Báo cáo y học: " Chromatin meets RNA polymerase II" pptx

... hipermodified base Y3 7 (wybutine) (Figs 6 and 7). Also other amino- glycosides, as kanamycin A, neomycin B and a synthetic neomycin-neomycin dimer have been shown to induce fragmentation of tRNA Phe at Y3 7 and ... incubation with RNA; lane 21, tRNA Phe +50l M complex + 100 l M H 2 O 2 prepared 1 h before incubation with RNA; L, formamide ladder. Ó FEBS 2002 DNA and RNA dam...

Ngày tải lên: 21/02/2014, 01:21

... 2002 Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1 Implications for apoptosis signaling pathways Takenori Takizawa 1 , Chizuru Tatematsu 1 and Yoshinobu ... S., Kirchhoff,S.,Hauser,H.,Decker,T.&Koromilas,A.E. (19 97) Physical association between STAT1 and the interferon-inducible protein kinase PKR an...

Ngày tải lên: 08/03/2014, 09:20

... chemistry of a tetrahedral methyl carbon in methyl lysine differs substantially from the planar carbonyl carbon of acetyl lysine (Fig. 2B). In fact, it is currently unknown whether lysine or arginine ... modification of this lysine could, in theory, result in either a change in the biophysical properties of chromatin or it could provide regulatory information. Unlike lysine acetyla...

Ngày tải lên: 31/03/2014, 21:21

... DNA REPLICATION-COUPLED CHROMATIN ASSEMBLY The majority of chromatin assembly is tightly coupled to DNA replication in the cell. Accordingly, chromatin assembly systems that preferentially assemble chromatin onto ... chromatin assembly factors that have been identified biochemically and may function to mediate chromatin assembly in vivo: histone chaperones for newly...

Ngày tải lên: 31/03/2014, 21:21

... Genome Biology 2010, 11:R72 http://genomebiology.com/2010/11/7/R72 Page 14 of 16 RESEA R C H Open Access Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes Rebecca ... day; ECR: evolutionarily conserved region; EST: expressed sequence tag; LNCRNA: long noncoding RNA; MIRNA: microRNA; NCRNA: noncoding RNA; ORF: open r...

Ngày tải lên: 09/08/2014, 20:22

... Access Cloud-scale RNA-sequencing differential expression analysis with Myrna Ben Langmead, Kasper D Hansen, Jeffrey T Leek * Abstract As sequencing throughput approaches dozens of gigabases per day, ... [http://bowtie-bio.sf.net/myrna]. doi:10.1186/gb-2010-11-8-r83 Cite this article as: Langmead et al.: Cloud-scale RNA-sequencing differential expression analysis with...

Ngày tải lên: 09/08/2014, 20:22

... article as: Yassour et al.: Strand-specific RNA sequencing reveals extensive regulated long antisense transcripts that are conserved across yeast species. Genome Biology 2010 11:R87. Submit your next ... RESEA R C H Open Access Strand-specific RNA sequencing reveals extensive regulated long antisense transcripts that are conserved across...

Ngày tải lên: 09/08/2014, 20:22

... acceptance. Copyedited and fully formatted PDF and full text (HTML) versions will be made available soon. High-throughput RNA interference screening using pooled shRNA libraries and next generation ... genomic DNA using 30 parallel PCR reactions, each with 2 àg of genomic DNA. shRNA library glycerol stock shRNA library plasmid shRNA library virus Target cel...

Ngày tải lên: 09/08/2014, 23:20

... RESEARC H Open Access Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line Rajesh K Aneja 1* , Hanna Sjodin 2 , ... Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line. Journal of I...

Ngày tải lên: 11/08/2014, 03:20

... 8:3 http://www.journal-inflammation.com/content/8/1/3 Page 6 of 9 RESEARC H Open Access Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast ... Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell...

Ngày tải lên: 11/08/2014, 06:22

... this article as: Ranjan et al., 5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication Virology Journal 2010, ... than virus- specific as they inhibited replication of wild-type and drug-resistant strains of seasonal and avian viruses as well as pandemic inf...

Ngày tải lên: 12/08/2014, 04:20

... infec- tion. For the evolution of viral load, the setpoint theory was introduced soon after the implementation of HIV RNA assays [1,2]. Three components describe the setpoint behaviour after the high ... time depend on the scale that is used to visualize trends. In reconsidering the setpoint theory for HIV RNA, we analyzed the evolution of CD4 T-cell count and...

Ngày tải lên: 13/08/2014, 05:22

... viral RNA behaved differ- ently than predicted by those studying cellular mRNAs. Many of the important discoveries in RNA biology were made by study of viral RNA. The only disadvantage is you have ... scientist and a mother. References 1. Jeang KT: Life after 45 and before 60: the Retrovirology Prize. Retrovirology 2005, 2:26. 2. Jeang KT: The young, not-so-young, and the...

Ngày tải lên: 13/08/2014, 05:22

... Ito M, Tsutsumi Y, Ichikawa Y, Okuyama H, Brisibe EA, Sak- sena NK, Fujii YR: HIV-1 nef suppression by virally encoded microRNA. Retrovirology 2004, 1:44. 80. Bennasser Y, Le SY, Yeung ML, Jeang ... RNA stability, despite imper- fect sequence homology [69,70]. Basically, the miRNA genes are transcribed by RNA polymerase II into pri- mary(pri)-miRNA, which are cleaved by a nuclear RNAse...

Ngày tải lên: 13/08/2014, 09:21

... distantly related fission yeast Schizosaccharomyces pombe. Brad Cairns (University of Utah, Salt Lake City, USA) has used whole-genome tiling arrays to detect small matched DNA -RNA hybrids, thus measuring ... active genes, and plays a role in heterochromatin silencing. H3K4 trimethylation by the complex of proteins associated with the Set1 methylase (COMPASS) and methylation of H3K79 by Dot...

Ngày tải lên: 14/08/2014, 08:20