Báo cáo y học: " Revealing signaling pathway deregulation by

Báo cáo y học: " Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis" ppt

... signatures by using regulatory motif analysis (Figure 1). To achieve this goal, we began by extracting all signaling pathways in the TRANSPATH database [15], and characterized each pathway by ... signaling pathway deregulation by using gene expression signatures and regulatory motif analysis Yingchun Liu * and Markus Ringnér † Addresses: * Computa...

Ngày tải lên : 14/08/2014, 07:21

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Báo cáo y học: "Spore germination in Saccharomyces cerevisiae: global gene expression patterns and cell cycle landmarks" potx

... Ras-independent pathways [19]. However, DNA replication genes are highly enriched by a small group of genes that were found to be regulated only by a Ras-independent pathway and were not affected by activation ... was supported by the Helen and Martin Kimmel Award for Innovative investigation and by grants from the Tauber fund, from the Min- istry of Science and Technolo...

Ngày tải lên : 14/08/2014, 08:20

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Báo cáo Y học: Neurotrophic signalling pathway triggered by prosaposin in PC12 cells occurs through lipid rafts doc

... measured by both morphological analysis and ﬂow cytometry. Morphological analysis of the nuclei was performed by staining the cells with Hoechst 33258 (Sigma), 5 lgÆmL )1 , in 30% glycerol ⁄ ... using a highly speciﬁc antibody against SphK1, untreated and prosaposin-stimulated cells were immunoprecipitated with an antibody against SphK1 and analysed by western blot with an ant...

Ngày tải lên : 24/03/2014, 00:21

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Báo cáo y học: "Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren’s syndrome" pdf

... part by chemokines and the local expression of their receptors. Chemokines and the expression of chemokine receptors by the inflamed tissue as well as by lymphocytes are there- fore likely to ... the salivary and/ or lacrimal glands, and systemic manifesta- tions. The characteristic hallmarks of pSS are focal lymphocytic infiltrates and subsequent destruction of the lacrima...

Ngày tải lên : 09/08/2014, 01:21

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Báo cáo y học: "Emerging mechanisms of immune regulation: the extended B7 family and regulatory T cell" pdf

... is clearly an inhibitory receptor, there is controversy over whether its ligands PD-L1 and PD-L2 are costimulatory or inhibitory. Differential regulation of PD-L1 and L2 by Th1 and Th2 cytokines ... 10-producing regulatory CD4 + T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med 2002, 195:603-616. 46. M...

Ngày tải lên : 09/08/2014, 01:24

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Báo cáo y học: "High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing" ppsx

... microarray chips for each library, has a limited dynamic range and is restricted by the varying effectiveness of individual probes. Next Generation Sequencing (NGS) technologies have recently emerged ... hairpins were depleted by 75%, ~1000 depleted by 50% and ~1000 depleted by 25%. Additional file 2. Detection of hairpin depletion at reduced read counts. Reads were sampled...

Ngày tải lên : 09/08/2014, 23:20

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Báo cáo y học: " HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector" ppt

... efficiently trns- duced by optimized retroviral hybrid vectors. Gene Therapy 2002, 9:477-487. 46. An DS, Koyanagi Y, Zhao J, Akkina R, Bristol G, Yamamoto N, Zack JA, Chen ISY: High-efficiency transduction ... purposes) AIDS Research and Therapy Open Access Research HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector...

Ngày tải lên : 10/08/2014, 05:20

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Báo cáo y học: "Editorial on participating in the Journal of Brachial Plexus and Peripheral Nerve Injur" pptx

Ngày tải lên : 10/08/2014, 09:22

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Báo cáo y học: "Positive End-Expiratory Pressure may alter breathing cardiovascular variability and baroreflex gain in " ppt

... of stability for HF-RR amplitude and cardiorespiratory phase difference over time, and was secondarily con- firmed by a quantitative estimation. Stability could be estimated by standard-deviation ... autonomic nervous system function. Moreover, complexity of RR variability is controlled by the autonomic nervous system [16], and many pathological states are characterized by los...

Ngày tải lên : 12/08/2014, 11:21

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Báo cáo y học: "Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis" pdf

... months post- operatively. Post-mortem, right knee joints were analyzed radiologically by X-ray and magnetic resonance, and histologically by the OARSI histopathology assessment system. Results: Single ... accompanied by sub- chondral bone remodeling, osteophyte formation, and synovial membrane inflammation [1]. Clinically, this dis- ease progresses slowly and principally affects...

Ngày tải lên : 12/08/2014, 15:23

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