Báo cáo y học: "Quantitative genomics of locomotor behavior in Drosophila melanogast" doc

... in 2003. The lines were inbred by 20 generations of full-sib inbreeding to create 340 inbred lines. Locomotor reactivity for each of the inbred lines was measured by randomly assigning the lines ... locomotor reactivity scores (seconds) of lines containing P-element insertional mutations in candidate genesFigure 5 Mean locomotor reactivity scores (seconds) of lines containin...

Ngày tải lên: 14/08/2014, 08:20

... analyzed the morphology of type I DA neurons in these mutant flies. In most cases, the mutant alleles pro- duced a phenocopy of the RNAi phenotype, validating the accuracy of the approach. Analysis ... functions of each transcription factor group in dendritic patterning of type I DA neurons in the Drosophila peripheral nervous system. Subtypes of DA neurons have simple a...

Ngày tải lên: 14/08/2014, 16:21

... L, r Arrestin 1 36D3 Metarhodopsin binding G-protein coupled receptor protein signaling pathway; deactivation of rhodopsin mediated signaling; endocytosis; intracellular protein transport; ... recombi-nation breakpoint is not determined, and gold if the genotype is unknown because of residual heterozygosity in the RI line. The results of Tukey tests separating the lines into gr...

Ngày tải lên: 14/08/2014, 14:21

... activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892. 7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflam- matory therapy. ... and equally efficacious in man- aging inflammation. However, whereas the selectivity of this group of compounds might allow inflammation to be inhibited with minimal effects on certain h...

Ngày tải lên: 09/08/2014, 01:21

... negatively regulate integration [116,117]. This is seen with both integrating and non- integrating virus, thereby effectively regulating superin- fection at the level of integration rather than entry [117]. ... that seen in productive infec- tion using wild type virus. Thus, the activity of Nef was not linked to integration in regards HLA class I modula- tion, a finding confirmed in...

Ngày tải lên: 13/08/2014, 01:21

... of rhinitis, eosinophilia and expression of several cytokines [2,5]. Materials and methods Nasal biopsy samples were obtained as a part of a pre- viously published clinical study [2]. Briefly, ... primary antibody. Represen- tative pictures were recorded prior to destaining the slides of hematoxylin with 1% HCl in 70% ethanol. The hematoxylin destained samples were assessed in a b...

Ngày tải lên: 08/08/2014, 21:20

... diversification of their glycomes. N-linked glycosylation Protein N-glycosylation, the most prevalent and highly conserved type of protein glycosylation, is initiated in the rough endoplasmic reticulum of ... mucin-type O-glycosylation in animals [62]. Glycophosphorylation o f the hydroxya- mino acids threonine and serine may be less prevalent in D. purpureum owing to the much sma...

Ngày tải lên: 09/08/2014, 22:23

... cells treated with increasing amounts of formaldehyde identified lysine acetylat ion marks on histone H3 lysine 9 a nd lysine 14 (H3K9acK14ac) and histone H4 lysine 12 and lysine 16 (H4K12acK16ac). ... chemical cross-linking needed to trap protein-protein and protein-DNA interactions, while still allowing for the solubility of chromatin for purification and access of affinity reagents [...

Ngày tải lên: 10/08/2014, 09:22

... microscopy technique involving visualisation of protein by SYPRO ruby staining capable of detecting 85 pg of p rotein on a surface area of 1 mm 2 which is significantly lower than the sensitivity of ... reprocessing on podiatry instruments by measurin g residual protein contamination of instruments reprocessed by both methods. Methods: The residual protein of 189 instruments rep...

Ngày tải lên: 10/08/2014, 21:24

... Lehtonen OP, Isolauri E: Importance of intestinal colonisation in the maturation of humoral immunity in early infancy: a prospective follow up study of healthy infants aged 0-6 months. Arch Dis ... deviations in the intestinal microbiota may render us more vulnerable to intestinal inflammatory diseases and to diseases beyond the intestinal environment. Genomic information will be...

Ngày tải lên: 14/08/2014, 14:21