Báo cáo y học: "Tipping the balance in autoimmune disease" doc
Báo cáo y học: "Tipping the balance in autoimmune disease" doc
... ascending paralysis, whereas the other
strain had atypical EAE. The current emphasis of these
studies is on understanding the pattern of trafficking of
these T cells into the central nervous system, ... tip the balance.
Another indication from these results is that immune stimuli
are implicated in the initiation of autoimmune diseases,
supporting the hypothesis that infect...
Báo cáo y học: " Filling the gaps in the genomic landscape" doc
... in- depth sampling of the Actinobacteria. By
analyzing 56 of the newly sequenced genomes the
authors demonstrate improvements in the rate of novel
protein discovery and extend the diversity ... present in all three
strains, leaving the majority of the genes to have either been
gained through gene transfers and internal duplication, or
lost along the evolutionary pat...
Báo cáo y học: "Supply-demand balance in outward-directed networks and Kleiber''''s law" pot
... on all links
Σ
I
xy
, termed total network current, by F,
which is shown to be defined by the equation
F =
Σ
B
y
L
y
. (1)
The initial ODN theory is completed by the introduction
of the relation:
F ... values of u
y
is
ν
y
u
y
. Therefore,
E(d
x
) = (
Σν
y
u
y
)/n
which is equivalent to
E(d
y
) = E(
ν
y
)E(u
y
) + Covariance(
ν
y
, u
y
)
In computing E(
ν...
Báo cáo y học: "Connecting the dots in Huntington’s disease with protein interaction networks" pptx
... began by screening a fetal brain library
using the yeast two-hybrid method and identified new inter-
acting proteins using a total of 52 baits. These baits included
proteins involved in cellular ... standard screening method whereby many strains
containing distinct bait and prey proteins are arrayed and
brought together by mating, such that all pairwise interactions
in a group of protei...
Báo cáo y học: "Distinct synovial immunopathology in Behçet disease and psoriatic arthritis" pot
... similar in the intimal lining layer as well as the
synovial sublining of BD and PsA, indicating that there is no
systematic bias in local inflammation between the two study
groups (Figure 1). Further ... included but minimizes the risk of
systematic biases and false-positive findings.
In the analysis of the infiltrating leukocytes from the innate
immune system, a first str...
Báo cáo y học: "Gene expression signatures for autoimmune disease in peripheral blood mononuclear cells" potx
... While early studies using this approach
were largely in oncology, many new reports are emerging in other fields including infectious diseases
and pharmacology, and applications in autoimmunity have ... activity as measured by the
SLEDAI, reinforcing the hypothesis that the IFN signature
is a measure of disease activity or severity [16].
Inspection of gene expression data generated...
Báo cáo y học: "Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus" pptx
... genotyping. The search
led to the pinning down of a single polymorphism
disrupting the RUNX1-binding site within the organic
cation transporter gene SLC22A4 [5]. Furthermore, and
providing a ... region previously
identified by linkage in sibling pairs, and by thorough
haplotype analysis narrowed it down to a single
polymorphism (having excluded the remaining nine that
showed assoc...
Báo cáo y học: "Mesenchymal stem cells in arthritic disease" pot
... cardiac injuries, at least partially by shifting the
microenvironment at the injury sites from proinflammatory to
anti-inflammatory [55-57]. In a murine pulmonary fibrosis
model, MSCs inhibited ... via either adenoviral infection or
osmotic pumps in inhibiting bleomycin-induced increases in
TNF-α, IL-1α, and trafficking of lymphocytes and neutrophils
into the lung [56]. These succ...
Báo cáo y học: " Mesenchymal stem cells in autoimmune diseases: hype or hope" ppt
... MSCs remain a critical and
unresolved question. By comparing side by side the
eff ects of MSCs in vitro and in vivo, the study by
Schurgers and colleagues brings fresh encouragement to
the endeavors ... remain critical concerning the use of MSCs for
the treatment of human autoimmune disease. It is likely
that the endeavors will eventually pay off , but more
experience wit...
Báo cáo y học: "Predictors of outcome in myxoedema coma" doc
... is interesting epidemiologically and again
highlights the importance of education. Nevertheless, this
information is not useful in determining the outcome once the
patients have reached the intensive ... care setting, unlike the
SOFA (Sepsis-related Organ Failure Assessment) score,
which provides a more dynamic approach in predicting out-
come by regularly analysing six systems,...
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