Báo cáo y học: "Using protein complexes to predict phenotypic effects of gene mutatio" pps

... that of random pairs. To com- pare intersections of predictors to single predictors, the expected frequency was the greater of the two predictors alone. To compare intersections of predictors to ... 'phenotype pairs', that is, pairs of genes whose loss leads to similar phenotypic profiles. If we could identify an effective predictor of phenotype pairs, and if...

Ngày tải lên: 14/08/2014, 08:20

... sig- naled by cytokines [20,21]. More specifically, the expres- sion of inducible genes leading to the synthesis of cytokines, chemokines, chemokine receptors, adhesion molecules, enzymes and autacoids ... 1 Surgery I Department. Medical School, Complutense University, 28040 Madrid, Spain, 2 Psychobiology Laboratory, School of Psychology, University of Oviedo, Asturias, Spain and...

Ngày tải lên: 13/08/2014, 16:21

... and the wild-type proteins were tested for enzymatic activity ) only the wild-type protein displayed activity. Consistent with this lack of activity, atomic absorption measurements of the AMPP#3-22 ... the activity of AMPP [1]. Here, the presence of ZnCl 2 in the dialysis buffer led to the precipitation of each of the three proteins. Neither the intact protein nor the Table...

Ngày tải lên: 23/03/2014, 07:20

... con- trols motility of murine microglial cells in vitro via activation of an inhibitory G -protein and the rearrangement of the actin cytoskeleton. Neuroscience 1996, 73:1091-1107. 47. Yao J, Harvath ... these activation proteins are mediated by numerous regulatory proteins including CD59, clus- terin, vitronectin, C1-inhibitor, C4-binding protein, decay-activating factor, and Factor...

Ngày tải lên: 19/06/2014, 22:20

Ngày tải lên: 09/08/2014, 01:21

... stoichiometric binding of protease inhibitors to the catalytic site of the activated forms of the enzymes. In the present work, we have measured by flow cytometry the net proteolytic activity in synovial fluids ... inflammatory state of the disease Extracellular proteases are secreted in SF by infiltrating inflam- matory cells and/or by stromal cells stimulated by inflammatory cytok...

Ngày tải lên: 09/08/2014, 08:22

... major synchronizer of circadian rhythms to the 24- hour solar day. Disruption of circadian rhythms has been associated with a variety of maladies. Ecological studies of human exposures to light ... light phase). To allow for acclimation to the cages and to the lighting by the rats, wheel-running data were not collected until the third day of the study, by which time the ph...

Ngày tải lên: 10/08/2014, 09:20

... years to < 10 years 21 (17.2) 10 years or longer 50 (41.0) Number of years working in childhood disability Less than 1 year 8 (6.6) 1 year to <5years 24 (19.7) 5 years to <10 years 29 ... to 6 mos 6.1 2.3 to 15.8 <0.01 Baseline to 6 mos 2.7 0.9 to 7.8 0.07 6 to 12 mos 1.0 0.3 to 3.4 0.95 6 to 12 mos 1.2 0.4 to 3.3 0.73 12 to 18 mos 1.0 0.3 to 3.2 0.93 1...

Ngày tải lên: 10/08/2014, 10:23

... bibliography. The rarity of PTBC is not only due to the rarity of Mycobacterium tuberculosis in general, but also because of the difficulty in identifying it in the biopsies taken by endoscopy. It is estimated ... is estimated that only one out of three cases of lower gas- trointestinal tuberculosis giv es a positive identification of the mycobacterium by culture, and two out o...

Ngày tải lên: 11/08/2014, 00:23

... hesitant to get into a protracted struggle with patients to try to convince them of the need for insulin. 'If you're not interested, so be it,' I think by myself. The nurse educator ... impediment to the delivery of quality care, explaining that a pay-for-performance system would be a better motivator. In addition, direct payment by patients was also seen as a signi...

Ngày tải lên: 11/08/2014, 05:21