Báo cáo y học: "Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression" pptx

... properly cited. Effects of tobacco smoke on gene expression<p>Oligonucleotide microarray analysis revealed 175 genes that are differentially expressed in large airway epithelial cells of people ... number of common bronchial airway pathways. The accu-racy of a biomarker of tobacco smoke exposure using irrevers-ible genes in additional samples suggests that theirreversibility of these gene ... adaptive responseto tobacco exposure and the detoxification of tobacco smoke components. The cytochrome p450s, CYP1A1 and CYP1B1, forexample, are among the rapidly reversible genes and areinvolved...

Báo cáo y học: "Clinical and immunological effects of Rituximab in patients with lupus nephritis refractory to conventional therapy: a pilot study" doc

... self-antigens withpolyclonal activation of B lymphocytes, production of differentauto-antibodies, and an altered function of T cells [2-4]. Inaddition, several abnormalities of B lymphocytes, including ... activation and differentiation of Bcells, and the production of high affinity auto-antibodies [5,7].Thus, it is very likely that the hyperactivity of B cells and auto-antibody production in SLE ... thy-mus as natural regulatory cells and exert their activity by cell-to-cell contact as well as by inducing the differentiation of CD4+CD25- lymphocytes into regulatory cells [6,10,11]. On the...

Báo cáo y học: " Efficacy and hypnotic effects of melatonin in shift-work nurses: double-blind, placebo-controlled crossover trial" ppt

... the hypnotic effects of melatonin that areconsidered an integral component of its physiological rolein sleep modulation [20,21]. Administration of mela-tonin facilitates sleep onset and improves ... memory and concentration, and pervasivemalaise affecting many aspects of daytime functioning[13]. In a recent study, 32% of night-shift workersreported symptoms of insomnia or excessive daytimesleepiness, ... interests.Authors' contributionsKHS helped with the conception and design of the study,helped to supervise the staff and helped to draft the man-uscript. OA and GHP helped with the conception and design of...

Báo cáo y học: " Weight and metabolic effects of cpap in obstructive sleep apnea patients with obesity" pot

... limitation of this study. Other limitations include the lack of data on changes in dietary habits; physical activity and bodycomposition that could h elp us better understand the effects of CPAP on ... USA.4Department of Medicine,Section of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.Authors’ contributionsJMG and AS participated ... along with an assessment of dietary habits; physical activity, energy expenditure,anthropometrics (i.e. waist-to-hip ratio) and body com-position in order to better understand the effects of CPAP...

Báo cáo y học: ""Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence" doc

... cis-conformation, which presented the nitro-gen-bond hydrogen and the carbonylic oxygen on thesame side of the molecule (usually amide groups are in atrans-conformation, with the nitrogen-bond ... contributed to molecular modeling and data analysis. SV, DR, and LA conducted synthesis and development of the HDACi. LA conducted the HDACinhibitory assays. ATP and EG contributed the idea of using ... because of the intrinsi-cally slow mode of action of epigenetic modulators,which only indirectly induce HIV-1 activation. This wasconfirmed by our experiments using Jurkat cell cloneswith...

Báo cáo y học: "Early and long-standing rheumatoid arthritis: distinct molecular signatures identified by gene-expression profiling in synovia" pot

... study data and takes responsi-bility for the integrity of the data and the accuracy of the dataanalysis. He helped conceive of the study and participated inits design and coordination and ... lesions). ExtractedmRNAs were used for large-scale gene- expression profiling.The different gene- expression combinations identified bycomparison of profiles of early, LS RA and healthy synovia ... its design and coordination and helped analyze and interpret biological data and draft the manuscript. XLLhelped conceive of the study and participated in its design and coordination and helped...

Báo cáo y học: " Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin c" ppsx

... drawback of studying the effects of actual smoke exposure is likely the effect of already devel-oped lesions in the lungs on the response to smoke [43].In order to understand the mechanism of initiation ... immediately and processed for analysis.Isolation of broncho-alveolar lavage fluid (BALF)After deprivation of vitamin C for 7 days followed by CS exposure for 14 days with supplementation of 1 mg ... evidenced by immunoblottingOxidation of lung proteins was evidenced by immunob-lotting of the dinitrophenylhydrazone derivatives of pro-tein carbonyls followed by densitometric evaluation of the...

Báo cáo y học: "Coverage and error models of protein-protein interaction data by directed graph analysis" pptx

... positive; VB,viable bait only; VBP, viable bait/prey; VP, viable prey only; Y2 H, yeast two-hybrid.Authors' contributionsTC, RG and WH conceived and designed the investigationsdescribed in this ... that they only used reproducibility as acriterion for validation without considering reciprocity.Consequently, almost half of the reciprocated interactionsTwo-sided binomial test on the data ... tested, but only found once, whereas the other one has only been uni-directionally tested and found.SSA1PHO3TEF2RPC82CProportions of proteins sampled across datasetsFigure 2Proportions of proteins...

Báo cáo y học: "Passage and reversal effects on gene expression of bovine meniscal fibrochondrocytes" pdf

... expression profiles of meniscal fibrochondrocytesAggrecan gene expression profiles of meniscal fibrochondrocytes. The x-axis refers to the passage number, and the y- axis to the gene expression abundance ... expression profiles of meniscal fibrochondrocytesCollagen II gene expression profiles of meniscal fibrochondrocytes. The x-axis refers to the passage number, and the y- axis to the gene expression ... chondrocytes in morphology and to upregulateFigure 2Collagen I gene expression profiles of meniscal fibrochondrocytesCollagen I gene expression profiles of meniscal fibrochondrocytes. The x-axis refers...

Báo cáo y học: "Circadian phase-shifting effects of a laboratory environment: a clinical trial with bright and dim light" ppsx

... CES-D score.AssaysUrinary concentrations of 6-sulphatoxymelatonin(aMT6s), the primary metabolite of melatonin, wereassayed with a highly specific RIA assay developed byAldous and Arendt (ALPCO, ... phase-shifting effects. IntroductionOlder adults have an altered synchronization of circadianrhythms compared to young adults [1-4]. Circadian mis-alignment of rhythms or malsynchronization might con-tribute ... MD, and Anthony C. Cress assisted with this study. The study was performed in Dr. Kripke's lab-oratory in the Department of Psychiatry and Sam and Rose Stein Institute for Research on...

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