Báo cáo y học: "Modular architecture of protein structures and allosteric communications: potential implications for signaling proteins and regulatory linkages" pot

... 5, Article R92 Research Modular architecture of protein structures and allosteric communications: potential implications for signaling proteins and regulatory linkages Antonio del Sol * , Marcos ... two androstenedion- binding sites (Figure 5a). Modular flexibility for each protein of the dataset of proteins with conformersFigure 3 Modular flexibility fo...

Ngày tải lên: 14/08/2014, 07:21

... of PTP-1B protein into Xenopus oo cytes decreases t yrosine phosphorylation of proteins correspond- ing to the molecular m ass of the IR. Correspondingly, insulin-induced S6 kinase activity and ... primarily through d ephosphorylation of IRS-2 (or other IRS proteins) , although IR and IRS-1 may be affected in other tissues or physiological states. Finally, MCK- Fig. 2. The pr...

Ngày tải lên: 17/03/2014, 23:20

... extracellular proteins, [0.21, 0.24] for nuclear proteins, [0.22, 0.26] for cytoplasmic proteins, and [0.26, 0.29] for membrane proteins. Secreted protein Non-secreted proteins Signal peptides Outside of signal ... as the ratio of the number of non-syn- onymous SNPs per non-synonymous site to the number of synonymous SNPs per synonymous site. The numbers of syn- on...

Ngày tải lên: 14/08/2014, 08:21

... Bacteriophage proteins Part of GI plu2873-plu3038 H Deletion plu3238-plu3252 22 Unknown proteins, VgrG proteins Part of GI plu3207-plu3275 I Deletion plu3380-plu3504 89 Bacteriophage proteins Part of GI ... secondary forms. We identify substantial plasticity of the genome architecture of some variants, mediated mainly by deletions in the 'flexible' gene pool of...

Ngày tải lên: 14/08/2014, 20:22

... flhC and flhD, and GatR encoded by gatR_1 and gatR_2) were represented as only one node, given that there is no evidence indicating that any of the sub- units have regulatory activity per se. Software For ... Phys Rev E Stat Nonlin Soft Matter Phys 2003, 67:026112. 20. Thomas R: Laws for the dynamics of regulatory networks. Int J Dev Biol 1998, 42:479-485. 21. Thieffry D, Ro...

Ngày tải lên: 14/08/2014, 21:20

... anorexia nervosa: a potential biomarker for the severity of disease? Annals of General Psychiatry 2011 10:16. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient ... C3 levels, the extent of complement activation and of complem ent hemolytic activity in serum, as potential new biom arkers for the severity of anorexia nervosa. Patients...

Ngày tải lên: 09/08/2014, 01:21

... NBI-31772 [1-(3,4- dihydroxybenzoyl)-3-hydroxycarbonyl-6,7-dihydroxyisoqui- noline; C 17 H 11 NO 7 , 342.06 Da] [32] was synthesized by Professor J -Y Laronze (University of Reims, Reims, France). During ... analog of IGF-1 with a greatly reduced affinity for IGF-binding proteins) on total proteoglycan synthesis by human osteoarthritis chondrocytesEffect of insulin-like growth facto...

Ngày tải lên: 09/08/2014, 01:23

... the study, participated in its design and per- formed all the experiments. KU, YT and HY performed the ani- mal study. TH performed the macroscopic and histological assessments. YT performed the ... rheumatology and related research in arthritis, and arthroscopic use of this method may potentially be preferable for in vivo assessment. However, the present machine is too big for...

Ngày tải lên: 09/08/2014, 10:21

... use of these ligands. MP quantification by flow cytometry Flow cytometry experiments were adapted from Combes and colleagues [14] and Robert and colleagues [15]. All analyses were performed by ... consumed by sPLA2. This enzyme is increased in level and activity in some inflammatory diseases and catalyzes hydrolysis of aminophos- pholipids, including PS, as well as phosphatidylc...

Ngày tải lên: 09/08/2014, 14:22

... genes and Cox17, potential targets in both yeast and human. (c) Examples of drugs with similar homozygous fitness profiles; the similarity is due to shared sensitivity of strains deleted for multi-drug ... struc- tural similarity (295 and 37 pairs in the heterozygous and homozygous datasets, respectively). Of these pairs, 74% and 90% in the heterozygous and homozygous da...

Ngày tải lên: 09/08/2014, 20:21