Báo cáo y học: " Violating the splicing rules: TG dinucleotides function as alternative 3'''''''' splice sites in U2-dependent introns" docx
Báo cáo y học: " Violating the splicing rules: TG dinucleotides function as alternative 3'''' splice sites in U2-dependent introns" docx
... analyzed the conservation of splice sites in homologous introns as an indication of alternative splice variants being under purifying selection. Out of 36 introns with 3' TG splice sites ... guanine nucleotide binding protein gene GNAS is spliced at either TG or AG in the 3' intron sequence CTGCAG [15,16]. Remarkably, the homologous Drosophila gene shows...
Ngày tải lên: 14/08/2014, 08:20
Báo cáo Y học: Monitoring the structural consequences of Phe12 fi D-Phe and Leu15 fi Aib substitution in human/rat corticotropin releasing hormone Implications for design of CRH antagonists pdf
... hormone [38,40]. The changes engineered in the sequence of the peptide, either through the nature of the side chain of the new amino acids or through their non-native conforma- tional features, increase the ... almost typical for the 3 10 helix. In this region of the polypeptide chain, the secondary structure is characterized also by the O i H N i þ 3 hydrogen bonds,...
Ngày tải lên: 17/03/2014, 10:20
Báo cáo Y học: Probing the role of glutamic acid 139 of Anabaena ferredoxin-NADP+ reductase in the interaction with substrates pptx
... strength was the same in all of the FNR forms, showing a decrease in the k cat as the salt concentration was increased. When the FNR NADPH-dependent cytochrome c reductase activity was assayed using ... ionic strengths assayed (within a factor of 1.5). Moreover, in all cases an important decrease in the efficiency of the assay was observed upon increasing the ionic st...
Ngày tải lên: 31/03/2014, 08:20
Báo cáo y học: " Mapping the potential distribution of high artemisinin-yielding Artemisia annua L. (Qinghao) in China with a geographic information system" ppsx
... regions with similarity index (SI) of 99%-100%. County/City, Province* Suitable areas km2 Suitable areas % County/City, Province Suitable areas km2 Suitable areas % Youyang, Chongqing 4386 92 Hefeng, ... Plant Germplasm Resources [33]; (5) field data of wild A. annua L. and interviews in Youyang County in 2008. Due to the excellent quality of A. annua L. from the habitats in Youyan...
Ngày tải lên: 13/08/2014, 15:21
Báo cáo y học: "Improving the prediction of yeast protein function using weighted protein-protein interactions" pps
... methods of interactions in the protein system. Initially, the router will be una- ware of neighbour routers on the link. Therefore, the linked state p rotocol will be applied to the routing system, ... ocates the neighbour proteins and predicts their assigned functions and the frequency of these functions; the functions are arranged in descend- ing order according to their...
Ngày tải lên: 13/08/2014, 16:20
Báo cáo khoa học: Evaluation of potential regulatory elements identi®ed as DNase I hypersensitive sites in the CFTR gene doc
... a proportionate increase in the intensity of the DHS fragments in the control samples. In Fig. 7A the forskolin-treated chromatin shows a relative increase in the intensity of the DHS10a (1716 ... similar intensity but the DHS in intron 18 is less evident ( Fig. 5B). In contrast, the DHS in intron 18 is more prominent than those in introns 16 and 17 (Fig. 5A)...
Ngày tải lên: 08/03/2014, 10:20
Báo cáo y học: " Monocytes are essential for inhibition of synovial T-cell glucocorticoid-mediated apoptosis in rheumatoid arthritis" docx
... aminoethylcarbazole staining (red) for active caspase-3 (hematoxylin-counterstained) before (a) and after (b) treatment and diaminobenzidine staining (brown) for TUNEL (hematoxylin-counterstained) ... by the combination of locally administrated glucocorticoids with monocyte-targeted therapies rather than T-cell apoptosis-inducing therapies. Competing interests The authors declare that th...
Ngày tải lên: 09/08/2014, 01:22
Báo cáo y học: "Expression and functional properties of antibodies to tissue inhibitors of metalloproteinases (TIMPs) in rheumatoid arthritis" docx
... such as certain inflammatory cytokines (IL-6, IL-1β) and by certain growth factors. Extracellularly, TIMPs inhibit MMP activity by forming high- affinity noncovalent complexes with MMPs. The amino-termi- nal ... amino-termi- nal domain of TIMP binds the active site of MMPs, inhibiting their proteolytic activity. The carboxy-terminal domain of cer- tain TIMPs has also the ability to...
Ngày tải lên: 09/08/2014, 06:23
Báo cáo y học: "Cost-effectiveness analysis of clinical specialist outreach as compared to referral system in Ethiopia: an economic evaluation" pot
... referral system in Ethiopia?” Methods The main factor determining the outcome of interest, access to clinical specialist services, is the availability of limited number of specialists in the country. ... ophthalmology, gynecology, pediatric surgery, neurology, radiography, gastroenterology and anesthesiology[1]. The project mobilized these volun- teers from urban centers to the...
Ngày tải lên: 13/08/2014, 11:22
Báo cáo y học: "Demonstrating the benefit of medical emergency teams (MET) proves more difficult than anticipated"
... (p=0.01) was seen from baseline to the study period for both groups combined. Conclusion The MET system greatly increases emergency team calling, but does not substantially affect the incidence ... 30% reduction in the primary endpoint. Unfortunately, the incidence rate for the primary outcome was much smaller than anticipated while inter-hospital variability and intra-cl...
Ngày tải lên: 25/10/2012, 10:39