Báo cáo y học: "Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression" pptx

... properly cited. Effects of tobacco smoke on gene expression<p>Oligonucleotide microarray analysis revealed 175 genes that are differentially expressed in large airway epithelial cells of people ... number of common bronchial airway pathways. The accu- racy of a biomarker of tobacco smoke exposure using irrevers- ible genes in additional samples suggests t...

Ngày tải lên: 14/08/2014, 08:20

... self-antigens with polyclonal activation of B lymphocytes, production of different auto-antibodies, and an altered function of T cells [2-4]. In addition, several abnormalities of B lymphocytes, including ... activation and differentiation of B cells, and the production of high affinity auto-antibodies [5,7]. Thus, it is very likely that the hyperactivity of B cells and...

Ngày tải lên: 09/08/2014, 08:22

... the hypnotic effects of melatonin that are considered an integral component of its physiological role in sleep modulation [20,21]. Administration of mela- tonin facilitates sleep onset and improves ... memory and concentration, and pervasive malaise affecting many aspects of daytime functioning [13]. In a recent study, 32% of night-shift workers reported symptoms of insomn...

Ngày tải lên: 10/08/2014, 09:20

... limitation of this study. Other limitations include the lack of data on changes in dietary habits; physical activity and body composition that could h elp us better understand the effects of CPAP on ... USA. 4 Department of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA. Authors’ con...

Ngày tải lên: 12/08/2014, 13:22

... cis-conformation, which presented the nitro- gen-bond hydrogen and the carbonylic oxygen on the same side of the molecule (usually amide groups are in a trans-conformation, with the nitrogen-bond ... contributed to molecular modeling and data analysis. SV, DR, and LA conducted synthesis and development of the HDACi. LA conducted the HDAC inhibitory assays. ATP and EG contribut...

Ngày tải lên: 12/08/2014, 23:21

... study data and takes responsi- bility for the integrity of the data and the accuracy of the data analysis. He helped conceive of the study and participated in its design and coordination and ... lesions). Extracted mRNAs were used for large-scale gene- expression profiling. The different gene- expression combinations identified by comparison of profiles of early, LS RA...

Ngày tải lên: 09/08/2014, 14:22

... drawback of studying the effects of actual smoke exposure is likely the effect of already devel- oped lesions in the lungs on the response to smoke [43]. In order to understand the mechanism of initiation ... immediately and processed for analysis. Isolation of broncho-alveolar lavage fluid (BALF) After deprivation of vitamin C for 7 days followed by CS exposure for...

Ngày tải lên: 11/08/2014, 08:22

... positive; VB, viable bait only; VBP, viable bait/prey; VP, viable prey only; Y2 H, yeast two-hybrid. Authors' contributions TC, RG and WH conceived and designed the investigations described in this ... that they only used reproducibility as a criterion for validation without considering reciprocity. Consequently, almost half of the reciprocated interactions Two-sided binomial test...

Ngày tải lên: 14/08/2014, 08:20

... expression profiles of meniscal fibrochondrocytesAggrecan gene expression profiles of meniscal fibrochondrocytes. The x-axis refers to the passage number, and the y- axis to the gene expression abundance ... expression profiles of meniscal fibrochondrocytesCollagen II gene expression profiles of meniscal fibrochondrocytes. The x-axis refers to the passage number, and the...

Ngày tải lên: 09/08/2014, 10:21

... CES-D score. Assays Urinary concentrations of 6-sulphatoxymelatonin (aMT6s), the primary metabolite of melatonin, were assayed with a highly specific RIA assay developed by Aldous and Arendt (ALPCO, ... phase-shifting effects. Introduction Older adults have an altered synchronization of circadian rhythms compared to young adults [1-4]. Circadian mis- alignment of rhythms or malsyn...

Ngày tải lên: 10/08/2014, 09:20