Báo cáo y học: "Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery" doc

... demonstrated increased synth- eses of the cytoskeletal proteins actin and tubulin after axotomy of the rat facial nerve simultaneously to the enhanced NF contents and a low regulation of NF synthesis. ... the intensity of the FGF-2 immunoreactivity increased slightly in the cytoplasm of neuronal profiles seven days after the axotomy as evaluated qualitatively by...

Ngày tải lên: 10/08/2014, 10:20

... the binding of ligands with primordial proteins would also be a critical step in the origin of life. Thus, it is intriguing to explore the chro- nology of ligand -protein binding and answer the ... significant implications for tracing the important events in the origin of life and as well as for understanding the new paradigms in drug discover...

Ngày tải lên: 14/08/2014, 08:20

... revealed the predominance of two amino acids: alanine (39.2%) and glycine (30%). Interestingly, the proportions are very similar to those found in WSM for alanine and glycine. Curiously, the presence ... Hydroxyproline, hydroxy- lysine and phosphoserine were not detected in WSM, WIM, EDTA-SM and EDTA-IM. The comparison of the amino acid composition of the main...

Ngày tải lên: 21/02/2014, 01:21

... of a variety of inflammatory chemokines and their receptors [5,6]. In vitro studies have suggested that both so-called homeostatic chemokines and inflammatory chemokines, including CC chemokine ... within the inflammatory infiltrates in the joints of the CCR2 –/– mice [19]. Data from the knockout mice suggest that at least some individual inflammatory chemokine receptors...

Ngày tải lên: 09/08/2014, 01:23

... processes underlying RP and PAH contribute to the familiar pattern of skin, renal and gastrointestinal pathology. The emergence of effective and conveniently administered therapy for PAH increases the importance ... at 1 year and 2 years of 96% and 89% compared with Viewpoint Cold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pu...

Ngày tải lên: 09/08/2014, 06:23

... acclimated to the treadmill by gradually increasing the running speed and time as follows: day 1, 10 minutes at 10 m/min; day 2, 15 minutes at 12 m/min; day 3, 20 minutes at 15 m/min; day 4, 30 minutes ... at 18 m/min; and day 5, 35 minutes at 20 m/min. On day 8 and thereafter, the rats were forced to run for 55 minutes a day at 20 m/min, with the first 10 minutes consisting...

Ngày tải lên: 09/08/2014, 10:22

... correlation between MMP activity (evidenced by the 342 FFGVG-G2 and CTX biochemical markers) and the inability of cytokine-treated chondrocytes to initiate and/ or maintain anabolic activity. Switching to anabolic ... generated by an array of MMPs, of which MMP-2 and MMP-9 are only a subset. On other occasions, the presence of these gelatinases has been a valid indicatio...

Ngày tải lên: 09/08/2014, 10:23

... quality control program run by the Korean Society of Laboratory Medicine [3]. In 1999 and 2007, reports of antinuclear antibody test using the IT-1 cell line on 208 and 588 systemic lupus erythematosus ... commercialized and passed inspection by the Korea Food and Drug Administration in South Korea. Currently, IT-1 is being used under the name of the autoimmune t...

Ngày tải lên: 09/08/2014, 14:21

... systematic study is mandatory to compare the sensitivity and specificity of the AIT test for the detection of anti-Rib-P antibodies and other antibody specificities using a variety of contemporary diagnostic ... assay, and then used these sera to determine the positivity and staining patterns in the AIT test. This method raises concerns because it is generally kn...

Ngày tải lên: 09/08/2014, 14:22

... in the thyroid glands. The ability of cancerous thyroid cells to actively transport iodide via NIS has provided a unique and effective delivery system for the detection and destruc- tion of these ... functionally expressed in thyroids, salivary glands, gastric mucosa, and lactating mammary glands [1]. NIS mediates the active transport of iodide into the folli- cula...

Ngày tải lên: 10/08/2014, 05:21