Báo cáo y học: "dentification of novel regulatory factor X (RFX) target genes by" docx

... motifs that cover X- boxes of the entire set of known target genes at the time (see Materials and methods). Four (RYYVYY N1-3 RRHRAC, GYTNYY N1-3 RRNRAC, GYTDYY N1-3 RRNRAC, GYTRYY N1-3 RRHRAC) were searched ... pseudoobscura No. of X- box No. of X- box Strand Strand Conserved blocks around X- box † Gene ID + - Gene ID + - No. of conserved X- box* X- box Dist. X- box Dist...

Ngày tải lên: 14/08/2014, 08:20

... hypotheses testing with the false discovery rate method (q-value) [76]. 7 very highly expressed during cell cycle progression (201) 18 widely expressed + very highly expressed during cell cycle ... very highly expressed during cell cycle progression (15) 51 constitutively expressed (54) 64 constitutively expressed (17) 3 widely expressed, not in roots, not stress-responsive (516) 9 expression...

Ngày tải lên: 14/08/2014, 17:22

... & Technology, Yemen. The authors would like to thank Prof Dana Pe'er, Columbia University; Dr Kevien Yip, Yale University and Prof G. Stolovitzky, IBM Computational Biology Center for ... Generally, comparing different biclustering algorithms is not straightforward as they differ in strategy, approach, time complexity, number of parameters and predictive capacity. They are st...

Ngày tải lên: 13/08/2014, 16:20

... binding intact factor X and Gla– EGF N (data not shown). Kinetics of membrane binding The kinetics of binding to PL membranes of the zymogen factor X, activated factor X (factor Xa) and the active ... factor IX phospholipid-binding site is required for calcium-dependent acti- vation of factor IX by factor XIa. J. Biol. Chem. 262, 7605–7612. 30. Nelsestuen, G.L. (1876...

Ngày tải lên: 08/03/2014, 23:20

... understanding of the complex interplay of growth factors, cytokines, and enzymes in the IVD. To our knowledge, this is the first study that demonstrates the pathophysiologic effects of FGF2 in spine ... of the IVD. An upregulation of anabolic factors coupled with a downregulation of catabolic factors may poten- tially induce cartilage regeneration. In cartilage, FGF2 is produced b...

Ngày tải lên: 09/08/2014, 10:23

... methyl ester had only a minor effect on the toxicity of the protein. Addition of microglia had no signifi- cant effect on the toxicity of PrP121– 231. These results suggest that the toxicity of ... mice lacking expression of the full length PrP c is neurotoxic. This neuro- toxicity does not require expression of PrP c . The neuro- toxicity can be inhibited by the presence of the...

Ngày tải lên: 31/03/2014, 23:20

... isolation, and microarray analysis using the Affymetrix GeneChip technology (Affymetrix, Santa Clara, CA, USA). We identified a large number of genes that were differentially expressed between blood ... our understanding of human pathogenesis. For example, profiling gene expression in a rat model of inflamma- tion using SAGE (serial analysis of gene expression) has pro- vided novel...

Ngày tải lên: 09/08/2014, 07:20

... what extent the pregnancy history (parity) affects the incidence of CIA later in life has, to our knowledge, not previously been studied. Importantly, RA occurs predomi- nantly in women, many of ... the possibility of detecting new polymorphic genes of importance in this disease. The first conclusion from the present paper is that multiparity does not negatively influence the incide...

Ngày tải lên: 09/08/2014, 07:20

... manuscript. YX helped to carry out the immu- noassays. HN, K Masuko, KY, K Noyori, K Nishioka, and TS participated in the design of the study and performed the sta- tistical analysis. TK conceived of ... revealed by comparison of the three panels of Fig- ure 1c–e. Specifically, we recovered peptides from the 30 protein spots after in-gel digestion by trypsin, then measured masses of...

Ngày tải lên: 09/08/2014, 08:23

... responses [32,33]. Besides control of gene expression, protein synthe- sis, and secretion, the biological activity of cytokines and growth factors is regulated by binding to ECM proteins such as ... biosynthesis and can be further modified on cell surface-associated and extracellular HSPGs by a novel class of extracellular sulfatases which includes two enzymes, Sulf-1 and Sulf-2. Prev...

Ngày tải lên: 09/08/2014, 10:23