... population-based evidence that sta-ble COPD patients have a pro-inflammatory state, withincreased circulating levels of many inflammatory cytok-ines and acute-phase reactants. In addition to ... selectedpatient samples, which have shown activation of circulat-ing inflammatory cells and increased levels of proinflam-matory cytokines and acute-phase reactants as well asincreased oxidative stress ... Enfermedades Respiratorias, Spain, 4Pneumology Department, Hospital Reina Sof a, Córdoba, Spain, 5IMIM/CREAL Barcelona, Spain, 6Medical Department, GlaxoSmithkline S .A. , Madrid, Spain, 7Pneumology...