Báo cáo y học: " Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis" ppt

... signatures by using regulatory motif analysis (Figure 1). To achieve this goal, we began by extracting all signaling pathways in the TRANSPATH database [15], and characterized each pathway by ... signaling pathway deregulation by using gene expression signatures and regulatory motif analysis Yingchun Liu * and Markus Ringnér † Addresses: * Computa...

Ngày tải lên: 14/08/2014, 07:21

... Ras-independ- ent pathways [19]. However, DNA replication genes are highly enriched by a small group of genes that were found to be regulated only by a Ras-independent pathway and were not affected by activation ... was supported by the Helen and Martin Kimmel Award for Innovative investigation and by grants from the Tauber fund, from the Min- istry of Science and Technolo...

Ngày tải lên: 14/08/2014, 08:20

... measured by both morphological analysis and flow cytometry. Morphological analysis of the nuclei was performed by staining the cells with Hoechst 33258 (Sigma), 5 lgÆmL )1 , in 30% glycerol ⁄ ... using a highly specific antibody against SphK1, untreated and prosa- posin-stimulated cells were immunoprecipitated with an antibody against SphK1 and analysed by western blot with an ant...

Ngày tải lên: 24/03/2014, 00:21

... part by chemokines and the local expression of their receptors. Chemokines and the expression of chemokine receptors by the inflamed tissue as well as by lymphocytes are there- fore likely to ... the salivary and/ or lacrimal glands, and systemic manifesta- tions. The characteristic hallmarks of pSS are focal lymphocytic infiltrates and subsequent destruction of the lacrima...

Ngày tải lên: 09/08/2014, 01:21

... is clearly an inhibitory receptor, there is controversy over whether its ligands PD-L1 and PD-L2 are costimulatory or inhibitory. Differential regulation of PD-L1 and L2 by Th1 and Th2 cytokines ... 10-producing regulatory CD4 + T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med 2002, 195:603-616. 46. M...

Ngày tải lên: 09/08/2014, 01:24

... microarray chips for each library, has a limited dynamic range and is restricted by the varying effectiveness of individual probes. Next Generation Sequencing (NGS) technologies have recently emerged ... hairpins were depleted by 75%, ~1000 depleted by 50% and ~1000 depleted by 25%. Additional file 2. Detection of hairpin depletion at reduced read counts. Reads were sampled...

Ngày tải lên: 09/08/2014, 23:20

... efficiently trns- duced by optimized retroviral hybrid vectors. Gene Therapy 2002, 9:477-487. 46. An DS, Koyanagi Y, Zhao J, Akkina R, Bristol G, Yamamoto N, Zack JA, Chen ISY: High-efficiency transduction ... purposes) AIDS Research and Therapy Open Access Research HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector...

Ngày tải lên: 10/08/2014, 05:20

Ngày tải lên: 10/08/2014, 09:22

... of stability for HF-RR amplitude and cardiorespiratory phase difference over time, and was secondarily con- firmed by a quantitative estimation. Stability could be estimated by standard-deviation ... autonomic nervous system function. Moreover, complexity of RR variability is controlled by the auto- nomic nervous system [16], and many pathological states are characterized by los...

Ngày tải lên: 12/08/2014, 11:21

... months post- operatively. Post-mortem, right knee joints were analyzed radiologically by X-ray and magnetic resonance, and histologically by the OARSI histopathology assessment system. Results: Single ... accompanied by sub- chondral bone remodeling, osteophyte formation, and synovial membrane inflammation [1]. Clinically, this dis- ease progresses slowly and principally affects...

Ngày tải lên: 12/08/2014, 15:23