Báo cáo y học: "Quantifying the major mechanisms of recent gene duplications in the human and mouse genomes: a novel strategy to estimate gene duplication rates" docx

... 1–6).Intraoperative frozen section of the sentinel nodes identi-fied tumour cells in 23 women with the subsequent for-mal H&E examination confirming the presence of lymphatic metastases in ... 6–22). In two patients the sentinel node(s) were the only involved nodes while the other five women (included two of whomhad only micrometastases evident in their sentinel node)had non -sentinel ... evalu-ation of sentinel lymph nodes in patients with breast can-cer. It allows immediate decision making regarding the need for ALND in the majority of patients.Competing interests The authors...

... since the 13-mer motif occurs in only about 40% of human hotspots [32] and the variation in the zinc finger arrayof the Prdm9 gene can expl ain only about 18% of varia-tion in human recombination ... analysiscould not find any local polymorphisms associated with the variation i n crossover rate in hotspots MSTM1a andMSTM1b on human chromosome 1 [45]. Since the two hotspots are within 2 ... formation.Chowdhury et al. [34] identified six genetic loci asso-ciated with recombination phenotype, including one in the RNF212 gene, and also found differences in sequence polymorphisms associated with...

... isstrongly upregulated around the injury site, possibly playing a role in the regulation of the inflammatory response. In this study we investigated the effect of celecoxib, a COX-2 inhibitor, on functional ... evaluated. Functional recovery was then assessed bycalculating the sciatic functional index (SFI) on days 0,1,7,14 and 21 in all groups, and registering the day of motor and walking onset. In comparison ... and pro-inflammatorycytokines have been implicated in the orchestration of the inflammatory process that lead to degeneration andregeneration after nerve injury [18]. One of thesecytokines,...

... retraction wasmeasured, or the footpad was pinched and the withdrawalresponse was measured. As sensory answer is anotherparameter indicating whether a nerve has regeneratedthrough an artificial ... bridgingmaterials evaluated in rat experiments by means of a systematic review.Materials and methods: A systematic review was conducted, searching MEDLINE, HTS andCENTRAL to identify all trials evaluating ... file[http://www.biomedcentral.com/content/supplementary/1749-7221-4-19-S1.TIFF]Additional file 2studies utilizing artificial nerve grafts in the rat. overview of the vari-ous studies utilizing artificial nerve grafts in the rat and evaluating func-tional outcome.Click...

... play the piano.Our patient had many of the clinical and anatomicfindings typical of OTCS: the dysmorphic face, whitematter alteration, as described by Lalatta [4] and byAzimi [5], cerebral ... Owan I,Kanaya F, Kubota Y, Oike Y, Yamamoto T, Kurosawa K, Fukushima Y, Bohring A, Opitz JM, Yoshiura K, Niikawa N, Naritomi K: Mutations in CD96, a Member of the Immunoglobulin Superfamily, ... syndrome presenting with sudden unexplained death in the operating room: a case report. Journal of Medical Case Reports 2011 5:222.Submit your next manuscript to BioMed Centraland take full advantage of:...

... COX: Cyclooxygenase, LOX: Lipoxygenase, Indo:Indomethacin, PC: Polygonum cuspidatum, PCE: Polygonum cuspidatum extract in 50% ethanolCompeting interests The author(s) declare that they have ... InflammationOpen AccessResearchTopical anti-inflammatory activity of Polygonum cuspidatum extract in the TPA model of mouse ear inflammationEve E Bralley1, Phillip Greenspan1, James L Hargrove*2, ... than on an internal epithe-lium. Therefore, the present study tested whether PCE hastopical anti-inflammatory activities in the well-character-ized TPA- induced mouse ear model of inflammation,edema,...

... not for citation purposes)BMC Plant BiologyOpen AccessResearch article Lutein is needed for efficient chlorophyll triplet quenching in the major LHCII antenna complex of higher plants and effective ... property of quenching harmful 3Chl* by binding at site L1 of the major LHCII complex and of other Lhc proteins of plants, thus preventing ROS formation. Substitution of lutein by violaxanthin decreases ... the most abundant carotenoid in the higher plant photosynthetic apparatus and the only ligand for site L1 in Lhc proteins, whose occupancy is essential for protein folding and the quenching of...

... determining the impact of experimental-induced allergic airway inflam-mation on chemical-induced lung carcinogenesis in mice. We hypothesized that either acute or chronic allergic airway inflammation ... mediator of allergic inflammation of the airways, does not influence chemical lung carcinogenesis induced by a prototype carcinogen.Figure 3 Levels of interleukins (IL)-4, -5, -6, and 13, asdetermined ... carcinogene sis in the lungs of our experimental mice on the Balb/c background. Allergic airway inflammation does not impact chemicallung carcinogenesis We subsequently assessed lung carcinogenesis, ...

... accelerated lung function decline in the general population is a first step in a prevention strategy against the worldwide increasing respiratorypathology of chronic obstructive pulmonary disease ... NMPH, OB,EWR obtained funding. NMPH, CS, OB, EWR areinvolved in SAPALDIA Cohort Study and UAL was the co-principal investigator of the SAPALDIA Cohort Study.SHD, CS, MI, OS did the health data ... Hardy-Weinberg equilibriumIle – isoleucineLHS – Lung Health StudyPCR – polymerase chain reaction SAPALDIA – Study on Air Pollution And Lung Disease In AdultsVal – valineCompeting interestsThe...

... 8, Article R158ResearchQuantifying the major mechanisms of recent gene duplications in the human and mouse genomes: a novel strategy to estimate gene duplication ratesDeng Pan and Liqing ... 8,312 in human and 8,105 in mouse are single-copy genes, and the remaining are clus-tered by Ensembl into 3,538 families in human and 3,600families in mouse. We paired genes within each family and ... obtained the lowerlimits by keeping only the pair that has the smallest Ks amongall of the gene pairs that share the same parental genes. The number of retrogenes in human in this study is approximatelythe...