Báo cáo y học: "Phylogenetic simulation of promoter evolution: estimation and modeling of binding site turnover events and assessment of their impact on alignment tools" ppsx

... 10, Article R225 Research Phylogenetic simulation of promoter evolution: estimation and modeling of binding site turnover events and assessment of their impact on alignment tools Weichun Huang *† , ... exception of YY1E2F, a composite of YY1 and E2F and chosen on purpose for this study, the TFBS sites used here were arbitrarily selected among th...

Ngày tải lên: 14/08/2014, 08:20

... A.B. (1998) Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J. Neurosci. 18, 7 962–7971. 9. Date, Y. , Mondal, M.S., ... neuropeptides, NPY and orexins, are involved in the regulation of food intake. Sensitivity of orexin A binding to NPY has been described earlier by studying 125 I-labelled orexin...

Ngày tải lên: 08/03/2014, 22:20

... testing. Discussion The present study showed an association between certain promoter genotypes of IL-6 and the more severe outcomes of DIP OA, namely symmetrical and symptomatic DIP OA. IL-6 is one of the ... the reports, a common guanine/cytosine polymorphism at position -174 in the promoter region of the IL-6 gene seems to have a role in a variety of diseases and conditi...

Ngày tải lên: 09/08/2014, 10:23

... assessment of gap region accuracy were typically performed on simulated data only (for example, [40]). Using simulation, Löytynoja and Gold- man, the authors of Prank, have recently argued that other alignment ... (iii) What is the impact of align- ment uncertainty on tree inference? Phylogeny-based tests of alignment accuracy The principle of the phylogeny-based test...

Ngày tải lên: 09/08/2014, 20:21

... M, Koonin EV: Analysis of rare genomic changes does not support the unikont-bikont phylogeny and suggests cyanobacterial symbiosis as the point of primary radiation of eukaryotes. Genome Biol ... exceed- ingly unlikely that any synteny can still be detected. Another approach to the detection of large-scale dupli- cation is to analyze the rate of synonymous base sub- stitutions (dS...

Ngày tải lên: 09/08/2014, 20:21

... recovery and confirmation Seventy four viruses obtained from symptomatic patients were isolated in mosquito cell culture and sub- sequently identified as DENV-1 serotype by monoclonal antibodies and ... Investigations. Transactions of the Royal Society of Tropical Medicine and Hygiene 1984, 78:239-241. 9. Trent DW, Grant JA, Monath TP, Manske CL, Corina M, Fox GE: Genetic variatio...

Ngày tải lên: 12/08/2014, 01:21

... 2 Phylogenetic relationships of the VP1 coding region of type O East African viruses in comparison to other FMD virus serotypes. Evolutionary relationships of the VP1 coding region of FMD type ... coding region of serotype O FMD viruses from Kenya and Uganda has been undertaken to infer evolutionary relationships and processes responsible for the generation and maintenance of...

Ngày tải lên: 12/08/2014, 04:20

... first 249 days of infection. The plasma viral load for P1 was consistently lower than P2 after day 96, with the exception of a sec- ondpeakreadinginP1takenonday249,afterthe detection of HIV-1 super-infection ... for random transmission of genetic variability [9]. If transmission of viral variability is not random, then transmission may occur by natural selection [17,18]. However, tr...

Ngày tải lên: 13/08/2014, 01:21

... Understanding and Control of Life's Function via Systems Biology), and in part by a grant from New Energy and Industrial Technology Devel- opment and Organization (NEDO) of the Ministry of Economy, ... upon exposure to medications and foods that cause hemolysis. Computer simulations for analyzing this deficiency have been reported [17-19], but these simulation models co...

Ngày tải lên: 13/08/2014, 22:22

... question of what type of data would be most useful and how simulation modeling can suggest avenues of experimental investigation. Embryogenesis is a period of profound growth. We believe that one of ... Children's Hospital of New York-Presbyterian and Department of Surgery, College of Physicians and Surgeons, Columbia University, 3959 Broadway, 216B, New York,...

Ngày tải lên: 13/08/2014, 23:20