Báo cáo y học: " The SeqFEATURE library of 3D functional site models: comparison to existing methods and applications to protein function annotation" pot

... Article R8 Method The SeqFEATURE library of 3D functional site models: comparison to existing methods and applications to protein function annotation Shirley Wu * , Mike P Liang † and Russ B Altman *‡§ Addresses: ... introduced by Liang et al. [34] in a single application to calcium binding by EF-hand motifs, and is extended and applied here into a f...

Ngày tải lên: 14/08/2014, 08:20

... phenotype analysis of a crr mutant, protein protein interaction studies with candidate proteins, and the determination of the levels of nonphosphorylated/phosphorylated IIA Crr in relation to the nutritional ... this hypothesis. The demonstration of the IIA Crr –MalK interaction suggests that IIA Crr may regulate the function of some of the > 140 MalK homo...

Ngày tải lên: 17/03/2014, 23:20

... method. The rationale for the development of METs rose from observations that, in the majority of patients, premonitory signs and symptoms of cardio- pulmonary instability are often present hours before ... debriefing to fill out the standardized MET form on each patient and a weekly 1-hour Commentary The evolving story of medical emergency teams in quality improvement...

Ngày tải lên: 25/10/2012, 10:06

... beneath the hair follicles and subcutaneous fat of the temporal region. This fascia is attached superiorly to the superior temporal line and inferiorly to the lateral and medial surfaces of the ... located deeper at the level of the ear and approximately 10 cm above the crus helix, they take a more superficial course entering the subdermal plexus. 8...

Ngày tải lên: 25/10/2012, 11:00

... belongs to the family flaviviridae.[7] HCV replicates in the cytoplasm of hepatocytes, but is not directly cytopathic. Persistent infection appears to rely on rapid production of virus and continuous ... disease or grade, is gauged by the number of mononuclear inflammatory cells present in and around the portal areas, and by the number of dead or dying hepatoc...

Ngày tải lên: 02/11/2012, 09:56

... covers the fifth and sixth weeks of gestation (i.e. the first part of the second month) and the protective effect of folic acid needs some time to achieve the necessary blood level. Of 8 other ... among others, medicine intakes, pregnancy complications, and maternal diseases during pregnancy according to gestational month, and any family history of CAs. In o...

Ngày tải lên: 03/11/2012, 10:05

... inhibitory region of TnI to influence the surface activity of actin towards other actin binding proteins. The site of binding of the inhibitory region is the N-terminal of actin that is structurally ... actin and tropomyosin at low ionic strength and in the absence of added magnesium. Earlier reports of the stimulatory effect of tropomyosin on the inhibito...

Ngày tải lên: 17/03/2014, 10:20

... residues. The presence of three charged residues (Arg5, Lys8, and Lys19) distributed on each side of the s heet reduces considerably the hydropho- bicity of the surface of androctonin when compared to ... tends to adsorb in the headgroup region of the membrane, leading to a decrease of the thickness of the lipid bilayer, and then to (b) an active stat...

Ngày tải lên: 17/03/2014, 23:20

... Alignment of the amino-acid sequence of M.MspI also uncovered similarity (residues 245–287) to the active site of human DNA ligase I. To evaluate the role of the N-terminus of M.MspI, 2-hydroxy-5-nitrobenzyl ... M.MspIandthemarkerproteinswere subjected to 10% polyacrylamide gel electro- phoresis in the presence of 0.1% SDS. (B) The mobilities of the marker...

Ngày tải lên: 24/03/2014, 00:21

... e ascribed mainly to the delayed autoxidation of the b chains in acidic pH range. More speci®cally, the b chain h as acquired this stability by blocking out the proton catalysis performed by the distal ... binding of molecular oxygen to the heme iron(II) is the b asis of hemoglobin function. However, the oxygenated form of hemoglobin, as well as of myoglo- bin,...

Ngày tải lên: 31/03/2014, 15:20