Báo cáo y học: "Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock" ppt

... al.: Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock. Critical Care 2010 14:R217. Submit your next manuscript ... Access Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic...

Ngày tải lên: 14/08/2014, 07:21

... characterize ovine endotoxin-induced lung injury, a frequently used model of acute lung injury. Recombinant human activated protein C (rhAPC), with its anticoagulant, anti-inflammatory, fibrinolytic ... sheepProtein kinase C α and ε isoforms in the cytosole fraction of lungs from sheep. Western blots and densitometry tracings of protein kinase C (PKC)α and PKCε...

Ngày tải lên: 13/08/2014, 11:22

... as early immunologic effectors in hemorrhage- or endotoxemia- Key messages • In ovine oleic acid-induced lung injury, recombinant human activated protein C (rhAPC) ameliorates the increments in ... nearly 30% decrease in oxygen delivery was caused mainly by a combined decline in SaO 2 and CI with OA alone and almost solely by a decrease in CI in the OA+rhAPC grou...

Ngày tải lên: 13/08/2014, 11:23

... nonseptic origin. Low levels of protein C in acute lung injury are associated with poor clinical outcome. The present article discusses the beneficial effects of rhAPC in oleic acid-induced lung injury ... recombinant human activated protein C (rhAPC) has been reported to increase survival from severe sepsis. Protein C levels also decrease markedly in acute...

Ngày tải lên: 13/08/2014, 11:23

... 4 days, respectively (Fig. 3). Figure 2 Levels of protein C and protein C inhibitorLevels of protein C and protein C inhibitor. Plasma levels of (a) protein C and (b) protein C inhibitor in the ... activation [2]. Thrombin may also affect the production of inflammatory cytokines by binding to protease -activated receptors (PARs) in mononuclear cells [3]. Sec...

Ngày tải lên: 12/08/2014, 22:22

... Griffin JH: Direct detection of activated protein C in blood from human subjects. Blood 1992, 79:2340-2348. 15. Yan SB, Dhainaut JF: Activated protein C versus protein C in severe sepsis. Crit Care ... Griffin JH: Anticoagulant synergism of heparin and activated protein C in vitro. Role of a novel anticoagulant mechanism of heparin, enhancement of inactivation...

Ngày tải lên: 14/08/2014, 07:21

... of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy. 2 IRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, Italy. Authors’ contributions CC carried ... participates in the acute inflammatory response, mice were injected in the pleural cavity with carrageenan to obtain an acute lung inflam- mation, usually defined as carrageenan-i...

Ngày tải lên: 12/08/2014, 11:20

... baseline for future studies of clinically significant Glc6P dehydrogenase mutants. Furthermore, our recently solved crystallographic structure of human Glc6P dehydrogenase [16,17] clearly vindicates ... BamHI/SalI-cleaved pTrc99A. The recombinant plasmid, designated pTrc/ G6PD, was shown by dideoxy sequencing to contain the complete human Glc6P dehydrogenase coding sequence. Expression an...

Ngày tải lên: 08/03/2014, 22:20

... data types and protein- protein interologs from yeast, worm and fly since they all rely on the same phylogenetic trees. Many human protein interactions in interaction databases we used (IntAct, ... constructed a protein functional interaction network by extending curated pathways with non- curated sources of information, including protein- protein interactions, gene coexpression...

Ngày tải lên: 09/08/2014, 20:22

... intravenous infusion. Secondary objectives included assessment of the preliminary biologic activity/phar- macodynamics of ACZ885 using ACR criteria for clinical response and Disease Activity Score using ... randomization. This multicentre study was conducted in accordance with GCP (Good Clinical Practice) guidelines and the Helsinki Declaration in three countries in Europe. The stud...

Ngày tải lên: 09/08/2014, 10:23