... melatonin in theroutine care of critically ill patients, our findings need to beconfirmed by a larger, possibly multicentre, randomised con-trolled trial, ideally using polysomnography as a continuousmeasure ... written informed consent.Patients were randomly assigned to melatonin or placebo by the pharmacy, using random assignment in blocks of four.Melatonin 10 mg, formulated in an oral liquid, or matching ... wereused with the main aim of evaluating agreement and compar-ing feasibility and reliability in the critical care setting. Theseincluded actigraphy (Actiwatch; Cambridge NeurotechnologyLtd., Cambridge,...