Báo cáo y học: " Gene expression profiling of Hfe-/- liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers" pdf

... control of hepcidin expression [23], in the B6 strain. Finally, and worthy of note within the context of modifiers of iron loading severity, wild- type D2 mice have significantly lower expression of ... Hfe- deficient B6 and D2 mice (two inbred mouse strains with divergent iron loading severity in response to Hfe disruption), to clarify the mechanisms o...

Ngày tải lên: 14/08/2014, 08:20

... genes by flow cytometry and immunocytochemistryFigure 4 Validation of selected genes by flow cytometry and immunocytochemistry. (a) Flow cytometry analysis of prostate cancer cells co-stained with ... University of York, Heslington, York YO10 5DD, UK. § York Centre for Complex Systems Analysis, Department of Biology, University of York, York YO10 5YW, UK. ¶ Department of...

Ngày tải lên: 14/08/2014, 08:21

... article Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation Vyacheslav A Adarichev 1 , Csaba Vermes 1 , Anita Hanyecz 1 , Katalin ... extremely complex owing to the diversity of cell types involved in the pathology and the polygenic character of the autoimmune disease [1- 5]. The overall picture of molec...

Ngày tải lên: 09/08/2014, 06:22

... pH 7.0 and embedded in paraffin for histological and immunohisto- chemical analyses. Serial histological sections were stained with hematoxylin and eosin and analyzed by two observers (CG and IT) ... expression of 1,058 genes in a subset of four patients with positive syno- vial immunostaining for TNF-α. These genes were enriched in families of genes involved in...

Ngày tải lên: 09/08/2014, 14:20

... effects of iloprost in systemic sclerosis are only partially known. We aimed at studying the gene expression profile of circulating endothelial cells and the effects of iloprost infusion and gene expression ... lies in the high intra-assay reproducibility and the high precision in the detection of both CECs and EPCs due to the gating strategy and to the pre...

Ngày tải lên: 12/08/2014, 14:22

... stains and confirmed by immunohistochemical staining look- ing for pan-cytokeratin, cytokeratin 5 and 7, chrom- ogranin A, synaptophysin and tissue-transcripion-factor- 1. For validation of the ... for progression of cell cycle, the cyclines A2 and B2, cyclin- dependent kinase 4 and the cell division cycle 2 genes were upregulated. In the group of genes involved in DNA rep...

Ngày tải lên: 18/06/2014, 15:20

... women entered in a prospective randomised trial of bre ast radiotherapy fractionation. Gene expression profiling of primary skin fibroblasts exposed in vitro to bleomycin sulphate and mock treated ... performing the Affymetrix Gene Arrays and for technical support and advice and Henrik Edgren at Institute for Molecular Medicine, University of Helsinki, Finland for...

Ngày tải lên: 09/08/2014, 09:20

... Functional annotation of these transcripts provides insights into expression patterns of genes involved in various metabolic and regulatory pathways and into the roles of novel genes with unknown functions. ... seen in the similar expression profiles of the NS, AA, and UA libraries, and the repr ogramming of diatom photosynthesis in response to iron limit a...

Ngày tải lên: 09/08/2014, 20:22

... TGFβ- responsive genes included potential key candidates in the regulation by TGFβ of lung tissue fibrosis and included angiotensin II receptor type 1 (AGTR1), SMURF2, a gene involved in terminating TGFβ ... transcription and signalling, identifying a series of genes previously unknown to respond to TGFβ in lung fibroblasts. These included angiotensin II receptor 1, prov...

Ngày tải lên: 12/08/2014, 18:21

... extensively in viral infection [27] and can induce the gene expressions of interferon and cytokine [28]. Interestingly, an over- expression of IRF-7 can trigger monocyte differentiation towards ... 99:8921-8926. 18. Tomita K, Chikumi H, Tokuyasu H, Yajima H, Hitsuda Y, Matsumoto Y, Sasaki T: Functional assay of NF-kappaB translocation into nuclei by laser scanning cytometry:...

Ngày tải lên: 12/08/2014, 18:22