... groupenhances the probability of function. Statistically, these ele-ments have a frequency of 0.1% in the genome (ANCOR0.1%),but the independent parameter of paralogy adds a newdimension to the functional ... Intriguingly, the manipulated animals were found tohave no detectable phenotype, despite the fact that the deleted regions had a typical distribution of low-frequencyANCORs (Figure 4), and that they ... ANCOR0.3%elements (typical length 400 bp and human-mouse identityscore > 90%). These elements were assayed for an enhanceractivity by a transgenic embryo assay, but only one wasactive. This...