Báo cáo y học: "Identification of candidate predictive and surrogate molecular markers for dasatinib in prostate cancer: rationale for patient selection and efficacy monitoring" doc

... targets, including Abl, c-kit and PDGFR kinases, showed minimal efficacy in early clinical testing with a small number of patients [19,20]. Identification of these preclinical candidate markers and ... R255 Research Identification of candidate predictive and surrogate molecular markers for dasatinib in prostate cancer: rationale for patient selec...

Ngày tải lên: 14/08/2014, 08:20

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Ngày tải lên: 09/08/2014, 20:22

... Culture and Stem cell culture Primary mixed glial cultures were prepared from the brains of newborn rats > 3 days old by dissociation of whole cortex in trypsin, then cultured in poly-D-lysine coated ... specificity, cotranslational packaging and competition for limiting Gag polyprotein [13]. These differences in the location of the major packaging determinants may contri...

Ngày tải lên: 13/08/2014, 09:21

... prescription of ChEIs has not yet been studied systematically. Therefore the main question of this study is: Do geriatric comorbidity and polypharmacy influence the prescription of ChEIs in patients ... galantamine) in the incidence year. Our main independent variables were polypharmacy and measures of geriatric comorbidity. The concurrent use of multiple drugs is ofte...

Ngày tải lên: 11/08/2014, 16:21

... (IC50) of full-length DNA synthesis. Determination of steady-state kinetic parameters The Km for dATP and the Ki for TFV-DP were determined by filter binding assays as described previously [36]. In brief, ... resolved in 6% polyacrylamide-7M urea gel and ana- lyzed by using the Molecular Dynamics Typhoon Phos- phorimager system (GE Healthcare). To study the effect of mutat...

Ngày tải lên: 13/08/2014, 05:21

... a candidate citrullinated protein by immunoblotting lysates of monocytic and granulocytic HL-60 cells treated with peptidylarginine deiminase. In an initial screen of serum samples from four patients ... that stained positively for enolase, although the intensity of the staining indicated that levels of citrullination were relatively low. Immu- noblotting of synovial cell ly...

Ngày tải lên: 09/08/2014, 07:20

... Robert Haynes for the countless hours spent in caring for and maintaining precise records of these RI lines and Sung Kim for his help in analyzing the function and pathway associations of selected ... Paraffin-embedded sections were de-paraffinized by immersing in xylene, followed by dehy- drating in ethanol. The tissue sections were prepared and stained with hemato...

Ngày tải lên: 09/08/2014, 13:22

... of up- per/lower endoscopy in outpatients with iron defi- ciency anemia. The aim of our study was to investi- gate the incidence of GI pathological findings in symptomatic and asymptomatic patients ... deficiency. All patients were interrogated and examined according to Form-1 in Figure 1. This form developed by us for this study. The presence of dyspeptic com- plaint...

Ngày tải lên: 25/10/2012, 11:18

... use of yeast two hybrid system, which is a genetic assay for in vivo detection of interactions of proteins, enables identification of protein- protein interactions between a soluble bait and ... and its interacting prey [5]. However, such a screening system is not suitable for the analysis of interaction between membrane bound proteins. The split-ubiquitin yeast two...

Ngày tải lên: 02/11/2012, 11:08

... 2 Flow cytometric analysis of combinations of progenitor markers on freshly isolated and culture expanded chondrocytes from osteoarthritic cartilageFlow cytometric analysis of combinations of progenitor ... penicillin, 100 µg/ml streptomycin; Bio- chrom, Berlin, Germany); fine mincing and digestion with 0.2% pronase (Roche, Mannheim, Germany) for 45 min at 37°C; and two furt...

Ngày tải lên: 09/08/2014, 01:23