Báo cáo y học: "Modeling Neisseria meningitidis metabolism: from genome to metabolic fluxes" potx

... the protonmotive force to drive oxida- tive phosphorylation. During oxidation of cysteine to cystine, electrons from cysteine are transferred to oxygen, yielding reactive oxygen, O 2 - , as shown ... is oxidized to cystine (CYST), forming reactive oxygen O 2 - (step 1), which can reduce cytochrome c (step 4). The electron is used by cytochrome cbb 3 , which reduces oxygen to...

Ngày tải lên: 14/08/2014, 07:22

... study proves to be an adjunct to the study presented in Figure 13 i n estab lishing the refractory nature of the RyR channel. Cytosolic Buffering In our model, cytosolic buffering is attributed to ... Ca 2+ release by RyRs were actually the local nanodomains of [Ca 2+ ] generated by ne arby L-type channels, rather than the global cytosolic [Ca 2+ ] myo . According to this hypothesis,...

Ngày tải lên: 13/08/2014, 16:20

... environ- mental stress (phenotypic plasticity) and high tolerance to environmental heterogeneity [7-10]. The life cycle of invasive species is directly analogous to the study of cancer metasta- sis ... in American men today. Approxi- mately 72% of patients who undergo radical prostatectomy had DTCs in the ir marrow prior to surgery suggesting that marrow dissemination is an early event...

Ngày tải lên: 13/08/2014, 16:20

... vivo tracked by DNA heteroduplex mobility assays. J Virology 1994, 68: 6672-6683. 7. Shirly LR, Ross SA: Risk of transmission of human immunodeficiency virus by bite of an infected toddler. J Pediatrics ... detectable salivary HIV RNA may be a useful analyte for detec tion of HIV infection for monitoring responses to ARV therapy. Conclusions Our observations revealed transmission of HIV inf...

Ngày tải lên: 10/08/2014, 05:22

... Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated ... units] OP_complex1 OP_complex2 [OP_complex3] OP_complex4 OP_complex5 PurM_DNA-directed-RNA-polyermase_ATP PurM_DNA-directed-RNA-polyermase_CTP PurM_DNA-directed-RNA-polyermase_GTP PurM_DNA-direct...

Ngày tải lên: 09/08/2014, 22:24

... step, suggesting that they may be involved in the transport reaction [41,55]. An apparent pathway by which a proton might be internalized from the cytosol to reach cavity 6 is through cavities ... egion corresponding to the ion-binding site. A conserved residue, Tyr694, is making contact w ith this c avity. The Tyr694 to Ala mutant strongly decreased ATPase activity, while the Tyr694...

Ngày tải lên: 23/03/2014, 21:20

... as the excretion rates of hydroxylysylpyridinoline (HP) (e) and lysylpyridinoline (LP) (f). The effect on body weight (b) was not statistically significant. Histology confirmed the lower-joint ... BA, Van Kooyk Y: Self- and nonself-recognition by C-type lectins on dendritic cells. Annu Rev Immunol 2004, 22:33-54. 48. ‘t Hart BA, van Kooyk Y: Yin-yang regulation of autoimmunity by DCs. Trend...

Ngày tải lên: 09/08/2014, 06:23

... and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 2008, 5:621-628. 8. Lister R, O'Malley RC, Tonti-Filippini J, Gregory BD, Berry CC, Millar AH, Ecker JR: Highly integrated ... non-uniformity in short-read rates in RNA-Seq data Genome Biology 2010, 11:R50 Li et al. Genome Biology 2010, 11:R50 http://genomebiology.com/2010/11/5/R50 Page 6 of 11 a larger portion of v...

Ngày tải lên: 09/08/2014, 20:22

... human body exhibits a variety of biological rhythms. There are patterns that correspond, among others, to the daily wake/sleep cycle, a yearly seasonal cycle and, in women, the menstrual cycle. ... interval of the day in the menstrual cycle where the minimum hazard is achieved. This method is not limited to breast cancer data, and may be applied to any biological rhythms linked to rig...

Ngày tải lên: 10/08/2014, 09:20

... and inability to include predictors in the models that could significantly enhance the applicability of the predictions to more refined subgroups or individual patients. However, the work is relevant to ... models presented have the ability to predict future levels of CRP, across diagnostic categories and patient characteristics. The authors recognize their work to be exploratory, a...

Ngày tải lên: 13/08/2014, 08:20