNA binding and the amount of DNA bending that they induce [1].  e MADS-box family subsequently diversifi ed in remarkably diff erent ways in the various eukaryotic lineages during evolution. ... with the minor groove of DNA is mediated by the amino-terminal extension, while one face of the α-helix contacts the major groove. MADS-domain proteins, including th...

Ngày tải lên: 09/08/2014, 20:22