Báo cáo y học: "A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans" pot

... tRNAs,namely of the aspartate-GAU codon as glutamate and the lysine-AAA codon as asparagine, were screened in the massspectrum.Bioinformatics analysis of the genome and proteome The C. albicans ... of the forward-primer 5'-ACTAGACCGCGGGATTATAAAGATGATGATGATAAGAACGACAAATACTCATT-AGC-3', which hybridized with CaPGK1. The reverse primer5'-ATTAGATCGCGATTAGTGATGGTGAT GGTGAT-GGTTTTTGTTGGAAAGAGCAAC-3' ... that most of the alterations and expansions are mediated by structuralchanges in the protein synthesis machinery, in particular in tRNAs, aminoacyl-tRNA synthetases, EFs and terminationfactors...

Báo cáo y học: " Part I, Patient perspective: activating patients to engage their providers in the use of evidencebased medicine: a qualitative evaluation of the VA Project to Implement Diuretics (VAPID)" ppsx

... occurring simultaneously;detailed analysis of the thematic codes; a nd matrix ana-lysis of codes. The first stage was an iterative processwith coding analysis and data collection occurringsimultaneously ... predominatel y whitemale VA patients. The findings may be unique to the VA, as many veterans appear to exhibit a sense of obli-gation that may influence their participation in and per-ception of the interventions. ... patient activation strategies. A semi-structuredapproach was chosen to minimize variation amonginterviewers and to facilitate a systematic means of gath-ering data and conducting analysis of...

Báo cáo y học: " An integrated approach to diagnosis and management of severe haemoptysis in patients admitted to the intensive care unit: a case series from a referral centre" ppsx

... performed in 3 patients(bleeding of 700 ml revealing a cancer complicated by a cardiac arrest; bleeding of 300 ml revealing a cancernearby the pulmonary artery; bleeding of 200 ml compli-cating ... period and may provide a useful frame-work for the therapeutic management of haemoptysis in this clinical setting.To summarize, a multidisciplinary approach remains the cornerstone for the management ... Marie-France Carette - marie-france.carette@tnn.aphp.fr; Bernard Bazelly - bernard.bazelly@tnn.aphp.fr; Jacques Cadranel - jacques.cadranel@tnn.aphp.fr; Charles Mayaud - charles.mayaud@tnn.aphp.fr;...

Báo cáo y học: " Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial" potx

... and acute renal failureamong survivors at day 28, lengths of stay in ICU andhospital, and mortality at days 28 and 60.Anti-coagulant effects of heparinDaily APPT levels were recorded to assess ... Victoria, 3065,Australia.Authors’ contributionsBD and RS participated in the study design, data gathering, interpretation,statistical analysis, and writing the first draft and all revisions of the manuscript. ... grant from the Australian Intensive Care Foundation. The funding body played no role in study design; in collection, analysis, orinterpretation of data; in writing of the manuscript; or in the decision...

Báo cáo y học: "Inhalation with Fucose and Galactose for Treatment of Pseudomonas Aeruginosa in Cystic Fibrosis Patients"

... are surprising. It seems that inhalation alone can clear bacteria from the airways without a strong inflammatory response due to physical elimination of P. aeruginosa via the muco-ciliary ... block P. aeruginosa lectins PA-I and PA-II as an alter-native approach to reduce airway colonisation with this bacteria. P. aeruginosa lectins PA-I and PA-II that bind to fucose and galactose ... aeruginosa INTRODUCTION Chronic infection of the airways with P. aerugi-nosa is the leading cause of morbidity and mortality in the majority of CF patients (1). This pathogen colonises the airways...

Báo cáo y học: "β Treatment with recombinant interferon-β reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis" ppt

... volunteers. J Interferon Cytokine Res 2000, 20:857-866.28. Miyazaki T, Katagiri H, Kanegae Y, Takayanagi H, Sawada Y, Yamamoto A, Pando MP, Asano T, Verma IM, Oda H, NakamuraK, Tanaka S: Reciprocal role ... monocyteactivation. Our data demonstrated statistically significantmodulation of proinflammatory and anti-inflammatory cyto-kine production in animals treated with IFN-β. We found a statistically ... into the mechanism by which IFN-β therapy exerts its beneficial effects, we examinedcytokine expression at the site of inflammation. Severalproinflammatory cytokines play a crucial role in the Available...

Báo cáo y học: "Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren''''s syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate" pptx

... known in SS regarding the molecules acting upstream of the immune-mediatedevents that lead to the amplification of the inflammatorycascade.IL-18, although capable of inducing Th2 cytokines in an ... isolated from salivary glands of patients with SScorrelates with the degree of lymphocytic infiltration in sali-vary gland, a finding that indirectly suggests that the increase in lymphocytic infiltration ... K, Tagawa Y, Iwakura Y, KayagakiN, Kurimoto M, Okamura H, Hada T, Yagita H, Akira S, NakanishiK, Higashino K: IL-18 up-regulates perforin-mediated NK activ-ity without increasing perforin messenger...

Báo cáo y học: "Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis" doc

... As the methotrexate- and deoxyco-formycin-based therapies act as anti-inflammatory agents byincreasing extracellular adenosine and blocking ADA,respectively, the presence of high soluble ADA ... which may beindicated by alterations in DPPIV specific activity [28].Alterations in the DPPIV levels in SF may represent anincrease in the presence of attractin. Certainly, analysis of serum ... effects of NPY in concanavalin A- induced paw edema in rat was potentiated byco-application of a DPPIV inhibitor [80]. The potential to target systemic DPPIV and limit activity in the extracellular...

Báo cáo y học: "Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish wome" pdf

... was classified as having finger OA.Symmetrical OA was defined as a subcategory of OA in atleast two symmetrical pairs of the joints (if two joints of the hand are affected, the same joints of ... haplotypeand hand OA depended on the interaction with dietary calciumintake. A joint effect of a low calcium intake and carriage of the VDR aT haplotype on risk of symmetrical OA exceeded theiradditive ... occupation,age, and all health data of the subjects.Each distal interphalangeal (DIP) joint, proximal interphalan-geal (PIP) joint, thumb interphalangeal joint, and metacar-pophalangeal (MCP)...

Báo cáo y học: " TGF β-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7" pps

... favoring the catabolic side is very likely involved in the pathological fea-tures of OA.Currently, many attempts are being made to repair the carti-lage that has been damaged in OA. One approach ... 6).These data clearly indicate that PG synthesis can be stimu-lated while inhibiting an increase of synovial fibrosis in anexperimental model of OA.Discussion The cartilage damage in OA is ... tookadvantage of the fact that adenoviruses transfect only the syn-ovial lining. In addition, we profited from the fact that Smad7 isan intercellular inhibitor of TGF-β. Smad7 stays inside the...

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