Báo cáo y học: "Harnessing naturally randomized transcription to infer regulatory relationships among genes" pptx

... the topology of the yeast transcriptional regulatory network.</p> Abstract We develop an approach utilizing randomized genotypes to rigorously infer causal regulatory relationships among ... randomized genotypes to rigorously infer causal regulatory relationships among genes at the transcriptional level. The approach is applied to an experiment in yeast, yiel...

Ngày tải lên: 14/08/2014, 08:20

... gametophyte (pollen) development is dominated by the activity of MIKC*-group genes (blue) and the development of the female gametophyte (embryo sac), embryo and seed is mainly controlled by type ... (pink). Flower Sporophyte Seed Ovule with female gametophyte Pollen (male gametophyte) Sporophyte generation Gametophyte generation Embryo f e Gramzow and Theissen Genome Biology 2010, 11:214 h...

Ngày tải lên: 09/08/2014, 20:22

... Only one study [5] has used accelerometry to examine the contribution of structured physical activity programs to total daily physical activity. Wickel and Eisenmann [5] found that among 6- to ... activity on program days to physical activity on non-program days. For this analysis, only weekdays with eight or more hours of monitoring time were included. Because the first day and las...

Ngày tải lên: 14/08/2014, 08:20

... L-threonine to L-2- aminoacetate (threonine2) ↓ Degradation of dGMP to deoxyguanosine (dgn2) ↓ Degradation of L-lysine to crotonyl- CoA (lysine3) ↓ Degradation of tryptophane to 6- hydroxymelatonin ... randomly picked pathways, all pathways, and pathways highly ranked in pathway selection. We are not able to associate (signifi- cantly) relevant pathways with any of these types of p...

Ngày tải lên: 14/08/2014, 21:20

... carry one or two putative glycans. Seven appear to be nonglycosylated. Therefore, the high number of glycans found in HRP C, E and A types is unusual among class III peroxidases. Since glycans ... likely to start with a pyrrolidone carboxylyl residue (Z) formed from glutamyl (Q). This has been shown experimentally for HRPC, HRPE5 [50] (similar to AtP34 and AtPEa), HRPA2 (similar to...

Ngày tải lên: 21/02/2014, 01:21

... gene, which chelates heavy metals in fibroblast cells [29]. In this study, we used mutational analysis to show that MREa ()434 to )438) is the key transcriptional regulatory element of the WD gene. ... possesses transcriptional regulatory activity and that a variety of nuclear transcription factors interact specifically with MREa [11,33,38,39]. These findings suggest that transcrip- ti...

Ngày tải lên: 17/03/2014, 23:20

... MODIFYING ENZYMES AND THE REPRESSION OF TRANSCRIPTION BY NRs Histone deacetylases (HDACs) Many class II NRs, including thyroid hormone receptor and retinoic acid receptor, have the capacity to ... histone acetyltransferase; histone deacetylase; histone kinase; histone methyltransferase; nuclear receptor; transcription. INTRODUCTION Nuclear receptors (NRs) comprise a large superfamily of...

Ngày tải lên: 31/03/2014, 21:21

... accuracy to fall off rapidly for CSDeconv. Motif occurrence can be used not only to validate binding sites, but potentially also to find them. It may be possible to avoid blind deconvolution by simply ... negligible. Performance To test CSDeconv, we applied it to novel ChIP-seq data for the DosR transcription factor in MTB and to existing data for the GABP transcription fact...

Ngày tải lên: 09/08/2014, 20:21

... an organism’s capacity to generate heritable phenotypic variation, and so increase overall ‘evolvability’. e fluidity of eukaryotic transcriptional regulatory regions may therefore enable the ... Research and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada 2 Department of Molecular Genetics, University of Toronto, Toronto, O...

Ngày tải lên: 09/08/2014, 20:22

... Subjects were free to with- draw from the stu dy at any time, to refuse to answer any question, and to either stop audiotaping or to have audio- tapes of any visit dropped from the study. None of the patient ... this study, there was loss to follow-up among randomized clini- cians before patient recruitment, which led to empty clusters (e.g., clinicians who did not contribut...

Ngày tải lên: 11/08/2014, 05:21