... tyrosinehydroxylase (TH) and tryptophan hydroxylase (TPH),both of which are involved in dopamine and serotoninbiosynthesis (Figure 4). Alcohol is known to interactwith the dopamine and serotonin ... from the information contained in the Inge-nuity Pathway Knowledge Base. Networks of thesegenes, defined as the reflection of all interactions of agiven gene defined in the literature, were then ... anintermediate, 6-pyruvoyl-tetrahydropterin (PPH4), to 1’-OXPH4, or 2’-OXPH4, and catalyzes the final step of tetrahydrobiopterin (BH4) synthesis, anessential cofactor for phenylalanine hydroxylase,...