Báo cáo y học: "Reduced selection leads to accelerated gene loss in Shigella" potx

... in purifying selection may lead to other gene loss events that may be adaptive. For example, loss of flagellar genes may occur in Shigella due to a pathway-specific reduc- tion in purifying selection, ... finding that the genes that are lost more readily are those that are less con- strained in the organisms in which they are maintained points towards reduced purifying...

Ngày tải lên: 14/08/2014, 08:20

... detected in the cytoplasm of cells in the HGPIN (high grade PIN) lesions (Figure 3A; arrow-indicated in (c)) and CaP (Figure 3A; arrow- indicated in (d)). Interestingly, P63 was expressed in some ... evidence so far to support this hypothesis. Hedgehog (Hh) signalling plays a key role in stem cell plasticity and in many developmental, physiological, and pathogenetic processes...

Ngày tải lên: 10/08/2014, 05:21

... strongly affected by the inflammatory process and ultimately this interferes with bone mechanical performance. In addition, scanning electron microscopy findings showed that SKG mice exhibit thinner ... the loss of bone organic matrix. It was therefore of interest to use the newly discovered potential of multiphoton microscopy to analyze this issue in more detail. Multiphoton micros...

Ngày tải lên: 12/08/2014, 11:22

... BMP-7 to healthy FLSs in vitro had no effect on α-sma Figure 1 Haematoxylin and eosin staining on healthy and arthritic synovial tissueHaematoxylin and eosin staining on healthy and arthritic synovial ... previously described, staining of human synovial tissue with haematoxylin and eosin showed an increase in the number of cell layers of the synovial lining of RA patients (Figure 1). E-...

Ngày tải lên: 09/08/2014, 08:23

... myopathy occurring after two doses of methylprednisolone. Typically, acute steroid myopathy occurs with therapy using intravenous corticosteroids at high doses. Acute myopathy developing very ... on day 2 of therapy. Initially, he ignored the symptoms, but his condition continued to escalate in a generalized fashion. On day 3 of the rapy, myalgia and muscle weakness progressed to involv...

Ngày tải lên: 11/08/2014, 00:22

... be desirable to pay special attention not only to the typical symptoms of the disease but also to these PPS. Therefore, clinicians may routinely evaluate the extent to which symptoms impact patients’ ... DN: Efficacy of duloxetine in the treatment of generalized anxiety disorder in patients with clinically significant pain symptoms. Depress Anxiety 2008, 25:E1-11. 31. Demyttenaere...

Ngày tải lên: 11/08/2014, 15:22

... airways [12]. Some pulmonary and airway sensory receptors and afferent pathways may be co mmon to both the urge -to- cough and dyspnea [11]. In addition, brain imaging studies showed the brain cortical ... respiratory defense mechanism, blunted cough reflex sensitivity may contribute to the risk of respiratory tract infection in cigarette smokers. More- over, since dyspnea is usually...

Ngày tải lên: 13/08/2014, 10:20

... pathology in the intensive care unit (ICU) increases rates of morbidity and mortality. Intraabdominal pathologies are usually identified through presenting symptoms, clinical signs, and laboratory ... delay diagnosis because of inconclusive laboratory tests or imaging results, or the inability to safely transfer a patient to the radiology room. In the current study we evaluated the sa...

Ngày tải lên: 13/08/2014, 15:21

... only slide 1 contains a self-hybridization. The VSG interaction contains variances due to hybridization and sampling. Some factors are confounded Due to the fact that in our DNA-microarray ... handle a gene factor of 2108 levels (genes) and additional interactions in model (1). To reduce data dimensions, we chose to randomly select genes instead of other methods (e.g. group...

Ngày tải lên: 14/08/2014, 14:21

... successful in the identification of regulatory motifs, phylogenetic footprinting methods still show some shortcomings. To assess these difficulties, most apparent when applying phylogenetic footprinting ... to any set of organisms and genes for which one wants to compare the intergenic sequences. Results A two-step procedure for phylogenetic footprinting In this study, we aimed to...

Ngày tải lên: 14/08/2014, 16:20