Báo cáo y học: "Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender" pdf

... Biology 2007, 8:R234 Open Access 2007Xuet al.Volume 8, Issue 11, Article R234 Research Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and ... behaviors, responses to dietary energy intake and susceptibility to age- related dysfunction and disease. Conclusion The factors of age, gender and...

Ngày tải lên: 14/08/2014, 08:20

... IL-1β alone, the combination of TNF-α and IL-17, and the combination of TNF-α and IL-1β. Conclusions Gene expression studies of the RA synovium may be useful in the identification of early markers of response ... immunohistochemistry) in order to verify the reality of their microarray data [30]. Their results were also potentially biased by the fact that the...

Ngày tải lên: 09/08/2014, 14:20

... scrutiny, or their hybrids. Clearly, expression in hybrids is made very complex, for instance, by the generation of a large quantity of abnormal heteromeric proteins [13]. Therefore, analyzing expression ... (non-polymorphic) and, therefore, non-exploitable for QTL mapping [3]. From the A summary of the modes of regulation encountered in the IRCSs and their parent stra...

Ngày tải lên: 14/08/2014, 20:22

... & Therapy Vol 7 No 1 Rioja et al. R116 preparation. CC and SG performed the microarray experi- ments and statistical analysis of the array data. MD and PL carried out the study design and collaborated ... exactly the same (probably due to differences in the sensitivities of the assays), the quantitative real-time RT- PCR TaqMan ® method verified the results o...

Ngày tải lên: 09/08/2014, 06:22

... with IL-1 ββ and TNF- αα on the expression of IL-6 and IL-8 To confirm the array data and the results of real-time RT–PCR on the protein level, we measured the secretion of IL-6 and IL-8 in SFCs ... Interestingly, antisense oligonucleotides of c-myc can induce apoptosis and downregulation of Fas expression in synoviocytes [37]. The present study demonstrate...

Ngày tải lên: 09/08/2014, 01:22

... predicting the prognosis of the dis- ease. The major obstacles in the human studies are the relatively late diagnosis of RA, the large variety of cell types (cells of the immune system and of synovial ... expression profile is extremely complex owing to the diversity of cell types involved in the pathology and the polygenic character of the autoimmune...

Ngày tải lên: 09/08/2014, 06:22

... along the endothelium of postcapillary synovial venulesLeucocytes rolling along the endothelium of postcapillary synovial venules. Shown are the proportions of leucocytes rolling along the endothelium ... 4 Leucocytes adherent to the endothelium of postcapillary synovial venulesLeucocytes adherent to the endothelium of postcapillary synovial venules. Shown are the n...

Ngày tải lên: 09/08/2014, 06:23

... 0.001. Effect of cytokines and nitric oxide on expression and secretion of glycosidases by synovial fibroblasts We tested the effect of various cytokines and nitric oxide on the gene expression of glycosidases. ... and proinflammatory actions, as exemplified by its ability to down- regulate RANTES expression and by stimulating the synthesis of MMP-1 and IL-1...

Ngày tải lên: 09/08/2014, 14:20

... only partially known. We aimed at studying the gene expression profile of circulating endothelial cells and the effects of iloprost infusion and gene expression in patients with systemic sclerosis. Methods: ... detection and enumeration of rare events in flow cytometry are the n umber of events acquired and the signal to noise ratio. Collection of a large num ber...

Ngày tải lên: 12/08/2014, 14:22

... oligonucleotide microarrays to gain gene expression profiles of Nfia -/- mouse brains and of corresponding wild-type samples. Relatively early and late changes in gene expression were measured by quantifying transcript ... cells being obscured by the high expression level of L1 in neurons. In contrast to the peripheral nervous system, glial cells of the central...

Ngày tải lên: 14/08/2014, 07:21