Medical Management of Diabetes and Heart Disease - part 5 pot

... (IRS-1 and IRS-2), and activation of the phosphoinositol 3′ kinase (PI-3′-K) pathway. On the other hand, cell growth and differentiation are regu- lated primarily by the SHC, GRB-2, and the MAP-kinase ... insulin resistant, and perhaps as many as 25% of overweight/obese individuals are nor- 8 Detection and Diagnosis of Syndromes of Insulin Resistance and of Diabetes...

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... Professor of Biochemistry at the University of Vermont College of Medicine and Physician-in-Chief, Fletcher Allen Health Care, Burlington, Ver- mont. The editor of Medical Management of Heart Disease ... factors, 157 CHD, 130 dyslipidemia, 154 – 155 hypertension, 152 – 153 , 157 impaired glucose tolerance, type 2 dia- betes, 150 – 152 inhibin, 153 – 154 insulin resist...

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... 10016 tel: 21 2-6 9 6-9 000; fax: 21 2-6 8 5- 4 54 0 Eastern Hemisphere Distribution Marcel Dekker AG Hutgasse 4, Postfach 812, CH-4001 Basel, Switzerland tel: 4 1-6 1-2 6 1-8 482; fax: 4 1-6 1-2 6 1-8 896 World Wide ... Hodis, and Wendy J. Mack 12. Management of Patients with Diabetes and Coronary Artery Disease 1 85 William E. Boden 13. Pathophysiology and...

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... Report of the expert committee on the diagnosis and classification of diabetes melli- tus. Diabetes Care 2001; 24(suppl 1):S5–S20. 2. Wingard DL, Barrett-Cannor E. Heart disease and diabetes. In: Diabetes ... ischemic heart disease. JAMA 1998; 279:1 955 –1961. 52 . Kannel WB. Lipids, diabetes, and coronary heart disease: Insights from the Framing- ham Study. Am He...

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... regard, PAI-1 levels have been found to be elevated in both type 1 and 2 diabetes (50 ,51 ) and in hypertension (52 ). Platelet adhesion and aggregation are increased in both diabetes and hyper- tension ... 55 :339–340. 77. Rebuffe-Scrive M, Andersson B, Olbe L, Bjorntorp P. Metabolism of adipose tissue in intraabdominal depots of nonobese men and women. Metabolism 1989; 38...

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... 55 –80 5 15 10–20 IDL 1.006–1.019 5 10 ϫ 10 6 25 35 20 50 20–40 15 25 LDL 1.019–1.063 2.3 ϫ 10 6 18– 25 5– 15 40 50 20– 25 HDL 1.063–1.21 1.7–3.6 ϫ 10 6 5 12 5 10 15 25 20–30 Density: g/dL; MW: daltons; ... poor glycemic control ↓ 10– 15% Metformin ↓ 5 15% Little or no effect Little or no effect (↑ Ͻ 5% ) TZDs a ↓ 5 25% ; possible ↑ 5 15% ; possible ↑ 10– 15% variability by...

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... sensitivity and abdominal obesity in African-American, Hispanic, and non-Hispanic white men and women. The insulin resistance and atherosclerosis study. Diabetes 1996; 45: 154 7– 155 5. 28. Laws ... resected in 1 956 to 19 65: a long-term follow-up focusing on natural history and circulating hormones. Fertil Steril 1992; 57 :50 5 51 3. 18. Edelstein SL, Knowler WC, Bain RP, Andre...

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... lev- els of high-density-lipoprotein (HDL) cholesterol, and increased low-density-li- poprotein (LDL) cholesterol, hypertension, and central obesity with an increased waist-to-hip ratio. Many cross-sectional ... as second-line therapy or as part of combination therapy. Approximately 80% of diabetic subjects will die of cardiovascular disease and more than half of those wit...

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... at 5 years in PTCA- and CABG-treated patients even in subgroups of diabetes and three-vessel disease (31). In addition to the randomized trials com- paring PCI and CABG, three large, single-center ... the treatment of diabetes and the change in focus toward aggressive management of blood glucose and lipids, one aspect of management has not changed: the patient st...

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