Báo cáo y học: "Deciphering histone 2A deubiquitination" doc

... modifications is provided by the activity of Ubp8, a yeast deubiquitinating enzyme which regulates the methylation of histone 3 (H3) on lysine 4 (K4 methylation) by deubiquitinating histone 2B (H2B) [5]. ... damage repair pathways. DNA repair Cell cycle Transcription USP3 H2A H2A Ub Ub USP16 MYSM1 Genome BBiioollooggyy 2008, 99:: 202 Minireview DDeecciipphheerriinngg hhiissttoonnee 22A...

Ngày tải lên: 14/08/2014, 08:20

... pulmonary disease; FLS = fibroblast-like synoviocyte; FoxO = forkhead box class O; GC = glucocorticoid; HAT = histone acetyl transferase; HDAC = histone deacetylase; HDACi = histone deacetylase inhibitors; ... evidence has recently emerged that HDAC activity can also modulate the generation and function of anti- inflammatory thymic-derived natural regulatory T lymphocytes [76]. Systemic...

Ngày tải lên: 09/08/2014, 11:20

... by the ICGEB Proteomics Facility by analyzing the purified peptides by MALDI-TOF mass spec- trometry using an ABI 4800 TOF/TOF instrument (Applied Biosystems). The remaining sample was ana- lyzed ... CDK9- associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell 1998, 92:451-462. 43. Zhu Y, Pe'ery T, Peng J, Ramana...

Ngày tải lên: 13/08/2014, 06:20

... RT-PCR analysis The expression of selected genes was also analyzed by Q-PCR using the TaqMan ® low density Micro Fluidic Card or Taq- Man ® single assays (Applied Biosystems, Foster City, CA, USA), ... order to identify relevant mechanisms that may have important implications for drug efficacy and actively contribute to innate resistance. Thus, high levels of thymi- dylate synthase, the 5-F...

Ngày tải lên: 14/08/2014, 16:21

... day after 5 Gy X-ray exposure 3 Test 5Gy3D Intact planarians 3 day after 5 Gy X-ray exposure 2 Test 5Gy4D Intact planarians 4 day after 5 Gy X-ray exposure 3 Test 5Gy5D Intact planarians 5 day ... planarians 3 day after 30 Gy X-ray exposure 2 Test 30Gy4D Intact planarians 4 day after 30 Gy X-ray exposure 2 Test 30Gy7D Intact planarians 7 day after 30 Gy X-ray exposure 2 Test 5Gy2D Intact plan...

Ngày tải lên: 14/08/2014, 20:22

... and asymmetry in histone modifications How does the asymmetry in histone modifications relate to gene content and gene death in human SDs? The asymmetry of pol II ChIP tags is certainly consistent ... analysis. In any case, the characterization of either SDs without genes or SDs without pol II asymmetry shows that asymmetrical distributions of several histone modifications were not ent...

Ngày tải lên: 14/08/2014, 20:22

... J: Dynamic lysine meth- ylation on histone H3 defines the regulatory phase of gene transcription. Mol Cell 2005, 18:723-734. 66. Reinke H, Gregory PD, Horz W: A transient histone hyper- acetylation ... 7:529-538. 67. Yamagoe S, Kanno T, Kanno Y, Sasaki S, Siegel RM, Lenardo MJ, Hum- phrey G, Wang Y, Nakatani Y, Howard BH, Ozato K: Interaction of histone acetylases and deacetylases in...

Ngày tải lên: 14/08/2014, 21:20

... study period. Peptide-specific IgE was induced in some patients during the study. Skin sensitivity to intradermal allergen challenge did not change signifi- cantly. Peptide therapy was generally ... regulatory cells producing IL-10. 4 ‘‘Natural’’ regulatory T cells arise either in the thymus or peripheral lymphoid organs, whereas Th3 and Tr1 cells appear to arise from naive lymphocytes in ......

Ngày tải lên: 08/08/2014, 21:20

... gastrointestinal, genitourinary, and / or respiratory systems. Progressive upper or lower respi- ratory symptoms, hypotension, and arrhythmias typically de- velop in fatal and near- fatal cases. ... www .foodallergy .org American College of Allergy, Asthma and Immunology http: // www .acaai .org American Academy of Allergy, Asthma and Immunology http: // www .acaai .org Food You Can Eat...

Ngày tải lên: 08/08/2014, 21:20

... University of Calgary, Calgary, Alberta, Canada Bowen Allergy, Asthma & Clinical Immunology 2010, 6:13 http://www.aacijournal.com/content/6/1/13 ALLERGY, ASTHMA & CLINICAL IMMUNOLOGY © 2010 ... Canada an d was cospon- sored by CHAEN/RCAH, the Canadian Society of Allergy and Clinical Immunology, and the University of Calgary and was funded through an unrestricted educa- tional grant f...

Ngày tải lên: 08/08/2014, 21:20