Báo cáo y học: "Contribution of telomerase RNA retrotranscription to DNA double-strand break repair during mammalian genome evolution" pot

... recruitment of ATM, ATR and DNA- PKcs to sites of DNA damage. Nature 2005, 434:605-611. 32. Yan H, McCane J, Toczylowski T, Chen C: Analysis of the Xenopus Werner syndrome protein in DNA double-strand break repair. ... properly cited. Telomerase and DNA repair& lt;p>A comparative analysis of two primate and two rodent genomes suggests that telomerase was utilized...

Ngày tải lên: 14/08/2014, 08:20

... due to the cofactor was significantly lower than that of the wild-type enzyme and, correspond- ingly, the amount of PLP released by NaOH treatment was only 10% of that expected for a fully saturated ... polarity favors the 420 nm-ketoenamine tautomer in the wild-type enzyme and the 330 nm-absorbing hydrated form of PLP in the mutant enzymes. Conversely, the less hydrated environ- men...

Ngày tải lên: 31/03/2014, 08:20

... disorders of the CANS. These were mainly psychiatry and neurology. The assessment of the CANS is also of great value concerning neuropsychol- ogy and special education [4–6]. Anatomy and physiology of ... of professionals in psychiatry, neurology, neuropsy- chology and pediatric psychology, with the otolaryngologist-audiologist is a prerequisite. Central au- ditory processing disord...

Ngày tải lên: 08/08/2014, 20:23

... interaction of KIR3DL1 and Bw4-I80 has an inhibitory effect on the cytotoxic capacity of NK cells. All HLA-B27 subtypes carry Bw4 epitope, with the exception of B*2708 and other related sub- types, ... may imply a role in inflammatory disease. Binding of the KIR3DL1 receptor to the Bw4 family of MHC class I receptors has been shown to be dependent on key res- idues of the HC a...

Ngày tải lên: 09/08/2014, 08:22

... of Cys67 of the B27 molecule [20-22]. It has been argued that alternative recognition of different forms of HLA-B27 by KIR or ILT could influence their immunomodulatory function and may imply ... may imply a role in inflammatory disease. Binding of the KIR3DL1 receptor to the Bw4 family of MHC class I receptors has been shown to be dependent on key res- idues of the HC aroun...

Ngày tải lên: 09/08/2014, 08:22

... 3' ends of the viral DNA to the host DNA; and (3) gap repair, when the 5' ends of the viral DNA are joined to the host DNA by the host DNA repair enzymes. Integration of the viral DNA into the ... lethal phenotype may be related to the cat- alytic activity of IN, as an IN catalytic mutant (D116A) was unable to induce lethality in yeast [27,28]. However...

Ngày tải lên: 13/08/2014, 05:21

... of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada, 2 Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada and 3 Laboratory of Human ... IN cDNAs har- boring specific mutations were then cloned into pEYFP- N1 vector. To improve the expression of each IN-YFP fusion protein, all IN-YFP fusing cDNAs were finally sub- cl...

Ngày tải lên: 13/08/2014, 09:21

... potential application of this approach to crop breeding is to identify key regulatory mutations conferring desirable, yet highly pleiotropic, traits in commercial culti- vars. Regulatory polymorphisms ... and methods) to determine whether any of the polymor- phisms altered sequences corresponding to known cis- regulatory motifs in the promoters. We found that a total of 44 out...

Ngày tải lên: 14/08/2014, 14:21

... mountains of the Appennine range divide Parma Province from Tuscany and from Ligury, and Po river flows through its territory. The territory of Parma Province presents two types of en- vironment: ... Ivyspring International Publisher. All rights reserved Short Communication Incidence of Ocular Zoonoses referred to the Inflammatory and Autoim- mune Ocular Diseases Service of t...

Ngày tải lên: 03/11/2012, 11:11

... dehydrogenase activity speci®cally involved in the glyoxylate cycle is attributed to the cytosolic isoform Mdh2p [7]. The suggestion of an extra-peroxisomal location for the yeast g lyoxylate cycle ... the issue of the partitioning of the glyoxylate cycle in cells grown under fatty acid-medium conditions has hitherto remained open. We showed here that one of the key glyoxylate-cycle...

Ngày tải lên: 22/02/2014, 04:20