Medical Management of Diabetes and Heart Disease - part 10 potx

... Editors BURTON E. SOBEL is Amidon Professor and Chair of the Department of Medicine and Professor of Biochemistry at the University of Vermont College of Medicine and Physician-in-Chief, Fletcher Allen Health ... providers and patients as partners in managing a devastating disease. The demands for daily self -management of diabetes are so formidable that each component...

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... York, NY 100 16 tel: 21 2-6 9 6-9 000; fax: 21 2-6 8 5-4 540 Eastern Hemisphere Distribution Marcel Dekker AG Hutgasse 4, Postfach 812, CH-4001 Basel, Switzerland tel: 4 1-6 1-2 6 1-8 482; fax: 4 1-6 1-2 6 1-8 896 World ... consequence of their hyperglycemia and its treat- ment and not as an intrinsic part of the disease itself. The development of cardio- va...

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... Report of the expert committee on the diagnosis and classification of diabetes melli- tus. Diabetes Care 2001; 24(suppl 1):S5–S20. 2. Wingard DL, Barrett-Cannor E. Heart disease and diabetes. In: Diabetes ... secretion and insulin action in non-insulin-dependent diabetes mel- litus are inherited: Metabolic studies on offspring of diabetic probands. J Clin Invest 1998;...

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... Americans, and Hispanic Americans have a two- to sixfold greater preva- lence of diabetes when compared with white non-Hispanic Americans (3,4). Type 1 diabetes comprises 5 to 10% of diagnosed ... inhibitor and binds to and inhibits t-PA and u-PA (uroki- nase plasminogen activator). Sources of PAI-1 include hepatocytes, endothelial cells, adipocytes, and smooth muscle cel...

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... evolution and persistence of thrombosis and the rapidity and extent of lysis of thrombi associated with vascular damage and its repair, overexpression of PAI-1 is likely to exacerbate both devel- opment ... concentra- tion of PAI-1 in blood in normal subjects. Both phenomena, hormonal (hyperin- sulinemia) and metabolic (hyperglycemia and hypertriglyceridemia) derange- me...

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... (IRS-1 and IRS-2), and activation of the phosphoinositol 3′ kinase (PI-3′-K) pathway. On the other hand, cell growth and differentiation are regu- lated primarily by the SHC, GRB-2, and the MAP-kinase ... insulin resistant, and perhaps as many as 25% of overweight/obese individuals are nor- 8 Detection and Diagnosis of Syndromes of Insulin Resistance and of Diabetes...

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... resting heart rate of 100 beats per minute or more after 15 min of rest in a supine position (in the absence of other causes). 2. Beat-to-Beat Variability: Defined as a lack of beat-to-beat variability of ... evolution of macrovascu- lar disease, although this prophylactic strategy is utilized by many physicians in the management of patients with type 2 diabetes. In a rece...

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... lev- els of high-density-lipoprotein (HDL) cholesterol, and increased low-density-li- poprotein (LDL) cholesterol, hypertension, and central obesity with an increased waist-to-hip ratio. Many cross-sectional ... regarding ag- gressive medical therapy in the context of state -of- the-art coronary revasculariza- tion. In summary, stenting is feasible in diabetics with favorable proced...

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... PTCA- and CABG-treated patients even in subgroups of diabetes and three-vessel disease (31). In addition to the randomized trials com- paring PCI and CABG, three large, single-center registries and ... survival rate of insulin-treated diabetic patients with two-vessel disease was similar at 5 and 10 years for PTCA and CABG (22). In BARI, however, 7-year survival of d...

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