Báo cáo y học: "Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury" pdf

... Access Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury Bart P Ramakers 1,2 , ... increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and s...

Ngày tải lên: 14/08/2014, 07:21

... viral DNA synthesis does not appear to be absolutely required for nuclear import of the HIV-1 RTC. Next, we tested if imp7 KD influenced the distribution of viral DNA and RNA in acutely infected ... the nuclear fractions with cytoplasmic material and as a internal standard for the quality/quantity of cDNA synthesis. Figure 6A shows that cytoplasmic contamination of th...

Ngày tải lên: 13/08/2014, 05:21

... activity during the first infusion. The link between strong anti-TNF-α activity induced by the first infusion and the good clinical response confirms the key role played by TNF-α in approximately ... their RA was not much driven by TNF-α activity alone but probably by other cytokines or mechanisms. The heterogeneity in these patterns may be explained by higher disease ac...

Ngày tải lên: 09/08/2014, 06:22

... investigate coupling of the A 2B AR to the adenylyl cyclase pathway. This is the first report of the use of Western blot analysis to confirm the presence of A 2A and A 2B ARs in human neutrophils. ... receptors in the potentiation by adenosine of the inhibitory effect of theophylline on human eosinophil degranulation: possible novel mechanism of the ant...

Ngày tải lên: 09/08/2014, 06:22

... in chondrocytes appear to push the homeostatic balance toward ECM synthesis but at the expense of the chondrocytic phenotype. We therefore hypothesize that dur- ing the 'biosynthetic phase' ... increased the release of newly synthesized sulphated glycosaminoglycan and collagen into the media, whereas inhibition of PKR in sphingomyelinase-treated cells reduced...

Ngày tải lên: 09/08/2014, 08:22

... performed histological analyses. MJV and RAWvL participated in the designing and planning of the study. JH and PPT designed and conceived the study, helped to analyse the data, and helped to draft the manuscript. ... explained by an effect on cytokine profiles in the lymphoreticular system or the humoral response. Con- ceivably, CD97 blockade exerts its effects...

Ngày tải lên: 09/08/2014, 08:22

... Briefly, the formula X N = 2 -ΔC T was used, where X N is the relative amount of target gene in question and ΔC T is the difference between the C T of the gene in question and the C T of the housekeeping ... expression of these molecules in bone has not been established. The objective of this study was to measure, in humans, the serum levels of RANKL a...

Ngày tải lên: 09/08/2014, 10:22

... sensitivity of approximately 70% and a specificity of 97% for the diagnosis of RA [7,11,12]. The citrullinated α- and β-chains of fibrin have been identified as potential targets of the autoantibody response ... fibrinogen-containing ICs, and applied these immunoassays to plasma samples derived from RA and control patients. In the present study, we further investig...

Ngày tải lên: 09/08/2014, 10:23

... separated by the proximity of the cells to the joint space and the bone respectively, alignment of the chondrocytes along the arcades of Benninghoff [29] and by the appearance of hypertrophic cells. ... chondrogenesis of primary MSCs and to investigate whether levels and extent of hyper- trophy in vitro is influenced by the choice of transgene. Materials...

Ngày tải lên: 09/08/2014, 14:22

... is one of the major mechanisms by which a ce ll responds to its environment, and the regu- lation of transcription has been one of the most inten- sively studied processes in biology over the past ... details 1 Department of Biological Chemistry and Molecular Pharmacology, Harvard University, 240 Longwood Avenue, Boston, MA 02115, USA. 2 Department of Biochemistry and...

Ngày tải lên: 09/08/2014, 20:22