Báo cáo y học: "New perspectives on an old disease: proteomics in cancer research" pdf

... MALDI-MS. Charting and quantifying changes in protein phosphorylation Cell signaling is often mediated by post-translational modifications that modify protein conformation, localiza- tion, activity and ... the intact protein analysis system (IPAS). This combines protein labeling with Cy dyes, three-dimensional protein separation based on charge, hydrophobicity and molecular mass, and prot...

Ngày tải lên: 14/08/2014, 07:21

... an evolutionarily conserved function of sirtuins in regulation of replicative aging by maintenance of intact telomeric chromatin. Systems and synthetic biology Whole-genome duplication during ... talk on yeast Sir2, which removes lysine 16 from histone H4, promoting chromatin silencing. Old cells have decreased levels of Sir2 protein and of histone H4 lysine 56 acetylation, and H...

Ngày tải lên: 09/08/2014, 20:20

... clinicians’ reasoning. I find this book most interesting in the insight that it provides into the American experience with confronting the principle of medical futility. In 1991, the American ... American Thoracic Society defined a life-sustaining intervention as futile ‘… if reasoning and experience indicate that the intervention would be highly unlikely to result in a meaningful survi...

Ngày tải lên: 12/08/2014, 19:22

... RJ, Kurtin PJ, Goronzy JJ, Weyand CM: BLyS and APRIL in rheumatoid arthritis. J Clin Invest 2005, 115:3083-3092. 14. Jonsson MV, Szodoray P, Jellestad S, Jonsson R, Skarstein K: Association between ... inhibited by the increased availability of BAFF, which by binding to the BAFF- R induces upregulation of anti-apoptotic proteins [4,34]. Another concern is the association of increased BAFF a...

Ngày tải lên: 09/08/2014, 08:23

... function by transforming growth factor beta, interleukin-4, and inter- leukin-10. Ann N Y Acad Sci 1993, 685:713-739. 20. Bogdan C, Vodovotz Y, Nathan C: Macrophage deactivation by interleukin 10. ... IL-10 prevents inflammation and mucosal damage in animal models of colitis and in human colitis. Interleukin-10 (IL-10), an endogenous anti-inflammatory and immunomodulating cytokine, h...

Ngày tải lên: 11/08/2014, 08:21

... associated with an increase in muscle mass probably mediated by inhibition of muscle proteolysis rather than by stimulation of muscle protein synthesis [27]. Inhibition of muscle proteolysis, in parti- cular ... proteolysis in cultured L6 myotubes. Shock 1998, 10:298-306. 39. Yin HN, Chai JK, Yu YM, Shen CA, Wu YQ, Yao YM, et al: Regulation of signaling pathways downstream of IGF-I/in...

Ngày tải lên: 12/08/2014, 13:22

... activities. § Investigation, verification and laboratory confirmation of suspected cases. † Other support activities include training, supervision, communication and coordination. ¶Laboratory and treatment ... [20,21]. In this study, we measured the incremental costs of setting-up and implementing an integrated sur- veillance and response strategy in Burkina Faso, Eritrea and Mali. In...

Ngày tải lên: 13/08/2014, 11:22

... erent types of lung injury, mainly pulmonary and extra-pulmonary origin; 2) diff erences in the severity of lung injury; 3) the transpulmonary pressures reached during recruitment maneuvers; ... recruitment maneuver in models of pulmonary and extrapulmonary ALI, induced by intratracheal and intraperitoneal instillation of Escherichia coli lipo poly- saccharide, with similar transpulm...

Ngày tải lên: 13/08/2014, 20:21

... and IFNIR as a consequence of the inability of macrophages to efficiently degrade cytosolic DNA [54]. Ankylosing spondylitis, TLR2 and TLR4 Ankylosing spondylitis is a multifactorial and polygenic inflammatory ... Asp299Gly and Thr399Ile polymorphisms and ankylosing spondylitis [56], but no link with the Asp896Gly polymorphism [57]. The functional consequences of these polymorphisms and the m...

Ngày tải lên: 09/08/2014, 14:21

... These findings suggest that XB130 could be a novel oncoprotein in cancer. A deeper understanding of these mechanisms Binding Partner pY pY XB130 pY pY XB130 Binding Partner inactive active tyrosine ... These findings indicate that XB130 has an important role in the regulation of tyrosine kinase-mediated signaling. Roles of XB130 in cell cycle and survival To investigate the role of X...

Ngày tải lên: 10/08/2014, 09:22