Báo cáo y học: " Simplified ontologies allowing comparison of developmental mammalian gene expression" pot

... profiles of the 90 genes show- ing bias for developmental expression across major human and mouse tissues in the form of a binary pseudoarray. Additional data file 1Sets of genes analyzed for developmental ... RIKEN, Japan [1]. Data generated by these consortia include microarray, CAGE (capped analysis of gene expression), SAGE (serial analysis of gene expression) and MPSS (...

Ngày tải lên: 14/08/2014, 08:20

... of Pharmacy, University of Maryland, Baltimore, Maryland, USA, 2 Department of Psychiatry, School of Medicine, University of Maryland, Baltimore, Maryland, USA, 3 Departments of Psychiatry ... Health, University of Bremen, Bremen, Germany and 6 Department of Child and Adolescent Psychiatry/Psychotherapy, University Hospital Ulm, Germany Email: Julie M Zito* - jzito@rx.uma...

Ngày tải lên: 25/10/2012, 10:06

... this study, we hypothesized that BALF fibroblasts in SSc display alterations in cell motility which may account for the presence of these cells in the airway lumen. Further- more, we hypothesized ... suggested to be of importance in maintaining the myofibroblast phenotype by inducing increased levels of α-SMA [26]. We did not observe, how- ever, any differences in the production of TG...

Ngày tải lên: 12/08/2014, 16:20

... value gives no indication of the size of any dif- ference; it merely indicates the probability that the difference arose by chance. In order to assess the magnitude of any dif- ference, it is essential ... The t-test formally examines how far the esti- mated mean haemoglobin of men admitted to ICU, in this case 9.7 g/dl, lies from the hypothesized value of 15.0 g/dl. The null hypoth...

Ngày tải lên: 12/08/2014, 19:21

... group. Secondly, nurses with varying experience were responsible for insertion of post-pyloric tubes. This was intentionally done to reflect the day to day practice of the ICU. Thirdly, there was ... insertion of post-pyloric tubes can be time-consuming and costly leading to delays in the ini- tiation of feeds. A number of post-pyloric insertion techniques have been described. The u...

Ngày tải lên: 13/08/2014, 20:21

... GRRPsLFG and APDyTTPEMY-NH 2 were obtained from Dr A ˚ ke Engstro ¨ m at the Peptide Synthesis and Analysis Laboratory of the Department of Medical Biochemistry and Microbio- logy, Uppsala University. The ... combinations of phosphatases and interme- diary phosphorylated enzymes. Therefore, kinetic data on the dephosphorylation of autophosphorylated ATP-citrate lyase in the paper in p...

Ngày tải lên: 21/02/2014, 01:21

... Alcaligenes xylosoxydans ssp. xylosoxydans A-6 N-acyl- D -Asparate amidohydrolase; A-6-D50061: Alcaligenes xylosoxydans ssp. xylosoxydans A-6 N-acyl- D -glutamate amidohydrolase; Alicaligenes faecalis-DA1: ... protein of V. paradoxus is possibly a metal- dependent enzyme. Substrate specificity analysis To study the substrate specificity of the N-D-AAase protein, the activity of the enzyme...

Ngày tải lên: 08/03/2014, 16:20

... peptide-independent pathway and calls for further investigation on this subject. Enzyme activity and specificity In the standard tricaprylin hydrolysis assay, rPFL displayed highest activity at 29 °C and ... wild type enzyme [30]. Interestingly, the enzyme lost most of its activity at 50 °C but retained about 60% of its specific activity at 10 °C (Table 1). Under the same conditions, the ac...

Ngày tải lên: 24/03/2014, 04:21

... regulators of MMPs. These hypotheses will be tested in future. The inhibition of MMP gene expression by mithramycin is not unique to this antibiotic. Interestingly, a tetracycline analogue, doxycycline, ... 26:209-213. 19. Blume SW, Snyder RC, Ray R, Thomas S, Koller CA, Miller DM: Mithramycin inhibits SP1 binding and selectively inhibits tran- scriptional activity of the dihydrofolat...

Ngày tải lên: 09/08/2014, 06:22

... regulation of organ development. Charting the loss of pluripotency Fang et al. also took advantage of the dataset they gener- ated to compare the gene- expression profile of human embryos with that of ... phenotype -gene ontology analysis, Fang et al. also determined that defects in genes in clusters 1 through 3 were, in general, associated with embryonic lethality and defecti...

Ngày tải lên: 09/08/2014, 20:22