Báo cáo y học: "Anemia in the ICU: are your patients needin’ erythropoetin" doc

... as there is a demonstrated mortality beneﬁ t, but these patients should be able to safely receive prophylactic heparin.Competing interests The authors declare that they have no competing interests.Published: ... however, are not entirely conclusive. With further analysis, the authors showed that the increase in throm botic events only aﬀ ected patients not receiving heparin prophylaxis.  e incidence ... Care Medicine 1999, 27: 2346-23502. Corwin HL, Gettinger A, Pearl GR, Fink MP, Levy MM, Shapiro MJ, Corwin MJ, Colton TC: E cacy of Recombinant Human Erythropoietin in Critically Ill Patients: ...

Báo cáo y học: "Agitation in the ICU: part one Anatomical and physiologic basis for the agitated state" ppt

... when injectedintravenously, probably interacting with noradrenergicneurons in these areas, increasing activity [63]. CRF mayReview Agitation in the ICU: part one Crippen R39biochemistry, neurophysiology, ... Pain signals may be editedat the spinal cord level, in the periaqueductal gray matterand brain stem raphe nuclei prior to reaching relays andgating mechanisms in the thalamus on the way to the ... pain from peripheral nocieceptors are inte-grated and relayed via integrated afferent pathways from the hypothalamus to the reticular activating system via the reticular formation, beginning in...

Báo cáo y học: "Incretins in the ICU: is insulin on its way out" pdf

... gastric emptying in the critically ill patient. If safe to do so, based on physiology,GLP-1 may have even greater effects on hyperglycemia if patients are fed enterally in the stomach rather than ... used in patients receivinggastric nutrient feeding as it decelerates gastric emptying,potentially increasing the risk of aspiration, especially given the already high incidence of delayed gastric ... effects on insulinand glucagon in hospitalized patients. Finally, GLP-1 in and ofitself may not cause hypoglycemia. When used in conjunctionwith insulin, however, effects on hypoglycemia will...

Báo cáo y học: "Weakness in the ICU: a call to action" potx

... polyneuro-pathy were less common in patients receiving tight glycemiccontrol [7]. Another key development has been a growingappreciation of the benefits of early mobility in critically ill patients. ... electro-physiological studies document evidence of polyneuropathyand/or myopathy that can endure months to years after the acute illness [5]. Although the burden of these outcomes isincreasingly appreciated, ... Hospitalier de Poissy-Saint-Germain, Poissy 78300, France4Department of Intensive Care Medicine, AP-HP, Hôpital Raymond Poincaré, Université Versailles Saint-Quentin en Yvelines, Garches 92380,...

Báo cáo y học: "Developments in the scientific and clinical understanding of gout" docx

... the inflammatory effects of MSU [24],suggesting that the pro-inflammatory effects of IL-1 requiremesenchymal cells such as the endothelium to respond tothis cytokine. Together, these findings ... of therapy(when compared with allopurinol) and highlights the importance of prescribing an effective prophylactic therapy toprevent gout flares at the initiation of any hypouricemictherapy. ... is the normal product of purine metabolism in humans and in the plasma exists mainly in the form of urate. In the moreacidic environment of the renal tubule, however, it is foundmainly in the...

Tài liệu Báo cáo Y học: Mutations in the docking site for cytochrome c on the Paracoccus heme aa3 oxidase Electron entry and kinetic phases of the reaction pptx

... not maintained by the neighbouring tyrosine,while the W121F /Y1 22F mutant activity may be viewed asa commitment of the tyrosine residue to support the (somewhat higher) residual activity of the ... notaddress the question whether any other (aromatic) sidechains in this or the neighbouring position might be able tosupport electron transfer to the CuAsite, thereby function-ally replacing tryptophan ... Thus, the observed low ionic strength nonhy-perbolic Michaelis–Menten kinetics may not be solely dueto changes in the initial ferrocytochrome c concentration,and rather are an intrinsic enzymic...

$Báo cáo Y học: Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions pot$

Báo cáo Y học: Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions pot

... possessing asimilar apparent binding afﬁnity (Kd) for the large lipidparticles, are notably distinct in their maximum bindingcapacities (Table 2). In particular, the binding footprintfor the ... obtained byanalytical ultracentrifugation using the direct binding assay as des-cribed in Experimental procedures. Inset: Linearized plot of the binding data for apoE(263–286) (symbols) shown in ... raises the possibility that any one or acombination of these properties may in uence the bindingof apolipoproteins to lipoprotein particles. The capacity tofractionate lipid emulsions into relatively...

Báo cáo y học: Advances in the Surgical Management of Chronic Rhinosinusitis" pot

... state of the art in endoscopic sinussurgery includes many recent innovations. Prob-ably the most fundamental change in sinus surgeryhas been the adaptation of rigid endoscopes for use in the nose. ... new technology has been,theoretically, to increase the safety and com-pleteness of surgery in addition to increasing the confidence of the surgeon. This accounts for the increasing numbers of ... outcomesis gradually gaining acceptance in the literature and in the staging systems used for CRS. In longitu-dinal studies of patients who have undergonefunctional endoscopic sinus surgery, with a...

Báo cáo y học: "Alterations in the complement cascade in post-traumatic stress disorder" potx

... modulating the immune function [42,43]might affect the initial steps in the inflammatory cascadeand thus influence alterations in the functional activityof the major mediator of the inflammatory ... protein C3 is the initial point of the alternativepathway,and,atthesametime,aconvergepointofallthree complement activation pathways, i.e. starting pointfor the terminal pathway [16-18].Hypoactivation ... levels of the anti-inflammatory cytokine IL-4 [12].This study was focused on the functional state of the major mediator of the inflammation, the complementsystem, in PTSD. The results obtained clearly...

Báo cáo y học: "Developments in the clinical understanding of osteoarthritis" docx

... that pain fibers can be identified in the synovium, in ligaments especially near their insertions, in bone, in muscle, and in the outer third of the meniscus in the knee. In an unusual study in which ... centralsensitization in patients with hip OA. Intriguingly, after these patients underwent hip replacement surgery, they wereretested and their noxious inhibitory control had returned tonormal. These findings ... When the joint is young andhealthy, complex and overlapping systems protect it frominjury. These include the muscles across the joint whichcontract in a smooth coordinated fashion through the excursion...

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