Báo cáo y học: "Drosophila by the dozen" docx
Báo cáo y học: "Drosophila by the dozen" docx
... that the tissue or germ layer in which they are deployed is secondary. This radical insight has implications for evolutionary biology and for Drosophila and other inverte- brates as model systems ... Cam- bridge, USA) reported that these new gene models annotated by FlyBase will be publicly available as part of release 5.2 of the FlyBase website (http://flybase.bio.indiana.edu/). The...
Ngày tải lên: 14/08/2014, 07:22
Báo cáo y học: "Enhancement of the Click Chemistry for the Inverse Diels Alder Technology by Functionalization of Amide-Based Monomers"
... components by use of the inverse Diels Alder technology. The high chemical stability and the ease of synthesis qualify these polyamide building blocks as favourites for intracellular delivery and ... Germany. The synthesis of the Reppe Anhy- dride was carried out as documented by Reppe [16]. The reaction to tetracy- clo-[5.4.2 1,7 .O 2,6 .O 8,11 ]3,5-dioxo-4-aza-9,12-tridec...
Ngày tải lên: 25/10/2012, 11:00
Báo cáo y học: "Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistyr"
... Synthesis of the PNA building block backbone In the next step, the synthesis of the PNA back- bone monomer using the fluorenylmethoxycarbonyl (Fmoc) protection occurred as described by Atherton ... constantly. In the process the reaction solutions colour changes to yellowish. The reaction batch was stirred continuously over night and concentrated by the rotary evapo...
Ngày tải lên: 26/10/2012, 08:57
Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt
... these enzymes catalyse an hydrolytic reaction with production of urea. The question arises therefore as to whether a similar or identical mechanism is involved in catalysis by these enzymes, which apparently ... metal-bound hydroxide for optimal attack on the guanidinium carbon of agmatine. Thus, the disruption of this hydrogen bond is the likely cause of the greately decreased ca...
Ngày tải lên: 21/02/2014, 01:21
Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
... Such a hypo- thesis is further confirmed by the observation that, differ- ently from the effect of serum, the stimulatory effect of PMA on ERK1/2 activity could also be totally abolished by NAMI-A. ... of ERK by GPCRs closely parallels that employed by RTK [33]. On the whole, these observations suggest that the inhibitory effect elicited by NAMI-A on ERK signaling might hav...
Ngày tải lên: 21/02/2014, 01:21
Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx
... examined the effects of TS on the amounts of PKCa and PKCb by Western blotting. As shown in Fig. 5B, PKCa was increased slightly by treatment with LPS/IFN. Addition of 10 l M TS to the LPS/IFN-system enhanced ... The amounts of other proteins related with the LPS-stimulated signal pathway, such as TRAF6 and MyD88 were not affected by the addition of TS in this study (data no...
Ngày tải lên: 22/02/2014, 04:20
Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules pptx
... (1997) Inhibition of the ribo- nuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthalde- hyde hydrazone. Biochemistry 36, 3179–3185. 57. ... features of the HIV-1 oligomeric enzymes PR, RT and IN and the strategies that have been developed to inhibit enzyme function by modulation of the interfaces between the subun...
Ngày tải lên: 08/03/2014, 09:20
Báo cáo Y học: Characterization of the exopolysaccharide produced by Streptococcus thermophilus 8S containing an open chain nononic acid doc
... mixtures of methyl glycosides were analyzed on GLC [14,15]. The absolute configurations of the monosac- charides were determined by GLC analysis of the trimeth- ylsilylated (–)-2-butyl glycosides [16,17]. ... influencing their physical properties [27], the presence of Sug in the backbone of the EPS produced by S. thermophilus 8S will most likely have consequences for the physi...
Ngày tải lên: 08/03/2014, 09:20
Báo cáo Y học: Inhibition of the SERCA Ca21 pumps by curcumin Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP pot
... affinity on the cytoplasmic side of the membrane. While in the E2 form the Ca 2þ binding sites have translocated across the membrane to the luminal side and are of low affinity. Furthermore, in the ... that the V max values for both the catalytic and regulatory sites are reduced by curcumin, while at higher concentrations of curcumin (25 m M) the K m for the catalytic si...
Ngày tải lên: 08/03/2014, 23:20
Báo cáo Y học: Determinants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analogues pdf
... assays Inhibitor analogues were synthesized using 4-(2¢,4¢-dimeth- oxyphenyl-Fmoc-amino methyl)phenoxyl-resins and Fmoc- amino acid derivatives by an automatic peptide synthesizer (Applied Biosystems, ... 3051 snuggly held at the S )3 site of TM-3 by hydrophobic interactions. Results from the comparisons of the synthetic inhibitor analogues show that the P )1 Trp residue of the...
Ngày tải lên: 08/03/2014, 23:20