Báo cáo y học: "Functional constraint and small insertions and deletions in the ENCODE regions of the human genome" ppsx
Báo cáo y học: "Functional constraint and small insertions and deletions in the ENCODE regions of the human genome" ppsx
... discrete regions that encompass 30 mega-bases, or about 1% of the human genome, with 14 of these regions (about 15 megabases) selected manually and the remainder randomly [11]. Small indels in the ENCODE regions ... in the human genome. A minority of insertions and deletions may also have plausibly played a major role in spe-ciation events, including human- chimpanzee phenotypic dif-ferences [9,10]. An investigation ... features and evolutionary constrained sequence?Here we describe the distribution of small indels (rangingfrom 1 to 20 base pairs [bp]) in the manually and randomlyselected ENCODE regions, their...
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Báo cáo y học: "Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer" pdf
... of proteins including cyclins B1 and E1 as well as components of the protein synthesis machinery including phosphory-lated S6 ribosomal protein and 4EBP1, a group with overexpression of stromal ... from the training set. 3A. Probability of recurrence as a continuous function of the score. The rug plot shows the prognosis score for individual patients in the study. Dashed curves indicate the ... receptors and proliferation markers involved in therapy resistance (EGFR, CCNB1, CCNE1) arepart of the 10-protein panel. The combination of 10 markers and the power of the 10markersascomparedtoER/PRandHER2isnovel.TheER,PRandHER2andtheproliferation...
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Báo cáo y học: "Functional impairment related to painful physical symptoms in patients with generalized anxiety disorder with or without comorbid major depressive disorder: post hoc analysis of a crosssectional study" docx
... anxiety, especially if the symp-toms are multiple and medically unexplained [42]. In the light of the study findings, primary care physi-cians should seek for an effective management of thesePPS, ... back pain, shoulder pain, pain interferencewith daily activities, and time experiencing pain whileawake [25]. The VAS overall pain severity score of >30considered as the cutoff point in the ... func-tional impairment. The current study contributes to the understand ing of the specific role of such pain symptoms in worsening the functioning in patients with GAD. The presence of PPS is associated...
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Báo cáo y học: " Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered" pptx
... proteolysis in cultured L6myotubes. Shock 1998, 10:298-306.39. Yin HN, Chai JK, Yu YM, Shen CA, Wu YQ, Yao YM, et al: Regulation of signaling pathways downstream of IGF-I/insulin by androgen in ... are among the most widely used drugs in the world and are effective in the treatment of manyinflammatory and immune diseases. However, one of the main side-effects of systemically administered ... an increase in muscle mass probably mediated by inhibition of muscleproteolysis rather than by stimulation of muscle proteinsynthesis [27]. Inhibition of muscle proteolysis, in parti-cular the...
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Báo cáo y học: "Systematic review: Intra-aortic balloon counterpulsation pump therapy: a critical appraisal of the evidence for patients with acute myocardial infarction" doc
... appraisal of randomized clinical trials of IABP therapy in AMI patientsThorough critical appraisal involves determining the validity of the study design, understanding the results and decidingwhether ... besystemically heparinized. IABP therapy does not prohibit the use of other medications often used in AMI patients,including aspirin, systemic heparinization, angiotensin-con-verting enzyme inhibitors, ... werehemodynamic instability necessitating the use of an IABP,cardiogenic shock, bleeding diathesis prohibiting the use of aspirin or heparin, precatheterization administration of thrombolytic therapy,...
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Báo cáo y học: " Tumour necrosis factor-α stimulates HIV-1 replication in single-cycle infection of human term placental villi " docx
... Tremblay MJ: The low viral production in trophoblastic cells is due to a high endocytic internalization of the human immunodeficiency virus type 1 and can beovercome by the pro-inflammatory cytokines ... soaked in one case with 3 ml of plain histoculturemedium and in the two other wells soaked in 3 ml of histoculture medium containing recombinant human TNF-α (R&D systems, Deutschland) in final ... dose otherwise, by comparing the mean of the corresponding ratios to 1, using the resid-ual error derived from the analysis of variance. The TNF-αdose effect was expressed as the mean of the...
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Báo cáo y học: "Can choices between alternative hip prostheses be evidence based? a review of the economic evaluation literature" ppsx
... years or over.Types of InterventionsAny THR surgery using any type of hip prosthesis(using any surgical technique) compared to THR sur-gery using any other type of prosthesis (any surgicaltechnique).NoseYoNExamines ... manufacturing industry has responded totheincreaseindemandforTHRsurgerybyinvestingsignificant amounts of money in developing new, moredurable, prostheses.Economic evaluation is widely used to inform ... results and writing of the manuscript. MM, KT and AM contributed in editing the manuscript. Allauthors have read and approved the final manuscript.Competing interests The authors declare that they...
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Báo cáo y học: "Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes"
... the reported ethanol-induced expression and activation of cytokines and chemokines in monocytes and macrophages (including Kupffer cells) [41, 42], and ethanol-induced mucosal injury in the ... potential therapeutic approach when considering the reported high expression of the ankyrin-repeat oncoprotein (gankyrin) in human hepatocellular carcinoma . Gankyrin binds to the cell-cycle regulator ... gastrointestinal tract leading to increase in the permeability of the gut mucosa to endotoxins [43, 44]. These factors are involved in ethanol-induced liver damage. Thus, the direct injection of...
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Tài liệu Báo cáo Y học: Functional analysis of a small heat shock/a-crystallin protein from Artemia franciscana docx
... signifi-canceofasmallheatshock/a-crystallin protein (p26) in encystedembryos of the brine s hrimp, Artemia franciscana. Am. Zool. 39,836–847.49. Liang, P. & MacRae, T.H. (1999) The synthesis of a small ... of the C-terminal extension has the potential to perturb function and reduce solubility of these proteins and their complexeswith target proteins [15–19]. The N-terminus, which may bepartly ... proposedfor these proteins [7,8]. The a-crystallin domain, locatedtoward the C-terminus of the protein monomer, consists of 80–100 amino-acid residues and is important for oligomerformation and chaperoning...
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Báo cáo Y học: Functional reconstitution of the HIV receptors CCR5 and CD4 in liposomes pot
... Groningen, the Netherlands) in order to obtain a recombinant proteincontaining the C-myc epitope followed by six histidines at the C-terminus. A plasmid containing the wild type version of CCR5 ... glycosaminoglycans [37].As the myc-his tag of the protein was present at the C-terminus of the receptor which is located on the inside of the cell, we then determined if signal transduction by the ... codon by PCR and expanded in pBSK1 plasmid. The resulting XhoI/ApaI fragment was cloned into the corres-ponding sites in the polylinker region of the pcDNA3.1-myc-His expression vector (Invitrogen,...
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