Báo cáo y học: " Cell signaling and cancer" pot

... auspices of the charity Cancer Research UK looked at cell- signaling pathways in relation to cancer and how they may point to new therapeutic approaches. Signaling pathways and signaling mechanisms The ... Biology 2007, 8:310 Meeting report Cell signaling and cancer Eleni Bazigou* and Charalampos Rallis † Addresses: *Lymphatic Development Laboratory and † Developmental G...

Ngày tải lên: 14/08/2014, 07:22

... interesting and diverse sympo- sium during a major microbiology conference helped disseminate systems-biology ideas amongst researchers in virology, bacteriology, mycology and parasitology. While ... display reasonably normal cell- cycle progression while depending on only a single cyclin. Furthermore, cell- cycle progression could be manipulated by titrating the levels of this cyc...

Ngày tải lên: 09/08/2014, 20:21

... Steinmeyer 4 , Jurgen Schölmerich 2 , Steffen Gay 5 and Ulf Müller-Ladner 1 Abstract Introduction: Rheumatoid arthritis synovial fibroblasts (RASF) are key players in synovial pathophysiology and ... is therefore mandatory to identify novel therapeutic targets to inhibit the progressive joint destruction by RASF. Several cytogenetic and molecular biology techniques are currently used t...

Ngày tải lên: 12/08/2014, 12:20

... (radio- and chemother- apy)): (1) Promoting tumor cell- tumor cell adhesion and thus increasing the tumor surface tension σ Interestingly, experiments on prostate cancer cells have already shown ... branching system that rapidly expands into the sur-rounding extracellular matrix gelFigure 1 Microscopy image of a multicellular tumor spheroid, exhibiting an extensive branching system t...

Ngày tải lên: 13/08/2014, 16:21

... and Vishwanath R Iyer Address: Section of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, University of Texas at Austin, ... completely abrogated after U0126 treat- ment, consistent with a critical role for the MAP kinase path- way in cell cycle reentry. Signaling pathways activated by serum and GF tre...

Ngày tải lên: 14/08/2014, 16:21

... N-(2-(4-(2,2-dimethylpropionyloxy)phenylsulfonylamino)benzoyl) aminoacetic acid N-(o-(p-pivaloyloxybenzene)sulfonylamino benzoyl)glycine (Calbiochem) IC 50 = 50 nM [39] Respiratory Research 2009, ... for more that 20 years that fragments of matrix proteins, generated by pro- tease activity, have chemotactic activity for neutrophils and monocytes and may also be pro-inflammatory [17- 19]....

Ngày tải lên: 12/08/2014, 14:20

... (University of Queens- land, Australia) and colleagues reported a novel way to map regulatory networks by surveying the transcriptional output in a model system of ES cell differentiation. They used transcript ... cap analysis gene expression (CAGE) and small RNA sequencing of mouse genome to determine the activity and transcriptional complexity of the whole genome. They subsequently...

Ngày tải lên: 14/08/2014, 08:21

... chemotherapy. On the contrary, 26% of the patients entered Phase II study with a progressive disease, following 4 chemotherapy cycles. Pregnancy or lactation, secondary malignanc ies, or history of hypersensitivity ... of Antibody Titers Blood samples were collected every 14 days for 60 days and monthly thereafter. Anti-EGF antibody titers were measured through an enzyme linked immunosorben...

Ngày tải lên: 11/08/2014, 08:21

... phosphoenolpru- vate-hydrolyzing specific activity of 222 UÆmg )1 and a recovery of approximately 3%, whereas SAP2 was purified 50-fold to a final phosphoenolpruvate-hydrolyzing activity of 370 UÆmg )1 and a yield ... staining and analyt- ical gel filtration demonstrated that SAP1 and SAP2, respectively, exist as 84 and 57 kDa glycosylated monomers. SAP1 and SAP2 are purple acid phosp...

Ngày tải lên: 23/03/2014, 21:20

... Oncology INTRODUCTION Physical activity has many and varied effects on the human body. The physiological effects of physical activity and exercise in persons with cancer have been largely unstudied. ... Biostatistics and Epidemiology Unit, Faculty of Movement and Sport Science, and Department of Medicine and Public Health, University of L’Aquila. L’Aquila, Italy 2. Supporti...

Ngày tải lên: 08/08/2014, 16:23