Báo cáo y học: " Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo" pptx

... multiplicity testing by con- trolling the false discovery rate [27]. The differences between the transcriptional profiles induced by the six toxicants were less prominent in the datasets from the 4-24 ... numbers of embryos and can thus average the individual gene responses by using pooled cDNA pre- pared from many embryos. In the cases where we confirmed the gene r...

Ngày tải lên: 14/08/2014, 08:20

... the up-regulation of the gene encoding HMG coenzyme-A synthase, an enzyme implicated in juvenile hor- mone biosynthesis and recently linked to the IIS pathway [48]. The gene encoding the ecdysone ... increased in proportion to the increase in MnSOD enzyme activity. Here, a doxycycline (DOX)-regulated promoter system ('tet-on') [18] was used to induce MnSOD, thereby...

Ngày tải lên: 14/08/2014, 08:20

... SRY (sex determining region Y) -box 9 (SOX-9) [11]. However, the distinctive function of the two tissues is determined by the exact composition of the matri- ces synthesised by their native cells. ... KRT19 is also a type I cytokeratin but unlike its related family mem- bers is not paired with a basic cytokeratin [40]. Members of the cytokeratin family are typically expressed by ep...

Ngày tải lên: 12/08/2014, 11:23

...  erapy, Minogue and colleagues [1] used transcriptional profi ling to examine the phenotypic characteristics of bovine intervertebral disc cells and provided some novel insights into the current ... unequivocally that the entire cell population of the nucleus pulposus, even in the adult, was descended from the notochord. Another invaluable marker of the ontology of t...

Ngày tải lên: 12/08/2014, 12:20

... present in a subset of the urogenital mesenchyme including the VMP (marked by arrows in male and female). In females there was staining in the mesenchyme of the Mullerian duct (MD). In males, the ... that androgens may not directly control the expression of paracrine acting factors but may act indirectly, by controlling the interaction of inductive mesenchmye with ep...

Ngày tải lên: 14/08/2014, 08:20

... Late (c) E.YPS3060 M.YPS3060 L.YPS3060 E.YPS3137 M.YPS3137 L.YPS3137 L.YPS3395 E.YPS3395 M.YPS3395 L.YPS2073 E.YPS2073 M.YPS2073 L.YPS183 E.YPS183 M.YPS183 E.YPS2079 M.YPS2079 L.YPS2079 L.YPS2060 E.YPS2060 M.YPS2060 L.YPS2055 E.YPS2055 M.YPS2055 L.YPS2066 E.YPS2066 M.YPS2066 L.YPS2067 E.YPS2067 M.YPS2067 YPS3137 YPS3060 YPS3395 YPS2073 YPS2060 YPS183 YPS2066 YPS2055 YPS2079 YPS2067 YPS2073 YP...

Ngày tải lên: 09/08/2014, 22:23

... carry- ing a temperature-sensitive mutation in the meiotic inhibitor Pat1p [16,17]. We arrested cells in G1 by removing the nitro- gen source from the medium and induced meiosis by shifting the ... done in duplicate (independent biological repeats including a dye swap). The RNA from the Mei4p overexpres- sion experiment was hybridized in duplicate (technical repeat, includ...

Ngày tải lên: 14/08/2014, 08:20

... probe marked in millimiter increments. Bleeding on probing was recorded and the presence of plaque was registred mesially, buccally, distally, and lingually. Data were obtained at baseline before ... regenerative therapy as a coadjuvant of autologous bone grafting. In contact with the patient's blood or saline solution, the Hyaloss® matrix forms a gel almost instantly, th...

Ngày tải lên: 03/11/2012, 11:35

... [14]. In vertebrates the (2–5)A pathway is also induced by interferons [15]. The major enzyme in this pathway, the (2–5)A synthetase catalyzes the synthesis of a series of 2¢)5¢- linked oligoadenylates, ... root the tree. The anthocyanidin synthase is known to be involved in the catalysis o f the colorless leucoanthocyanidins to the colored anthocyanidins [56]. The p...

Ngày tải lên: 21/02/2014, 15:20

... despite there being no evidence of greater disease activity in terms of clinical scores (skin or joint) or inflammatory markers. Interestingly, the MRI bone oedema score was also higher in the AM ... erosions in PsA (the zoledronic acid in psoriatic arthritis or ZAPA study), but results presented here pertain only to baseline findings in these patients, before administration of...

Ngày tải lên: 09/08/2014, 01:22