Báo cáo y học: " Kinetic modeling of tricarboxylic acid cycl

Báo cáo y học: " Kinetic modeling of tricarboxylic acid cycle and glyoxylate bypass in Mycobacterium tuberculosis, and its application to assessment of drug targets" ppt

... developed kinetic models of the tricarboxylic acid cycle and glyoxylate bypass in Escherichia coli and Mycobacterium tuberculosis, and studied the effects of inhibition of various enzymes in the ... tricarboxylic acid cycle and glyoxylate bypass in Mycobacterium tuberculosis, and its application to assessment of drug targets Vive...

Ngày tải lên : 13/08/2014, 23:20

11
293
0

Báo cáo Y học: Kinetic studies of human tyrosyl-DNA phosphodiesterase, an enzyme in the topoisomerase I DNA repair pathway pot

... of cofactor for TDP enzymatic activity was examined by determining the speciﬁc activity of TDP by following the cleavage of 1 m M of substrate by 0.125 l M of enzyme in reaction buffer containing ... therapeutic utility in treating cancers that are refractory to camptothecin treatment. In order to understand the structure–activity relationship of TDP and to facilitat...

Ngày tải lên : 31/03/2014, 21:21

8
503
0

Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx

... HSPG binding at the cell surface is required for maintaining LPL stability. LPL’s C-terminal domain also appears to be involved in the binding of the enzyme to receptors such as the LDL receptor ... Strickland, D.K. (1994) The carboxyl-terminal domain of lipoprotein lipase binds to the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) and medi...

Ngày tải lên : 21/02/2014, 15:20

10
679
0

Tài liệu Báo cáo Y học: Kinetic study of sn-glycerol-1-phosphate dehydrogenase from the aerobic hyperthermophilic archaeon, Aeropyrum pernix K1 potx

... reduction by NAD + at 2.1 m M dihydroxyacetone phosphate and varying NADH concentration; B-2, in hibitio n of dihydroxyacetone phosphate reduction by NAD + at 0.32 m M NADH and varying dihydroxyacetone ... concentration; C-1, inhibition of dihydroxyac etone phosphate reduction by Gro1P at 2.1 m M dihydroxyacetone p hosphate and varying NADH concentration; C-2, Inhibition of...

Ngày tải lên : 22/02/2014, 04:20

8
448
0

Tài liệu Báo cáo Y học: Kinetic properties of bifunctional 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase from spinach leaves pdf

... mixture to inactivate the enzymes, and the Fru- 2,6-P 2 content of a 10-lL sample of the resulting mixture was determined by measuring its ability to activate PFP. For each determination of 6PF2K and ... min. The supernatant was adjusted to 3% poly(ethylene glycol) 4000 by adding 0.11 vol. of a 30% poly(ethylene g lycol) solution in buffer A . After 5 min, precipitated p...

Ngày tải lên : 22/02/2014, 04:20

11
378
0

Báo cáo Y học: Kinetic analysis of hydroxylation of saturated fatty acids by recombinant P450foxy produced by an Escherichia coli expression system docx

... substrate-accessing channel, and their guanidinium and hydroxyl groups, respectively, play crucial roles in the binding of the substrate by interacting with the carboxyl group of the substrate fatty acids ... essential for ﬁxing the carboxylate of fatty acids is maintained by replacing Arg with Lys. However, hydrophobicity at the entrance to P450foxy should be signiﬁcantly incre...

Ngày tải lên : 08/03/2014, 22:20

8
440
0

Báo cáo khoa học: " Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation" pps

... achieved in both settings. This fits clinical experi- ence; 54 Gy of radiation to the brain/posterior fossa and 36 Gy to the spine has a high probability of curing medul- loblastoma. By adjusting ... arise early in the treatment course), it is occasionally necessary to sus- pend treatment of the spine temporarily while treatment of the brain continues. Since the brain and...

Ngày tải lên : 09/08/2014, 10:21

9
332
0

Báo cáo y học: "Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites" potx

... by blocking target sites [34], or in trans, for example, by changing the secondary structure in the vicinity of the target site. In addition, a number of RNA-binding motifs have been linked to ... selecting a meaningful cutoff for repo rting target sites. The empirical distribu- tions suggest an intuitive score cutoff of -0.1 or lower, since for scores closer to zero the proba...

Ngày tải lên : 09/08/2014, 20:22

14
336
0

Báo cáo y học: " Kinetic studies of HIV-1 and HIV-2 envelope glycoprotein-mediated fusion" potx

... Specificity of binding was demonstrated by sCD4 inhibition of CD4 binding and a lack of CXCR4 binding in the absence of sCD4 (data not shown). These binding data were further corroborated by inhibition ... strains (in contrast to HIV-1) are often able to infect cells CD4-inde- pendently. Since CD4-induced binding of soluble gp120 molecules to CXCR4 was not very differen...

Ngày tải lên : 13/08/2014, 09:20

8
221
0

Báo cáo y học: "Economic modeling of the combined effects of HIV-disease, cholesterol and lipoatrophy based on ACTG 5142 trial data" pps

... Cost-effectiveness of lopinavir/ritonavir compared to atazanavir plus ritonavir in antiretroviral- experienced patients in the U.S.: Modeling the combined effects of HIV and Heart Disease. Clin Drug Invest ... included in the model. Randomized clinical trial results are the gold standard for defining safety and efficacy of therapy, but are limited t o the relatively shor...

Ngày tải lên : 13/08/2014, 11:22

10
449
0